Impaired Sphingolipid Synthesis in the Respiratory Tract Induces Airway Hyperreactivity

The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma

(2014) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Structural, mechanistic and regulatory studies of serine palmitoyltransferase

(2012) Jonathan Lowther et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

ORMDL3 modulates store-operated calcium entry and lymphocyte activation

(2012) Amado Carreras-Sureda et al.   HUMAN MOLECULAR GENETICS

Sphingosine 1-Phosphate (S1P) Lyase Deficiency Increases Sphingolipid Formation via Recycling at the Expense ofde NovoBiosynthesis in Neurons

(2012) Nadine Hagen-Euteneuer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis

(2012) Deanna L. Siow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

(2012) M. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

The genetics of asthma and allergic disease: a 21st century perspective

(2011) Carole Ober et al.   IMMUNOLOGICAL REVIEWS

Induction of Mucin and MUC5AC Expression by the Protease Activity of Aspergillus fumigatus in Airway Epithelial Cells

(2011) T. Oguma et al.   JOURNAL OF IMMUNOLOGY

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Sphingolipids regulate [Mg2+]o uptake and [Mg2+]i content in vascular smooth muscle cells: potential mechanisms and importance to membrane transport of Mg2+

(2010) Tao Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sphingosine kinase and sphingosine 1-phosphate in asthma

(2010) Wen‑Qi Lai et al.   BIOSCIENCE REPORTS

A sequence variant on 17q21 is associated with age at onset and severity of asthma

(2010) Eva Halapi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

(2010) David K. Breslow et al.   MOLECULAR CELL

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa

(2010) E. Strettoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

Systemic Administration of Sphingosine-1-Phosphate Increases Bronchial Hyperresponsiveness in the Mouse

(2009) Fiorentina Roviezzo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Activation of the lung S1P1 receptor reduces allergen-induced plasma leakage in mice

(2009) F-X Blé et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of sphingosine-1-phosphate and its receptors in asthma

(2009) J.J. Ryan et al.   DRUG NEWS & PERSPECTIVES

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

(2009) K. Mahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension

(2008) Rhian M. Touyz   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model

(2008) Teruaki Nishiuma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ORMDL3Gene Is Associated with Asthma in Three Ethnically Diverse Populations

(2008) Joshua Galanter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chromosome 17q21 Gene Variants Are Associated with Asthma and Exacerbations but Not Atopy in Early Childhood

(2008) Hans Bisgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry

(2008) Patrick M.A. Sleiman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications

(2008) Roger Tavendale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH

Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

(2008) Emmanuelle Bouzigon et al.   NEW ENGLAND JOURNAL OF MEDICINE