Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models

Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model

(2019) Angela M. Crist et al.   CIRCULATION

Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

(2018) Angela M. Crist et al.   ANGIOGENESIS

ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K ActivationHighlights

(2018) Elisenda Alsina-Sanchís et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SMAD4 Prevents Flow Induced Arterial-Venous Malformations by Inhibiting Casein Kinase 2

(2018) Roxana Ola et al.   CIRCULATION

Intravenous Bevacizumab for Refractory Hereditary Hemorrhagic Telangiectasia–Related Epistaxis and Gastrointestinal Bleeding

(2018) Vivek N. Iyer et al.   MAYO CLINIC PROCEEDINGS

FYN KYNASE IS A NOVEL MODULATOR OF ERYTHROPOIETIN SIGNALING AND STRESS ERYTHROPOIESIS

(2018) Elisabetta Beneduce et al.   AMERICAN JOURNAL OF HEMATOLOGY

Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia

(2018) Marie E. Faughnan et al.   ANGIOGENESIS

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2

(2018) Jérémy H. Thalgott et al.   CIRCULATION

Recurrence of hereditary hemorrhagic telangiectasia after liver transplantation: clinical implications and physiopathological insights

(2018) Jérôme Dumortier et al.   HEPATOLOGY

Pulmonary Arterial Hypertension and Hereditary Haemorrhagic Telangiectasia

(2018) Veronique Vorselaars et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SMAD4 Deficiency Leads to Development of Arteriovenous Malformations in Neonatal and Adult Mice

(2018) Yong Hwan Kim et al.   Journal of the American Heart Association

Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia

(2017) Lidia Ruiz-Llorente et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology

(2017) Santiago Ruiz et al.   HUMAN MOLECULAR GENETICS

Selective effects of oral antiangiogenic tyrosine kinase inhibitors on an animal model of hereditary hemorrhagic telangiectasia

(2017) Y. H. Kim et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

(2017) Yi Jin et al.   NATURE CELL BIOLOGY

Bone Morphogenetic Proteins in Vascular Homeostasis and Disease

(2017) Marie-José Goumans et al.   Cold Spring Harbor Perspectives in Biology

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

(2017) Takako Saito et al.   Cell Reports

Intra-venous bevacizumab in hereditary hemorrhagic telangiectasia (HHT): A retrospective study of 46 patients

(2017) Alexandre Guilhem et al.   PLoS One

Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies

(2016) D. M. Adams et al.   PEDIATRICS

PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

(2016) Roxana Ola et al.   Nature Communications

Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension

(2015) Edda Spiekerkoetter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Functional and splicing defect analysis of 23 ACVRL1 mutations in a cohort of patients affected by Hereditary Hemorrhagic Telangiectasia

(2015) Ferdos Alaa el Din et al.   PLoS One

Anti-angiogenic therapeutic strategies in hereditary hemorrhagic telangiectasia

(2015) Daniela S. Ardelean et al.   Frontiers in Genetics

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges

(2015) Simon Tual-Chalot et al.   Frontiers in Genetics

Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report

(2014) Eva M. Garrido-Martin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

(2014) C. Mallet et al.   HUMAN MOLECULAR GENETICS

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

(2014) Simon Tual-Chalot et al.   PLoS One

BMP9 Mutations Cause a Vascular-Anomaly Syndrome with Phenotypic Overlap with Hereditary Hemorrhagic Telangiectasia

(2013) Whitney L. Wooderchak-Donahue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

(2013) Edda Spiekerkoetter et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced Responses to Angiogenic Cues Underlie the Pathogenesis of Hereditary Hemorrhagic Telangiectasia 2

(2013) Eun-Jung Choi et al.   PLoS One

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II

(2012) Jai-Hyun Kim et al.   ANGIOGENESIS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

BMP signaling in vascular diseases

(2012) Jie Cai et al.   FEBS LETTERS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Immunosuppressor FK506 Increases Endoglin and Activin Receptor-Like Kinase 1 Expression and Modulates Transforming Growth Factor- 1 Signaling in Endothelial Cells

(2011) V. Albinana et al.   MOLECULAR PHARMACOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations

(2010) N. Ricard et al.   BLOOD

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

Hereditary hemorrhagic telangiectasia: from molecular biology to patient care

(2010) S. DUPUIS-GIROD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

(2010) Franck Lebrin et al.   NATURE MEDICINE

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia

(2009) Sung Ok Park et al.   JOURNAL OF CLINICAL INVESTIGATION

International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia

(2009) M. E. Faughnan et al.   JOURNAL OF MEDICAL GENETICS

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

(2009) K. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

Constitutively Activated ALK2 and Increased SMAD1/5 Cooperatively Induce Bone Morphogenetic Protein Signaling in Fibrodysplasia Ossificans Progressiva

(2008) Toru Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

(2007) S. O. Park et al.   BLOOD