CTRP9 knockout exaggerates lipotoxicity in cardiac myocytes and high‐fat diet‐induced cardiac hypertrophy through inhibiting the LKB1/AMPK pathway

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

(2018) Brittany A. Law et al.   FASEB JOURNAL

Manifestations and mechanisms of myocardial lipotoxicity in obesity

(2018) A. C. Sletten et al.   JOURNAL OF INTERNAL MEDICINE

Controlling the master—upstream regulation of the tumor suppressor LKB1

(2018) Lars Kullmann et al.   ONCOGENE

Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis

(2018) Dajun Zhao et al.   Cell Death & Disease

Body fatness at a young age and risks of eight types of cancer: systematic review and meta-analysis of observational studies

(2018) K. Hidayat et al.   Obesity Reviews

sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats

(2018) Yuehuai Hu et al.   ARCHIVES OF TOXICOLOGY

Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy

(2018) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress

(2018) Wei Feng et al.   FREE RADICAL BIOLOGY AND MEDICINE

High-Saturated Fat High-Sugar Diet Accelerates Left-Ventricular Dysfunction Faster than High-Saturated Fat Diet Alone via Increasing Oxidative Stress and Apoptosis in Obese-Insulin Resistant Rats

(2018) Nattayaporn Apaijai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and FailureNovelty and Significance

(2016) Mahesh Appari et al.   CIRCULATION RESEARCH

BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway

(2016) Xiao-meng Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection

(2016) Yang Yang et al.   PROGRESS IN LIPID RESEARCH

Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1

(2015) Haobo Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

C1q/TNF-Related Protein 9 (CTRP9) attenuates hepatic steatosis via the autophagy-mediated inhibition of endoplasmic reticulum stress

(2015) Tae Woo Jung et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice

(2014) Zhikui Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

(2013) Jonathan M. Peterson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy

(2013) Rui Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation

(2013) Y. Sun et al.   CIRCULATION

Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice

(2012) Hui Su et al.   BASIC RESEARCH IN CARDIOLOGY

C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway

(2011) Qijun Zheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization

(2010) David N. Brindley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION

Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin

(2008) G. William Wong et al.   FASEB JOURNAL