Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis

(2019) Zhaofei Wan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1

(2018) Mohammad-Reza Khajevand-Khazaei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroactive steroids and diabetic complications in the nervous system

(2018) S. Giatti et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Morphological and Pathological Characteristics of Brain in Diabetic Encephalopathy

(2018) Rui Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice

(2018) Hong-Ying Li et al.   REJUVENATION RESEARCH

Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

(2018) Yadong Zhai et al.   Oncotarget

Quercetin from Shallots (Allium cepa L. var. aggregatum) Is More Bioavailable Than Its Glucosides

(2018) Wieslaw Wiczkowski et al.   JOURNAL OF NUTRITION

Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats

(2018) Xia Zhu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

(2018) Amjad Khan et al.   Frontiers in Pharmacology

Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines

(2017) Jung-Yoon Choe et al.   INFLAMMATION

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

(2017) F. Sarubbo et al.   Journal of Neuroimmune Pharmacology

Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats

(2017) Xiaoxu Sun et al.   PHYSIOLOGY & BEHAVIOR

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

(2017) Vineet Mehta et al.   PHYSIOLOGY & BEHAVIOR

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1

(2017) Jing Peng et al.   Journal of Diabetes Research

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

(2017) Talita P. Domiciano et al.   Scientific Reports

Proliferative Properties of 17β-aminoestrogens in MCF-7 Human Breast Cancer Cells

(2016) Cristina Lemini et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells

(2016) Yu Wang et al.   IMMUNITY

SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells

(2016) Yanxiang Li et al.   MOLECULAR IMMUNOLOGY

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

(2016) W Jiang et al.   SPINAL CORD

The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue

(2015) Ana Elena Peredo-Escárcega et al.   Evidence-based Complementary and Alternative Medicine

Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model

(2015) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection

(2015) Luis Leyton et al.   VIRUS RESEARCH

The inflammasome and lupus

(2014) J. Michelle Kahlenberg et al.   CURRENT OPINION IN RHEUMATOLOGY

Maternal quercetin administration during gestation and lactation decrease endoplasmic reticulum stress and related inflammation in the adult offspring of obese female rats

(2014) Zhenghao Wu et al.   EUROPEAN JOURNAL OF NUTRITION

Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats

(2014) Qing-Yu Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

(2013) Wei Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats

(2013) Nagaraja Haleagrahara et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

Autoinflammation and autoimmunity: Bridging the divide

(2012) A. Doria et al.   AUTOIMMUNITY REVIEWS

Role of angiotensin II in the brain inflammatory events during experimental diabetes in rats

(2012) Renata Vargas et al.   BRAIN RESEARCH

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

(2012) S. M. Son et al.   DIABETES

Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats

(2012) Suganya Sekaran et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats

(2012) Xiupu Shi et al.   MOLECULES

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons

(2012) Tara A. LeGates et al.   NATURE

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Anti-Inflammatory Role of the Isoflavone Diadzein in Lipopolysaccharide-Stimulated Microglia: Implications for Parkinson’s Disease

(2012) Shankar J. Chinta et al.   NEUROTOXICITY RESEARCH

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Minocycline attenuates the development of diabetic neuropathic pain: Possible anti-inflammatory and anti-oxidant mechanisms

(2011) Kavita Pabreja et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vivo protective effects of quercetin against sodium fluoride-induced oxidative stress in the hepatic tissue

(2011) Seyed Mohammad Nabavi et al.   FOOD CHEMISTRY

Roles of Interleukin 17 in Angiotensin II Type 1 Receptor–Mediated Insulin Resistance

(2011) Kousei Ohshima et al.   HYPERTENSION

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation

(2010) Eri Himeno et al.   ANNALS OF NEUROLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Biochemical effects of SIRT1 activators

(2009) Joseph A. Baur   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review

(2009) Kate E. Schemmel et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

(Pre)diabetes, brain aging, and cognition

(2008) Jarbas S. Roriz-Filho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prevalence of other diabetes-associated complications and comorbidities and its impact on health care charges among patients with diabetic neuropathy

(2008) Yang Zhao et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS