COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells

A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis

(2018) Hyowon Choi et al.   MATRIX BIOLOGY

Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration

(2018) Elizabeth S. Silagi et al.   MATRIX BIOLOGY

TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells

(2017) Zariel I. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy

(2016) Rosalinda Madonna et al.   Cardiovascular Diabetology

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells

(2016) Zariel I. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-4 in intervertebral disc and cartilage: Saint or synner?

(2016) Abbie L.A. Binch et al.   MATRIX BIOLOGY

TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration

(2016) Ye Tian et al.   MATRIX BIOLOGY

Autocrine prostaglandin E2 signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway

(2015) Adeeb Shehzad et al.   BMB Reports

Reduced tonicity stimulates an inflammatory response in nucleus pulposus tissue that can be limited by a COX-2-specific inhibitor

(2015) Bart van Dijk et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Regulatory Action of Calcium Ion on Cyclic AMP-Enhanced Expression of Implantation-Related Factors in Human Endometrial Cells

(2015) Kazuya Kusama et al.   PLoS One

Tonicity-responsive enhancer binding protein haplodeficiency attenuates seizure severity and NF-κB-mediated neuroinflammation in kainic acid-induced seizures

(2014) H J Shin et al.   CELL DEATH AND DIFFERENTIATION

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

(2014) Zariel I. Johnson et al.   MATRIX BIOLOGY

Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways

(2013) Y. S. Lee et al.   FREE RADICAL RESEARCH

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: Role of Hsp70 in HIF-1α degradation

(2012) Shilpa S Gogate et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hypertonic induction of COX2 expression requires TonEBP/NFAT5 in renal epithelial cells

(2009) N.O. Favale et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of NF- B and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein

(2009) S.-H. Kim et al.   CARCINOGENESIS

Activation of TonEBP by Calcium Controls β1,3-Glucuronosyltransferase-I Expression, a Key Regulator of Glycosaminoglycan Synthesis in Cells of the Intervertebral Disc

(2009) Akihiko Hiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMP-2 and TGFβ Stimulate Expression of β1,3 Glucuronosyl Transferase-I (GlcAT-I) in Nucleus Pulposus Cells Through AP1, TonEBP and Sp1: Role of Map Kinases

(2009) Akihiko Hiyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osmolarity and Intracellular Calcium Regulate Aquaporin2 Expression Through TonEBP in Nucleus Pulposus Cells of the Intervertebral Disc

(2009) Sachin Gajghate et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A JNK1/AP-1-Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Transformation through Regulating Cell Cycle Progression

(2008) D. Zhang et al.   MOLECULAR CANCER RESEARCH