Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes

Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease

(2020) Jakub Began et al.   EMBO JOURNAL

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan

(2020) Truc Do et al.   Nature Microbiology

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

(2019) Atsushi Taguchi et al.   Nature Microbiology

Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan

(2019) Aurore Vermassen et al.   Frontiers in Microbiology

Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus

(2019) Marvin Rausch et al.   Nature Communications

Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae

(2019) Britta E. Rued et al.   mBio

SEDS–bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus

(2019) Nathalie T. Reichmann et al.   Nature Microbiology

Structural bases of peptidoglycan recognition by lysostaphin SH3b domain

(2019) Paweł Mitkowski et al.   Scientific Reports

Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases

(2019) Michael A. Welsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b

(2019) Luz S. Gonzalez-Delgado et al.   Nature Chemical Biology

Chemical tools to characterize peptidoglycan synthases

(2019) Atsushi Taguchi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

(2019) Genevieve S Dobihal et al.   eLife

False positives in using the zymogram assay for identification of peptidoglycan hydrolases

(2018) Cristian A. Escobar et al.   ANALYTICAL BIOCHEMISTRY

Imaging Bacterial Cell Wall Biosynthesis

(2018) Atanas D. Radkov et al.   Annual Review of Biochemistry

Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus

(2018) Kaitlin Schaefer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The biomass distribution on Earth

(2018) Yinon M. Bar-On et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

(2018) Alam García-Heredia et al.   eLife

A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery

(2018) Patricia D. A. Rohs et al.   PLoS Genetics

Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation

(2018) David Sychantha et al.   Frontiers in Microbiology

Identification of a Functionally Unique Family of Penicillin-Binding Proteins

(2017) Michael A. Welsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B

(2017) Yiben Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections

(2017) Veerasak Srisuknimit et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Don’t let sleeping dogmas lie: new views of peptidoglycan synthesis and its regulation

(2017) Heng Zhao et al.   MOLECULAR MICROBIOLOGY

Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

(2017) Yuan Qiao et al.   Nature Chemical Biology

In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

(2017) Kaitlin Schaefer et al.   Nature Chemical Biology

Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily

(2017) Allister Crow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FtsEX-mediated regulation of the final stages of cell division reveals morphogenetic plasticity in Caulobacter crescentus

(2017) Elizabeth L. Meier et al.   PLoS Genetics

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)

(2017) David Sychantha et al.   PLoS Pathogens

Regulation of bacterial cell wall growth

(2016) Alexander J. F. Egan et al.   FEBS Journal

SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion

(2016) Yvonne G. Y. Chan et al.   JOURNAL OF BACTERIOLOGY

Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments

(2016) Desirée C. Yang et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

SEDS proteins are a widespread family of bacterial cell wall polymerases

(2016) Alexander J. Meeske et al.   NATURE

Status of the Archaeal and Bacterial Census: an Update

(2016) Patrick D. Schloss et al.   mBio

Peptidoglycan architecture of Gram-positive bacteria by solid-state NMR

(2015) Sung Joon Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Mechanism of Action of Lysobactin

(2015) Wonsik Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of MltG as a potential terminase for peptidoglycan polymerization in bacteria

(2015) Rachel Yunck et al.   MOLECULAR MICROBIOLOGY

Regulated proteolysis of a cross-link–specific peptidoglycan hydrolase contributes to bacterial morphogenesis

(2015) Santosh Kumar Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Cell Enlargement Requires Control of Cell Wall Stiffness Mediated by Peptidoglycan Hydrolases

(2015) Richard Wheeler et al.   mBio

Enzymatic Synthesis of Lipid II and Analogues

(2014) Lin-Ya Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Substrate Specificity and Kinetic Characterization of PeptidoglycanO-Acetyltransferase B fromNeisseria gonorrhoeae

(2014) Patrick J. Moynihan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Capsular Polysaccharide ofStaphylococcus aureusIs Attached to Peptidoglycan by the LytR-CpsA-Psr (LCP) Family of Enzymes

(2014) Yvonne Gar-Yun Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction

(2014) Yuan Qiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The bacterial septal ring protein RlpA is a lytic transglycosylase that contributes to rod shape and daughter cell separation inPseudomonas aeruginosa

(2014) Matthew A. Jorgenson et al.   MOLECULAR MICROBIOLOGY

Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC

(2014) D. Mavrici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

(2014) L.-T. Sham et al.   SCIENCE

Structural basis of PcsB-mediated cell separation in Streptococcus pneumoniae

(2014) Sergio G. Bartual et al.   Nature Communications

Moenomycin Resistance Mutations in Staphylococcus aureus Reduce Peptidoglycan Chain Length and Cause Aberrant Cell Division

(2013) Yuriy Rebets et al.   ACS Chemical Biology

Wall Teichoic Acids of Gram-Positive Bacteria

(2013) Stephanie Brown et al.   Annual Review of Microbiology

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aggregates of nisin with various bactoprenol-containing cell wall precursors differ in size and membrane permeation capacity

(2013) Katharina Scherer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of rhomboid proteases in bacteria

(2013) Philip Rather   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Forming Cross-Linked Peptidoglycan from Synthetic Gram-Negative Lipid II

(2013) Matthew D. Lebar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-function analysis of the LytM domain of EnvC, an activator of cell wall remodelling at theEscherichia colidivision site

(2013) Nick T. Peters et al.   MOLECULAR MICROBIOLOGY

Peptidoglycan at its peaks: how chromatographic analyses can reveal bacterial cell wall structure and assembly

(2013) Samantha M. Desmarais et al.   MOLECULAR MICROBIOLOGY

FtsEX is required for CwlO peptidoglycan hydrolase activity during cell wall elongation inBacillus subtilis

(2013) Jeffrey Meisner et al.   MOLECULAR MICROBIOLOGY

Differentiated roles for MreB-actin isologues and autolytic enzymes inBacillus subtilismorphogenesis

(2013) Patricia Domínguez-Cuevas et al.   MOLECULAR MICROBIOLOGY

The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain

(2013) Mathieu Rocaboy et al.   MOLECULAR MICROBIOLOGY

Involvement of FtsE ATPase and FtsX Extracellular Loops 1 and 2 in FtsEX-PcsB Complex Function in Cell Division of Streptococcus pneumoniae D39

(2013) L.-T. Sham et al.   mBio

Bacterial cell-wall recycling

(2012) Jarrod W. Johnson et al.   Annals of the New York Academy of Sciences

Coordinate regulation of Gram-positive cell surface components

(2012) Brett R Hanson et al.   CURRENT OPINION IN MICROBIOLOGY

Solution Structure of IseA, an Inhibitor Protein of dl-Endopeptidases fromBacillus subtilis, Reveals a Novel Fold with a Characteristic Inhibitory Loop

(2012) Ryoichi Arai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division

(2012) Desirée C. Yang et al.   MOLECULAR MICROBIOLOGY

Bacterial growthdoesrequire peptidoglycan hydrolases

(2012) Waldemar Vollmer   MOLECULAR MICROBIOLOGY

Beyond growth: novel functions for bacterial cell wall hydrolases

(2012) Timna J. Wyckoff et al.   TRENDS IN MICROBIOLOGY

Specialized Peptidoglycan Hydrolases Sculpt the Intra-bacterial Niche of Predatory Bdellovibrio and Increase Population Fitness

(2012) Thomas R. Lerner et al.   PLoS Pathogens

More than just lysins: peptidoglycan hydrolases tailor the cell wall

(2011) Tsuyoshi Uehara et al.   CURRENT OPINION IN MICROBIOLOGY

A widespread family of bacterial cell wall assembly proteins

(2011) Yoshikazu Kawai et al.   EMBO JOURNAL

O-Acetylated peptidoglycan: Controlling the activity of bacterial autolysins and lytic enzymes of innate immune systems

(2011) Patrick J. Moynihan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synthetic Lethality of the lytE cwlO Genotype in Bacillus subtilis Is Caused by Lack of D,L-Endopeptidase Activity at the Lateral Cell Wall

(2011) M. Hashimoto et al.   JOURNAL OF BACTERIOLOGY

Characterization ofO-Acetylation ofN-Acetylglucosamine

(2011) Elvis Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LytN, a Murein Hydrolase in the Cross-wall Compartment ofStaphylococcus aureus, Is Involved in Proper Bacterial Growth and Envelope Assembly

(2011) Matthew B. Frankel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primer Preactivation of Peptidoglycan Polymerases

(2011) Tsung-Shing Andrew Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Type VI secretion delivers bacteriolytic effectors to target cells

(2011) Alistair B. Russell et al.   NATURE

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

(2011) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39

(2011) L.-T. Sham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-binding cassette transporter-like complex governs cell-wall hydrolysis at the bacterial cytokinetic ring

(2011) D. C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Daughter cell separation is controlled by cytokinetic ring-activated cell wall hydrolysis

(2010) Tsuyoshi Uehara et al.   EMBO JOURNAL

Modifications to the Peptidoglycan Backbone Help Bacteria To Establish Infection

(2010) Kimberly M. Davis et al.   INFECTION AND IMMUNITY

The Vertebrate Lysozyme Inhibitor Ivy Functions to Inhibit the Activity of Lytic Transglycosylase

(2010) Chelsea A. Clarke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus

(2010) M. L. Atilano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

LytM-Domain Factors Are Required for Daughter Cell Separation and Rapid Ampicillin-Induced Lysis in Escherichia coli

(2009) T. Uehara et al.   JOURNAL OF BACTERIOLOGY

Studying a Cell Division Amidase Using Defined Peptidoglycan Substrates

(2009) Tania J. Lupoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial cell division: assembly, maintenance and disassembly of the Z ring

(2009) David W. Adams et al.   NATURE REVIEWS MICROBIOLOGY

Quantitative high-performance liquid chromatography analysis of the pool levels of undecaprenyl phosphate and its derivatives in bacterial membranes

(2008) Hélène Barreteau et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Post-translational control of vegetative cell separation enzymes through a direct interaction with specific inhibitor IseA in Bacillus subtilis

(2008) Hiroki Yamamoto et al.   MOLECULAR MICROBIOLOGY

Bioinformatics identification of MurJ (MviN) as the peptidoglycan lipid II flippase in Escherichia coli

(2008) N. Ruiz   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular organization of Gram-negative peptidoglycan

(2008) L. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA