Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

(2019) Mengqi Li et al.   Cell Metabolism

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Pharmacology of metformin – An update

(2019) Hartmut H. Glossmann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

(2019) Benjamin D. Stein et al.   Cell Reports

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

(2018) Gemma F. Codner et al.   BMC BIOLOGY

Metformin selectively targets redox control of complex I energy transduction

(2018) Amy R. Cameron et al.   Redox Biology

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development

(2018) Nadia Boudaba et al.   EBioMedicine

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

(2018) Roger W. Hunter et al.   NATURE MEDICINE

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism

(2018) Ahmed Alshawi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase

(2016) Hannah R. Bridges et al.   BMC BIOLOGY

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination

(2016) Yu Dong et al.   MOLECULES

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation

(2015) Ali J. Chakera et al.   DIABETES CARE

Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial

(2015) Mette Marie H. Christensen et al.   DIABETOLOGIA

Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin

(2015) Naravat Poungvarin et al.   ENDOCRINOLOGY

Role of glycogen phosphorylase in liver glycogen metabolism

(2015) Loranne Agius   MOLECULAR ASPECTS OF MEDICINE

Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein

(2015) Loranne Agius   PROCEEDINGS OF THE NUTRITION SOCIETY

Quantification of Low-Level Drug Effects Using Real-Time,in vitroMeasurement of Oxygen Consumption Rate

(2015) Adam Neal et al.   TOXICOLOGICAL SCIENCES

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Parallel universes of Black Six biology

(2014) Alexander Kraev   Biology Direct

Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?

(2014) Joseph A. Baur et al.   Cell Metabolism

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

(2014) Roger W. Hunter et al.   CHEMISTRY & BIOLOGY

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes

(2012) Catherine Arden et al.   BIOCHEMICAL JOURNAL

High-carbohydrate diets induce hepatic insulin resistance to protect the liver from substrate overload

(2012) Loranne Agius   BIOCHEMICAL PHARMACOLOGY

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis

(2011) C. Arden et al.   DIABETES

Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1

(2010) Aldo Grefhorst et al.   BIOCHEMICAL JOURNAL

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice

(2009) B.-Y. Qiu et al.   DIABETES

Comparison of gene expression changes induced by biguanides in db/db mice liver

(2008) Masayuki Heishi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY