Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling

(2019) Sanjay K. Nigam et al.   Nature Reviews Nephrology

Organic anion transporters 1 and 3 influence cellular energy metabolism in renal proximal tubule cells

(2019) Jelle Vriend et al.   BIOLOGICAL CHEMISTRY

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

(2019) Jitske Jansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish (Danio rerio) Oat1 and Oat3 transporters and their interaction with physiological compounds

(2019) Jelena Dragojević et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis

(2019) Sara Brin Rosenthal et al.   Scientific Reports

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease

(2018) Sanjay K. Nigam   Annual Review of Pharmacology and Toxicology

Endogenous Metabolites-Mediated Communication Between OAT1/OAT3 and OATP1B1 May Explain the Association Between SLCO1B1 SNPs and Methotrexate Toxicity

(2018) David Martinez et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Beyond drug-drug interactions: effects of transporter inhibition on endobiotics, nutrients and toxins

(2017) Eve-Irene Lepist et al.   Expert Opinion on Drug Metabolism & Toxicology

The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut–liver–kidney axis

(2017) Kevin T. Bush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity

(2017) Xue Wang et al.   TOXICOLOGICAL SCIENCES

Analysis of drug–endogenous human metabolite similarities in terms of their maximum common substructures

(2017) Steve O’Hagan et al.   Journal of Cheminformatics

Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

(2017) Wei Wu et al.   Scientific Reports

An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network

(2016) Henry C. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters

(2015) S. K. Nigam et al.   Clinical Journal of the American Society of Nephrology

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

(2015) Sanjay K. Nigam et al.   PHYSIOLOGICAL REVIEWS

Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs

(2015) Christopher Zhu et al.   PLoS One

Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

(2015) Steve O'Hagan et al.   Frontiers in Pharmacology

The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction

(2014) Kacey J. Prentice et al.   Cell Metabolism

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

The Kidney and Uremic Toxin Removal: Glomerulus or Tubule?

(2014) Rosalinde Masereeuw et al.   SEMINARS IN NEPHROLOGY

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

Renal Transporters in Drug Development

(2012) Kari M. Morrissey et al.   Annual Review of Pharmacology and Toxicology

Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue

(2012) Megha A. Nagle et al.   NEUROSCIENCE LETTERS

Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter—Organic anion transporter1 (Oat1)

(2011) Valentina L. Kouznetsova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deletion of Multispecific Organic Anion Transporter Oat1/Slc22a6 Protects against Mercury-induced Kidney Injury

(2011) Adriana M. Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linkage of Organic Anion Transporter-1 to Metabolic Pathways through Integrated “Omics”-driven Network and Functional Analysis

(2011) Sun-Young Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Untargeted Metabolomics Identifies Enterobiome Metabolites and Putative Uremic Toxins as Substrates of Organic Anion Transporter 1 (Oat1)

(2011) William R. Wikoff et al.   JOURNAL OF PROTEOME RESEARCH

Remote Communication through Solute Carriers and ATP Binding Cassette Drug Transporter Pathways: An Update on the Remote Sensing and Signaling Hypothesis

(2011) W. Wu et al.   MOLECULAR PHARMACOLOGY

NWChem: A comprehensive and scalable open-source solution for large scale molecular simulations

(2010) M. Valiev et al.   COMPUTER PHYSICS COMMUNICATIONS

Analysis of Three-dimensional Systems for Developing and Mature Kidneys Clarifies the Role of OAT1 and OAT3 in Antiviral Handling

(2010) Megha A. Nagle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic implications of renal anionic drug transporters

(2010) Rosalinde Masereeuw et al.   PHARMACOLOGY & THERAPEUTICS

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology

(2009) Adam L. VanWert et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Interaction of Organic Cations with Organic Anion Transporters

(2009) Sun-Young Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis

(2009) S.-Y. Ahn et al.   MOLECULAR PHARMACOLOGY

Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications

(2009) Hideyuki Saito   PHARMACOLOGY & THERAPEUTICS

Update on the molecular physiology of organic anion transporters

(2008) Sun-Young Ahn et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Multi-level Analysis of Organic Anion Transporters 1, 3, and 6 Reveals Major Differences in Structural Determinants of Antiviral Discrimination

(2008) David M. Truong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organic Anion Transporter 3 Contributes to the Regulation of Blood Pressure

(2008) V. Vallon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Organic Anion Transporter 3 (Oat3/Slc22a8) Interacts with Carboxyfluoroquinolones, and Deletion Increases Systemic Exposure to Ciprofloxacin

(2008) A. L. VanWert et al.   MOLECULAR PHARMACOLOGY

Multiple organic anion transporters contribute to net renal excretion of uric acid

(2008) Satish A. Eraly et al.   PHYSIOLOGICAL GENOMICS