Recent advances in the detection of brown adipose tissue in adult humans: a review

Human Brown Adipose Tissue Temperature and Fat Fraction Are Related to Its Metabolic Activity

(2017) Kalle Koskensalo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human Brown Fat Radiodensity Indicates Underlying Tissue Composition and Systemic Metabolic Health

(2017) Mueez U Din et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MRI characterization of brown adipose tissue under thermal challenges in normal weight, overweight, and obese young men

(2017) Jie Deng et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Relation between brown adipose tissue and measures of obesity and metabolic dysfunction in patients with cardiovascular disease

(2017) Bas T. Franssens et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans

(2017) James Law et al.   JOURNAL OF NUCLEAR MEDICINE

A pilot study on the correlation between fat fraction values and glucose uptake values in supraclavicular fat by simultaneous PET/MRI

(2017) Andrew McCallister et al.   MAGNETIC RESONANCE IN MEDICINE

MR signal-fat-fraction analysis and T2* weighted imaging measure BAT reliably on humans without cold exposure

(2017) Milja Holstila et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo

(2017) Hannah Scotney et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Brown adipose tissue does not seem to mediate metabolic adaptation to overfeeding in men

(2017) Courtney M. Peterson et al.   Obesity

A virtual clinical trial comparing static versus dynamic PET imaging in measuring response to breast cancer therapy

(2017) Kristen A Wangerin et al.   PHYSICS IN MEDICINE AND BIOLOGY

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Differences between the most used equations in BAT-human studies to estimate parameters of skin temperature in young lean men

(2017) Borja Martinez-Tellez et al.   Scientific Reports

Optimizing the methodology for measuring supraclavicular skin temperature using infrared thermography; implications for measuring brown adipose tissue activity in humans

(2017) Tahniyah Haq et al.   Scientific Reports

Characterizing active and inactive brown adipose tissue in adult humans using PET-CT and MR imaging

(2016) Aliya Gifford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

(2016) Kong Y. Chen et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus

(2016) Mueez u Din et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females

(2016) Lindsay J. Robinson et al.   EXPERIMENTAL PHYSIOLOGY

In vivoassessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI

(2016) Vanessa Stahl et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Sympathetic Innervation of Cold-Activated Brown and White Fat in Lean Young Adults

(2016) Otto Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial

(2016) Qi Yan Ang et al.   Journal of Physiological Sciences

Infrared thermography for indirect assessment of activation of brown adipose tissue in lean and obese male subjects

(2016) Hamza El Hadi et al.   PHYSIOLOGICAL MEASUREMENT

Is It Possible to Detect Activated Brown Adipose Tissue in Humans Using Single-Time-Point Infrared Thermography under Thermoneutral Conditions? Impact of BMI and Subcutaneous Adipose Tissue Thickness

(2016) Sergios Gatidis et al.   PLoS One

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

A critical appraisal of brown adipose tissue metabolism in humans

(2015) Denis P Blondin et al.   Clinical Lipidology

Selective Impairment of Glucose but Not Fatty Acid or Oxidative Metabolism in Brown Adipose Tissue of Subjects With Type 2 Diabetes

(2015) Denis P. Blondin et al.   DIABETES

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

Brown adipose tissue triglyceride content is associated with decreased insulin sensitivity, independently of age and obesity

(2015) J. Raiko et al.   DIABETES OBESITY & METABOLISM

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

(2015) V. Salem et al.   DIABETES OBESITY & METABOLISM

In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis

(2015) Sébastien M. Labbé et al.   FASEB JOURNAL

A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans

(2015) M Chondronikola et al.   INTERNATIONAL JOURNAL OF OBESITY

Low brown adipose tissue activity in endurance-trained compared with lean sedentary men

(2015) M J Vosselman et al.   INTERNATIONAL JOURNAL OF OBESITY

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity

(2015) B Rachid et al.   INTERNATIONAL JOURNAL OF OBESITY

Differences in Sympathetic Nervous Stimulation of Brown Adipose Tissue Between the Young and Old, and the Lean and Obese

(2015) L. Bahler et al.   JOURNAL OF NUCLEAR MEDICINE

Discrimination Between Brown and White Adipose Tissue Using a 2-Point Dixon Water-Fat Separation Method in Simultaneous PET/MRI

(2015) D. Franz et al.   JOURNAL OF NUCLEAR MEDICINE

Supraclavicular skin temperature and BAT activity in lean healthy adults

(2015) Anouk A. J. J. van der Lans et al.   Journal of Physiological Sciences

Contrast-Enhanced Ultrasound: A Novel Noninvasive, Nonionizing Method for the Detection of Brown Adipose Tissue in Humans

(2015) Aidan Flynn et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Imaging human brown adipose tissue under room temperature conditions with 11C-MRB, a selective norepinephrine transporter PET ligand

(2015) Janice J. Hwang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Reliability and agreement of adipose tissue fat fraction measurements with water-fat MRI in patients with manifest cardiovascular disease

(2015) Bas T. Franssens et al.   NMR IN BIOMEDICINE

Human brown adipose tissue assessed by simple, noninvasive near-Infrared time-resolved spectroscopy

(2015) Shinsuke Nirengi et al.   Obesity

Hybrid PET/MRI as a tool to detect brown adipose tissue: Proof of principle

(2015) Karim Gariani et al.   Obesity Research & Clinical Practice

MRI characterization of brown adipose tissue in obese and normal-weight children

(2015) Jie Deng et al.   PEDIATRIC RADIOLOGY

Serum FGF21 levels are associated with brown adipose tissue activity in humans

(2015) Mark J.W. Hanssen et al.   Scientific Reports

Biodiversity on the Rocks: Macrofauna Inhabiting Authigenic Carbonate at Costa Rica Methane Seeps

(2015) Lisa A. Levin et al.   PLoS One

Cold-activated brown adipose tissue in human adults: methodological issues

(2014) Anouk A. J. J. van der Lans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Brown Fat in Humans: Consensus Points and Experimental Guidelines

(2014) Aaron M. Cypess et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance

(2014) Mark J. W. Hanssen et al.   DIABETOLOGIA

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

(2014) Antonio Giordano et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Brown Adipose Tissue Function is Accompanied by Cerebral Activation in Lean But Not in Obese Humans

(2014) Janne Orava et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Presence of Brown Adipose Tissue in an Adolescent With Severe Primary Hypothyroidism

(2014) Mimi S. Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

(2014) Denis P. Blondin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men

(2014) Denis P. Blondin et al.   JOURNAL OF PHYSIOLOGY-LONDON

18F-fluorodeoxyglucose uptake in brown adipose tissue during insulin-induced hypoglycemia and mild cold exposure in non-diabetic adults

(2014) Josefine E. Schopman et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Selected Core Microbiome Drives the Early Stages of Three Popular Italian Cheese Manufactures

(2014) Francesca De Filippis et al.   PLoS One

Brown adipose tissue activity after a high-calorie meal in humans

(2013) Maarten J Vosselman et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

IGFBP-2 is a negative predictor of cold-induced brown fat and bone mineral density in young non-obese women

(2013) Miriam A. Bredella et al.   BONE

Cold-induced activity of brown adipose tissue in young lean men of South-Asian and European origin

(2013) W. M. Admiraal et al.   DIABETOLOGIA

Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans

(2013) M Matsushita et al.   INTERNATIONAL JOURNAL OF OBESITY

Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography

(2013) Bart D. van Rooijen et al.   INVESTIGATIVE RADIOLOGY

Overfeeding Over 24 Hours Does Not Activate Brown Adipose Tissue in Humans

(2013) Mathias Schlögl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature

(2013) Kong Y. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of Brown Adipose Tissue Using MR Imaging in a Human Adult With Histological and Immunohistochemical Confirmation

(2013) Narendra L. Reddy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of brown and white adipose tissues in infants and children with chemical-shift-encoded water-fat MRI

(2013) Houchun H. Hu et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging

(2013) Y.-C. Iris Chen et al.   JOURNAL OF NUCLEAR MEDICINE

15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

(2013) O. Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

Combining 123I-Metaiodobenzylguanidine SPECT/CT and 18F-FDG PET/CT for the Assessment of Brown Adipose Tissue Activity in Humans During Cold Exposure

(2013) W. M. Admiraal et al.   JOURNAL OF NUCLEAR MEDICINE

Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children

(2013) Lindsay Robinson et al.   JOURNAL OF PEDIATRICS

Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice

(2013) Maëva Clerte et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

MRI detection of brown adipose tissue with low fat content in newborns with hypothermia

(2013) Houchun H. Hu et al.   MAGNETIC RESONANCE IMAGING

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

(2013) Janne Orava et al.   Obesity

Positive Outcomes Influence the Rate and Time to Publication, but Not the Impact Factor of Publications of Clinical Trial Results

(2013) Pilar Suñé et al.   PLoS One

Repeated Cocaine Exposure Facilitates the Expression of Incentive Motivation and Induces Habitual Control in Rats

(2013) Kimberly H. LeBlanc et al.   PLoS One

Brown adipose tissue volume in healthy lean south Asian adults compared with white Caucasians: a prospective, case-controlled observational study

(2013) Leontine E H Bakker et al.   Lancet Diabetes & Endocrinology

Characterization of Human Brown Adipose Tissue by Chemical-Shift Water-Fat MRI

(2012) Houchun H. Hu et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice

(2012) David M. Baron et al.   Circulation-Cardiovascular Imaging

Systemic  -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans

(2012) M. J. Vosselman et al.   DIABETES

Ephedrine activates brown adipose tissue in lean but not obese humans

(2012) A. L. Carey et al.   DIABETOLOGIA

Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans

(2012) T Yoneshiro et al.   INTERNATIONAL JOURNAL OF OBESITY

Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

(2012) G. H. E. J. Vijgen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Young Women with Cold-Activated Brown Adipose Tissue Have Higher Bone Mineral Density and Lower Pref-1 than Women without Brown Adipose Tissue: A Study in Women with Anorexia Nervosa, Women Recovered from Anorexia Nervosa, and Normal-Weight Women

(2012) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Proton density fat-fraction: A standardized mr-based biomarker of tissue fat concentration

(2012) Scott B. Reeder et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Fasting and Postprandial Activity of Brown Adipose Tissue in Healthy Men

(2012) A. Vrieze et al.   JOURNAL OF NUCLEAR MEDICINE

Thermal Imaging to Assess Age-Related Changes of Skin Temperature within the Supraclavicular Region Co-Locating with Brown Adipose Tissue in Healthy Children

(2012) Michael E. Symonds et al.   JOURNAL OF PEDIATRICS

Quantitative assessment of dynamic PET imaging data in cancer imaging

(2012) Mark Muzi et al.   MAGNETIC RESONANCE IMAGING

Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women

(2012) P. Lee et al.   OSTEOPOROSIS INTERNATIONAL

Cold but not sympathomimetics activates human brown adipose tissue in vivo

(2012) A. M. Cypess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Measuring response to therapy using FDG PET: semi-quantitative and full kinetic analysis

(2011) Patsuree Cheebsumon et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Unequivocal identification of brown adipose tissue in a human infant

(2011) Houchun H. Hu et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Age-Related Decrease in Cold-Activated Brown Adipose Tissue and Accumulation of Body Fat in Healthy Humans

(2011) Takeshi Yoneshiro et al.   Obesity

Movements of Wolves at the Northern Extreme of the Species' Range, Including during Four Months of Darkness

(2011) L. David Mech et al.   PLoS One

A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

(2010) Paul Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

(2010) C. Pfannenberg et al.   DIABETES

Hot fat in a cool man: infrared thermography and brown adipose tissue

(2010) P. Lee et al.   DIABETES OBESITY & METABOLISM

Image-derived input function in dynamic human PET/CT: methodology and validation with 11C-acetate and 18F-fluorothioheptadecanoic acid in muscle and 18F-fluorodeoxyglucose in brain

(2010) Etienne Croteau et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Determinants of brown adipocyte development and thermogenesis

(2010) D Richard et al.   INTERNATIONAL JOURNAL OF OBESITY

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of18F-FDG-Detected BAT in Humans

(2010) Veronique Ouellet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

CT Hounsfield Units of Brown Adipose Tissue Increase with Activation: Preclinical and Clinical Studies

(2010) S. Baba et al.   JOURNAL OF NUCLEAR MEDICINE

Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

(2010) Takeshi Yoneshiro et al.   Obesity

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Principles, Techniques, and Applications of T2*-based MR Imaging and Its Special Applications

(2009) Govind B. Chavhan et al.   RADIOGRAPHICS

MR thermometry

(2008) Viola Rieke et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING