Article
Biochemistry & Molecular Biology
Chen Chen, Jian-Wen Liu, Ling-Li Guo, Feng Xiong, Xiao-Qian Ran, Ya-Rong Guo, Yong-Gang Yao, Xiao-Jiang Hao, Rong-Can Luo, Yu Zhang
Summary: Three novel monoterpenoid indole alkaloid dimers (kopoffines A-C) and nine known alkaloids were isolated and identified from the fruits of Kopsia arborea Blume. Kopoffines A-C exhibited significant inhibition against cyclin-dependent kinase 5 and reduced the levels of phosphorylated Tau, which are involved in the formation of neurofibrillary tangles. These findings may have implications for the development of therapeutics for related diseases.
Article
Plant Sciences
Qiong Jin, Yun-Li Zhao, Ya-Ping Liu, Ruo-Song Zhang, Pei-Feng Zhu, Lan-Qin Zhao, Xu-Jie Qin, Xiao-Dong Luo
Summary: This study supported the traditional use of K. officinalis by evaluating the anti-inflammatory and analgesic effects of its purified MIAs. The results showed that the purified MIAs displayed significant anti-inflammatory effects in vitro and in vivo, providing potential bioactive compounds for further chemical modification and pharmacological investigation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Chen Chen, Xiao Ding, Lingling Han, Wentao Zhu, Kepu Huang, Xiaojiang Hao, Yu Zhang
Summary: Two new monoterpenoid indole alkaloids and six known alkaloids were isolated from the methanol extract of Kopsia arborea. The structures and absolute configurations of the alkaloids were determined through various analytical methods. The cytotoxicity of these alkaloids against two human cancer cell lines was evaluated.
NATURAL PRODUCT RESEARCH
(2023)
Review
Chemistry, Organic
Athira Parammal, Manoj Kumar, Shubham Singh, Joe Sam Xavier, Parthasarathi Subramanian
Summary: This review discusses the synthetic strategies and total synthesis methods of aspidofractinine and its analogues. Aspidofractinine is a natural product with fascinating structural features and biological activities, making its synthesis highly significant.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Soon-Kit Wong, Joanne Soon-Yee Yeap, Chun-Hoe Tan, Kae-Shin Sim, Siew-Huah Lim, Yun-Yee Low, Toh-Seok Kam
Summary: Three new bisindole alkaloids were isolated from the stem bark extract of Malayan Kopsia arborea, with arbolodinine B showing significant cytotoxic effects against various human cancer cell lines.
Article
Chemistry, Applied
Xue-Wei Yan, Si-Yu Du, Xiao-Tong Wang, Kong-Kai Zhu, Lei Fang
Summary: Two new monoterpenoid indole alkaloids, named taberibogines E and F (1 and 2), together with three known ones (3-5), were isolated from the stems of Tabernaemontana bovina Lour (Apocynaceae). Their structures and absolute configurations were elucidated through NMR and HRESIMS data, NMR calculations, and DP4+ probability analyses. Compounds 1 and 2 exhibited inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Organic
Guanqun Zhan, Fuxin Zhang, Kailing Yang, Tao Yang, Ruixi Zhou, Xueqing Ma, Nan Wang, Zengjun Guo
Summary: A new compound and four known compounds were isolated from Alstonia scholaris. The new compound has a unique carbon skeleton and shows potential anti-inflammatory activity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Physical
Yu-qi Li, Jing Cai, Jia-xin Cheng, Sheng-zhi Su, Toshihiro Akihisa, Wen-yuan Liu, Feng Feng, Jie Zhang
Summary: This study investigated the chemical constituents of Alstonia mairei and isolated twenty-four monoterpenoid indole alkaloids. Four new compounds were discovered. The structures of these compounds were characterized using various techniques. The cytotoxic activities of the isolated compounds were evaluated, and several compounds demonstrated potent inhibitory activities against A549 lung cancer cells.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Chemistry, Multidisciplinary
Nguyen Quang Hop, Ninh The Son
Summary: This study provides a comprehensive review of the secondary metabolites and pharmacological research of Kopsia plants. A total of 472 compounds, including 466 monoterpene alkaloids, 5 triterpenoids, and 1 sterol, were summarized. The compounds were found to exhibit various pharmacological activities such as antimicrobial and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Zhi-Wen Liu, Min Song, Jun-Ya Wang, De-Zhi Wang, Biao Sun, Lei Shi, Ren-Wang Jiang, Min Ma, Xiao-Qi Zhang
Summary: Eight unprecedented monoterpenoid indole alkaloid (MIA) adducts and dimers, melofusinines A-H (1-8), and three undescribed melodinus-type MIA monomers, melofusinines I-K (9-11), were isolated from Melodinus fusiformis. Compounds 1 and 2 are hybrid indole alkaloids incorporating an aspidospermatan-type MIA with a monoterpenoid alkaloid unit. Compounds 3-8 are the first MIA dimers constructed through an aspidospermatan-type monomer and a rearranged melodinus-type monomer.
Article
Biochemistry & Molecular Biology
Lu Liu, Ting He, Ya-Ping Liu, Jian-Xin Cao, Gui-Guang Cheng
Summary: A novel C-21/N-4 cleavage monoterpenoid indole alkaloid, 4,21-Secovincanol, along with four analogs, were isolated from the aerial parts of Kopsia hainanensis. These compounds showed significant inhibition of Con A-stimulated mice splenocytes proliferation in vitro at 10-40 μM, with compound 3 exhibiting activities comparable to the positive control Dexamethasone.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Multidisciplinary
Rui Yang, Zeyu Zhou, Huanfeng Jiang, Toh-Seok Kam, Kai Chen, Zhiqiang Ma
Summary: The first asymmetric total synthesis of the monoterpenoid indole alkaloid arboduridine has been achieved. The synthesis involves several reactions to construct the complex structure and demonstrates a highly enantioselective synthetic strategy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Jasmine Ga May Eng, Mohammadamin Shahsavarani, Daniel Patrick Smith, Josef Hajicek, Vincenzo De Luca, Yang Qu
Summary: This study discovered and characterized vindolinine synthase, an enzyme that catalyzes an unusual redox-neutral reaction, leading to alkaloid diversity. This has important implications for understanding plant specialized metabolism and alkaloid synthesis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Lan Zhou, Pian-Chou Gongpan, Qing-Fei Fan, Zhi Na, Feng-Mei Huang, Kai-Long Ji, Qi-Shi Song
Summary: Two previously unreported monoterpenoid indole alkaloids, compounds 1 and 2, along with five known compounds, were isolated from Mappianthus iodoides stems. The structures were characterized using extensive spectroscopic data, and their in vitro anti-inflammatory activities were evaluated through NO assay.
NATURAL PRODUCT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Afrah E. Mohammed, Zainab H. Abdul-Hameed, Modhi O. Alotaibi, Nahed O. Bawakid, Tariq R. Sobahi, Ahmed Abdel-Lateff, Walied M. Alarif
Summary: Interest in natural compounds as drug sources declined by the end of the twentieth century, but has recently regained importance. Indole-containing compounds, such as vinblastine and vincristine, are widely used in clinical settings for various medical conditions. Monoterpene Indole Alkaloids (MIAs) are attracting attention due to their chemical diversity and biological activities, with potential as future sources of drug leads.