Review
Allergy
Pattraporn Satitsuksanoa, Monique Daanje, Mubeccel Akdis, Scott D. Boyd, Willem van de Veen
Summary: B cells play a crucial role in the development of IgE-mediated food allergies by producing allergen-specific antibodies, but the mechanisms regulating allergen-specific IgE production and immunological memory are not fully understood. Recent technological advances have allowed detailed analysis of B cells at a single-cell level, providing a better understanding of their role in food allergies.
Article
Biochemistry & Molecular Biology
Xiaorui Geng, Jinmei Xue, Haoyue Zheng, Limin Suo, Haotao Zeng, Miao Zhao, Shuo Song, Yu Liu, Changqing Zhao, Pingchang Yang
Summary: CD46 contributes to the production of IgE and its activation may be involved in the pathogenesis of allergic diseases. This study found increased CD46 expression in peripheral B cells of patients with allergic rhinitis (AR), which was positively associated with the AR response. Ablation of CD46 in B cells prevented the production of IgE in mice with airway allergy, and exposure to aluminum hydroxide upregulated Cd46 expression. Administration of Cd46 shRNA nanoparticles attenuated experimental airway allergy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Immunology
Paul Haase, David Voehringer
Summary: The type 2 immune response is characterized by the production of IgG1 and IgE antibodies, which play a role in protective or proinflammatory functions. Recent studies have uncovered important insights into the regulatory mechanisms controlling humoral type 2 immunity, including signals from T-helper cells and intrinsic factors in B cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Mohammed Zghaebi, Maria Byazrova, Sabine Flicker, Sergio Villazala-Merino, Nicholas J. Campion, Victoria Stanek, Aldine Tu, Heimo Breiteneder, Alexander Filatov, Musa Khaitov, Verena Niederberger-Leppin, Julia Eckl-Dorna, Rudolf Valenta
Summary: A new sequential gating strategy was developed to detect cells bearing the IgE BCR on their surface, using a monoclonal anti-IgE antibody. This strategy allowed for the clear identification of allergen-specific IgE(+) memory B cells and plasma cells in human PBMCs, offering new insights into allergic responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pediatrics
Chioma Udemgba, Adora Lin
Summary: B cells play important roles in the development of food allergy and tolerance. Understanding B cell biology in the context of food allergy is crucial for effective prevention and therapy strategies. Allergen-specific IgG4 and regulatory B cells may be key components in promoting tolerance and protecting against food allergies.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Phuc-Tan Nguyen, Yuki Nakamura, Nguyen Quoc Vuong Tran, Kayoko Ishimaru, Thuy-An Nguyen, Yoshiaki Kobayashi, Fumie Watanabe-Saito, Tohru Okuda, Nobuhiro Nakano, Atsuhito Nakao
Summary: Ethyl caffeate (EC) is a natural phenolic compound found in medicinal plants and shows anti-allergic activity by inhibiting aryl hydrocarbon receptor (AhR) signaling. EC inhibits AhR activation and downregulates AhR target gene expressions. It also inhibits mast cell activation and IL-6 production induced by AhR ligands. These findings suggest a novel mechanism for the anti-inflammatory activity of EC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Paul Engeroff, Monique Vogel
Summary: IgE can bind to two receptors, playing different roles on different cells, inducing allergic reactions on one hand and participating in IgE regulation and antigen presentation on the other. In inflammation and immune homeostasis, CD23 plays an important modulatory role.
Review
Pediatrics
Shiqiu Xiong, Yang Jia, Chuanhe Liu
Summary: This review summarizes the generation of IgE(+) LLPCs, discusses the prosurvival factors in the microenvironment, and reviews the unique IgE-BCR signaling, providing insights into understanding the survival mechanisms of IgE(+) LLPCs.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Annika Wiedemann, Marie Lettau, Ina Wirries, Annemarie Jungmann, Abdulrahman Salhab, Gilles Gasparoni, Henrik E. Mei, Carsten Perka, Joern Walter, Andreas Radbruch, Andreia C. Lino, Thomas Doerner
Summary: The study revealed distinct characteristics of IgA(+) BMPC in response to BCR stimulation, showing higher sensitivity to changes in the checkpoint molecule PD-1 compared to other PC subsets regardless of CD19 expression. This indicates that IgA(+) BMPC may have different regulatory functions independent of their phenotypic heterogeneity based on CD19 expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wolfgang Pfuetzner, Alexandra Polakova, Christian Moebs
Summary: The role of B-cell memory in IgE-mediated allergies and allergen tolerance has been a mystery, but recent studies in mice and humans are shedding light on this subject. This review highlights the involvement of IgG1 memory B cells, the significance of low- or high-affinity IgE antibody production, the impact of allergen immunotherapy, and the relevance of local memory established by ectopic lymphoid structures. With these findings, future research can lead to more knowledge and improved therapies for allergic individuals.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Caijie Zhou, Meihua Li, Yu Liu, Xinxin Wang, Shuang Zhang, Li Guan, Jingyi Hong, Wei Zhou, Gaohui Wu, Weiliang Diao, Qinmiao Huang, Pingchang Yang
Summary: TAFA4 can suppress the expression of FcεRI in mast cells to attenuate experimental AR. It is negatively correlated with tryptase levels in nasal secretions and modulates the transcription of Fcer1g gene.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Review
Immunology
Mohamed Hamed Abdelaziz, Xiaoyun Ji, Jie Wan, Fatma A. Abouelnazar, Sayed F. Abdelwahab, Huaxi Xu
Summary: This article discusses the correlation between allergic asthma and natural infections, exploring effective methods for preventing allergic asthma through natural infections. The authors mentioned the impact of Mycobacterium tuberculosis and helminth infections on the development of allergic asthma, as well as possible pathways for preventing allergic asthma through vaccine design.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Danijela Apostolovic, Jeanette Grundstrom, Mensiena B. Gea Kiewiet, Marija Perusko, Carl Hamsten, Maria Starkhammar, Staffan Paulie, Marianne van Hage
Summary: This study investigated T and B cell responses to tick protein extract (TE) and alpha-Gal-free TE in patients with AGS and healthy controls. The results showed that T and B cells proliferated more in patients with AGS compared to controls in response to TE. B cell proliferation in patients with AGS was reduced by removing alpha-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. These findings are essential for understanding the immune response against an allergenic carbohydrate transmitted by ticks.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Allergy
Atsuhito Nakao, Yuki Nakamura
Summary: Mast cell activation plays a crucial role in the development of allergic diseases. Recent studies have revealed that mast cell activation, both IgE-dependent and -independent, is temporally regulated by the circadian clock. This regulation is associated with the day-night changes in symptom occurrence and severity of allergic diseases. Factors that disturb the circadian rhythm, such as irregular eating habits, can lead to the loss of control over mast cell activation, resulting in worsened allergic symptoms.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Oncology
Regina Heidenreich, Edith Jasny, Aleksandra Kowalczyk, Johannes Lutz, Jochen Probst, Patrick Baumhof, Birgit Scheel, Soehnke Voss, Karl-Josef Kallen, Mariola Fotin-Mleczek
INTERNATIONAL JOURNAL OF CANCER
(2015)
Article
Multidisciplinary Sciences
Johannes Lutz, Kai Dittmann, Michael R. Boesl, Thomas H. Winkler, Juergen Wienands, Niklas Engels
NATURE COMMUNICATIONS
(2015)
Article
Immunology
Johannes Lutz, Sandra Lazzaro, Mohamed Habbeddine, Kim Ellen Schmidt, Patrick Baumhof, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Michael J. Hope, Regina Heidenreich, Mariola Fotin-Mleczek
Article
Immunology
Niklas Engels, Lars Morten Koenig, Christina Heemann, Johannes Lutz, Takeshi Tsubata, Sebastian Griep, Verena Schrader, Juergen Wienands
Article
Multidisciplinary Sciences
Johannes Lutz, Marinus R. Heideman, Edith Roth, Paul van den Berk, Werner Mueller, Chander Ramand, Matthias Wabl, Heinz Jacobs, Hans-Martin Jaeck
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Multidisciplinary Sciences
Pamela A. Frischmeyer-Guerrerio, Robert A. Montgomery, Daniel S. Warren, Sara K. Cooke, Johannes Lutz, Christopher J. Sonnenday, Anthony L. Guerrerio, Harry C. Dietz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Multidisciplinary Sciences
Niklas Engels, Lars M. Koenig, Wiebke Schulze, Daniel Radtke, Kanika Vanshylla, Johannes Lutz, Thomas H. Winkler, Lars Nitschke, Juergen Wienands
NATURE COMMUNICATIONS
(2014)
Article
Immunology
Paul Haase, Lavanya Mokada-Gopal, Daniel Radtke, David Voehringer
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Review
Immunology
Paul Haase, David Voehringer
Summary: The type 2 immune response is characterized by the production of IgG1 and IgE antibodies, which play a role in protective or proinflammatory functions. Recent studies have uncovered important insights into the regulatory mechanisms controlling humoral type 2 immunity, including signals from T-helper cells and intrinsic factors in B cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Johannes Lutz, Michael Meister, Mohamed Habbeddine, Katja Fiedler, Aleksandra Kowalczyk, Regina Heidenreich
Summary: Immunotherapy has revolutionized cancer treatment, but not all patients benefit from it. Direct injection of RNA-based immune stimulator CV8102 into tumors can activate immune responses and enhance the effectiveness of immunotherapy. Additionally, combining it with systemic checkpoint inhibitors further boosts anti-tumoral responses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Christian Vettermann, Johannes Lutz, Manuel Selg, Michael Boesl, Hans-Martin Jaeck
EUROPEAN JOURNAL OF IMMUNOLOGY
(2006)
Article
Immunology
Johannes Lutz, Werner Muller, Hans-Martin Jack
JOURNAL OF IMMUNOLOGY
(2006)
Article
Immunology
E Paul, J Lutz, J Erikson, MC Carroll
INTERNATIONAL IMMUNOLOGY
(2004)