Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure

(2019) Brendan M. Everett et al.   CIRCULATION

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity

(2019) Michele Russo et al.   EUROPEAN JOURNAL OF HEART FAILURE

2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy

(2019) Jeffrey A. Towbin et al.   HEART RHYTHM

Nitrosative stress drives heart failure with preserved ejection fraction

(2019) Gabriele G. Schiattarella et al.   NATURE

Current Landscape of Heart Failure Gene Therapy

(2019) Jake M. Kieserman et al.   Journal of the American Heart Association

Cardiovascular nanomedicine: the route ahead

(2019) Michele Iafisco et al.   Nanomedicine

Female Sex Is Protective in a Preclinical Model of Heart Failure With Preserved Ejection Fraction

(2019) Dan Tong et al.   CIRCULATION

The gut microbiome and heart failure: A better gut for a better heart

(2019) Maxime Branchereau et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth

(2018) Mingchuan Li et al.   CIRCULATION

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

(2018) Dian J. Cao et al.   CIRCULATION

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

(2018) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

Autophagy and proinflammatory cytokines: Interactions and clinical implications

(2018) Yun Ge et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Heart failure with preserved ejection fraction: from mechanisms to therapies

(2018) Carolyn S P Lam et al.   EUROPEAN HEART JOURNAL

Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG)

(2018) Ray E. Hershberger et al.   GENETICS IN MEDICINE

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

(2018) Alessandra Marrella et al.   Journal of the Royal Society Interface

Inhalation of peptide-loaded nanoparticles improves heart failure

(2018) Michele Miragoli et al.   Science Translational Medicine

Applications of nanoparticle systems in drug delivery technology

(2018) Syed A.A. Rizvi et al.   SAUDI PHARMACEUTICAL JOURNAL

Novel Beneficial Cardiovascular Effects of Natural Activators of Autophagy

(2018) Giacomo Frati et al.   CIRCULATION RESEARCH

Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases

(2018) Gabriele G. Schiattarella et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Dietary metabolism, the gut microbiome, and heart failure

(2018) W. H. Wilson Tang et al.   Nature Reviews Cardiology

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes

(2017) Roddy Walsh et al.   EUROPEAN HEART JOURNAL

Desmoplakin missense and non-missense mutations in arrhythmogenic right ventricular cardiomyopathy: Genotype-phenotype correlation

(2017) Silvia Castelletti et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions

(2017) Paul M. Ryan et al.   Diabetology & Metabolic Syndrome

Identification of Cadherin 2 ( CDH2 ) Mutations in Arrhythmogenic Right Ventricular CardiomyopathyCLINICAL PERSPECTIVE

(2017) Bongani M. Mayosi et al.   Circulation-Cardiovascular Genetics

The Metabolodiuretic Promise of Sodium-Dependent Glucose Cotransporter 2 Inhibition

(2017) Subodh Verma et al.   JAMA Cardiology

Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy

(2016) J. J. Bartlett et al.   BIOCHEMICAL JOURNAL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

Aging and Autophagy in the Heart

(2016) Akihiro Shirakabe et al.   CIRCULATION RESEARCH

Therapeutic targeting of autophagy in cardiovascular disease

(2016) Gabriele G. Schiattarella et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy

(2016) Michael A. Burke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

(2016) Barry Greenberg et al.   LANCET

Bioinspired negatively charged calcium phosphate nanocarriers for cardiac delivery of MicroRNAs

(2016) Vittoria Di Mauro et al.   Nanomedicine

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies

(2016) Maryam Fish et al.   Scientific Reports

Pathogenic Gut Flora in Patients With Chronic Heart Failure

(2016) Evasio Pasini et al.   JACC-Heart Failure

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

(2015) T. Saito et al.   CIRCULATION RESEARCH

Innate Immunity and the Failing Heart

(2015) Douglas L. Mann   CIRCULATION RESEARCH

2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

(2015) Silvia G. Priori et al.   EUROPEAN HEART JOURNAL

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity

(2015) Ahmed A. Alfares et al.   GENETICS IN MEDICINE

The war against heart failure: the Lancet lecture

(2015) Eugene Braunwald   LANCET

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure

(2014) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

(2014) Christoph Bantz et al.   Beilstein Journal of Nanotechnology

Effects of Interleukin-1 Blockade With Anakinra on Aerobic Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction (from the D-HART Pilot Study)

(2013) Benjamin Wallace Van Tassell et al.   AMERICAN JOURNAL OF CARDIOLOGY

Activation of NADPH Oxidase 4 in the Endoplasmic Reticulum Promotes Cardiomyocyte Autophagy and Survival During Energy Stress Through the Protein Kinase RNA-Activated-Like Endoplasmic Reticulum Kinase/Eukaryotic Initiation Factor 2α/Activating Transcription Factor 4 Pathway

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy

(2013) Benjamin Meder et al.   EUROPEAN HEART JOURNAL

Clinical predictors of genetic testing outcomes in hypertrophic cardiomyopathy

(2013) Jodie Ingles et al.   GENETICS IN MEDICINE

Cytotoxicity and Cell Interaction Studies of Bioadhesive Poly(anhydride) Nanoparticles for Oral Antigen/Drug Delivery

(2013) Patricia Ojer et al.   Journal of Biomedical Nanotechnology

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy

(2012) Jolanda van Hengel et al.   EUROPEAN HEART JOURNAL

A histone deacetylase inhibitory prodrug – Butyroyloxymethyl diethyl phosphate – Protects the heart and cardiomyocytes against ischemia injury

(2012) G. Kessler-Icekson et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inherited Cardiomyopathies

(2012) Polakit Teekakirikul et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival

(2012) Eisuke Dohi et al.   NEUROCHEMISTRY INTERNATIONAL

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation, Characterization, Pharmacokinetics and Tissue Distribution of Solid Lipid Nanoparticles Loaded with Tetrandrine

(2011) Su Li et al.   AAPS PHARMSCITECH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Atg7 Induces Basal Autophagy and Rescues Autophagic Deficiency in CryAB R120G Cardiomyocytes

(2011) J. Scott Pattison et al.   CIRCULATION RESEARCH

HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)

(2011) M. J. Ackerman et al.   EUROPACE

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms

(2011) Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure

(2010) Anja Sandek et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Compound and Digenic Heterozygosity Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy

(2010) Tianhong Xu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

(2010) Karl Swedberg et al.   LANCET

Lamin A/C deficiency as a cause of familial dilated cardiomyopathy

(2009) Rohit Malhotra et al.   CURRENT OPINION IN CARDIOLOGY

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline

(2009) Ray E. Hershberger et al.   JOURNAL OF CARDIAC FAILURE

Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?

(2008) Constantinos Pantos et al.   BASIC RESEARCH IN CARDIOLOGY

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy

(2008) Christian Geier et al.   HUMAN MOLECULAR GENETICS

Nanovehicular Intracellular Delivery Systems

(2008) Ales Prokop et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Autophagy is an adaptive response in desmin-related cardiomyopathy

(2008) P. Tannous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA