Transcriptional and Metabolomic Analysis of L-Arginine/Nitric Oxide Pathway in Inflammatory Bowel Disease and Its Association with Local Inflammatory and Angiogenic Response: Preliminary Findings

Inhibition of Dimethylarginine Dimethylaminohydrolase (DDAH) Enzymes as an Emerging Therapeutic Strategy to Target Angiogenesis and Vasculogenic Mimicry in Cancer

(2020) Julie-Ann Hulin et al.   Frontiers in Oncology

Oversecretion and Overexpression of Nicotinamide Phosphoribosyltransferase/Pre-B Colony-Enhancing Factor/Visfatin in Inflammatory Bowel Disease Reflects the Disease Activity, Severity of Inflammatory Response and Hypoxia

(2019) Katarzyna Neubauer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome

(2019) Kshipra Singh et al.   Frontiers in Cellular and Infection Microbiology

The role of polyamines in the regulation of macrophage polarization and function

(2019) Yvonne L. Latour et al.   AMINO ACIDS

Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS)

(2019) Małgorzata Krzystek-Korpacka et al.   Oxidative Medicine and Cellular Longevity

Arginine metabolism and deprivation in cancer therapy

(2019) Songyun Zou et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeted metabolomic analysis of nitric oxide/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes

(2019) Mariusz G. Fleszar et al.   Scientific Reports

Splicing Dysregulation as Oncogenic Driver and Passenger Factor in Brain Tumors

(2019) Pamela Bielli et al.   Cells

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

(2018) Kshipra Singh et al.   CANCER RESEARCH

Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography–Mass Spectrometric Method

(2018) Mariusz G. Fleszar et al.   CHROMATOGRAPHIA

Arginase: A Multifaceted Enzyme Important in Health and Disease

(2018) R. William Caldwell et al.   PHYSIOLOGICAL REVIEWS

Asymmetric and symmetric dimethylarginines and mortality in patients with hematological malignancies—A prospective study

(2018) Angelika Chachaj et al.   PLoS One

Arginine and the metabolic regulation of nitric oxide synthesis in cancer

(2018) Rom Keshet et al.   Disease Models & Mechanisms

Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis

(2018) Lori A. Coburn et al.   ONCOGENE

The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting

(2018) Luciano Pirola et al.   Cancers

DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

(2018) Zhen‑Dong Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer

(2018) Eugene W. Gerner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

(2018) Sara Lovisa et al.   Journal of Crohns & Colitis

Metabolic pathways of L-arginine and therapeutic consequences in tumors

(2018) Jarosław Szefel et al.   Advances in Medical Sciences

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Arginine Methylation: The Coming of Age

(2017) Roméo S. Blanc et al.   MOLECULAR CELL

DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway

(2017) Jianxin Ye et al.   Molecular Oncology

Toxic Dimethylarginines: Asymmetric  Dimethylarginine (ADMA) and Symmetric  Dimethylarginine (SDMA)

(2017) You‐Lin Tain et al.   Toxins

Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis

(2017) Konstantinos C. Fragkos et al.   United European Gastroenterology Journal

Protein Arginine Methyltransferase 5 Inhibition Upregulates Foxp3+ Regulatory T Cells Frequency and Function during the Ulcerative Colitis

(2017) Yingxia Zheng et al.   Frontiers in Immunology

Nitric oxide as a potential biomarker in inflammatory bowel disease

(2017) Nesina Avdagić et al.   Bosnian Journal of Basic Medical Sciences

Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA

(2017) Zhiwen Fan et al.   Scientific Reports

Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II

(2016) Bhuvana A. Setty et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis

(2016) Lori A. Coburn et al.   INFLAMMATORY BOWEL DISEASES

Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation

(2016) Manuel Lasch et al.   LABORATORY INVESTIGATION

Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response

(2016) Anja Reintjes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and Molecular Mediators of Intestinal Fibrosis

(2015) Ian C. Lawrance et al.   Journal of Crohns & Colitis

Chronic inflammation and the development of malignancy in the GI tract

(2015) Stefan Fichtner-Feigl et al.   TRENDS IN IMMUNOLOGY

Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma

(2015) Toshihiro Shiozawa et al.   VIRCHOWS ARCHIV

Expression Stability of Common Housekeeping Genes Is Differently Affected by Bowel Inflammation and Cancer

(2014) Malgorzata Krzystek-Korpacka et al.   INFLAMMATORY BOWEL DISEASES

Colorectal cancer in inflammatory bowel disease: The risk, pathogenesis, prevention and diagnosis

(2014) Eun Ran Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein

(2013) J Zhong et al.   ONCOGENE

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs

(2013) Evrim Gurpinar et al.   Frontiers in Oncology

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

(2012) Tong-You W. Wei et al.   CANCER SCIENCE

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Autoimmune Diseases and Polyamines

(2011) Wesley H. Brooks   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Agmatine (decarboxylated l-arginine): Physiological role and therapeutic potential

(2011) Gerhard J. Molderings et al.   PHARMACOLOGY & THERAPEUTICS

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

Arginine methylation in interferon signaling: New light on an old story

(2010) Susanne Weber et al.   CELL CYCLE

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and 8-iso-prostaglandin F2α (8-iso-PGF2α) level in patients with inflammatory bowel diseases

(2009) Danuta Owczarek et al.   INFLAMMATORY BOWEL DISEASES

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

(2009) A. Scoumanne et al.   NUCLEIC ACIDS RESEARCH

Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5

(2008) Alexander-Francisco Bruns et al.   BIOLOGICAL CHEMISTRY

Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

(2008) Frank L. Meyskens et al.   Cancer Prevention Research