Engineering Prostate Cancer from Induced Pluripotent Stem Cells—New Opportunities to Develop Preclinical Tools in Prostate and Prostate Cancer Studies

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Renal control of disease tolerance to malaria

(2019) Susana Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

(2019) Yohei Korogi et al.   Stem Cell Reports

Abiraterone in “High-” and “Low-risk” Metastatic Hormone-sensitive Prostate Cancer

(2019) Alex P. Hoyle et al.   EUROPEAN UROLOGY

Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial

(2019) N W Clarke et al.   ANNALS OF ONCOLOGY

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

(2019) Sandra Lawrynowicz Leibel et al.   Scientific Reports

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

(2019) Solvig Diederichs et al.   Frontiers in Cell and Developmental Biology

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

(2018) Thomas A. Forbes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Comparative Assay of 2D and 3D Cell Culture Models: Proliferation, Gene Expression and Anticancer Drug Response

(2018) Aline G. Souza et al.   CURRENT PHARMACEUTICAL DESIGN

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology

(2018) Philipp Nuhn et al.   EUROPEAN UROLOGY

Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study

(2018) Rahul Aggarwal et al.   JOURNAL OF CLINICAL ONCOLOGY

The long tail of oncogenic drivers in prostate cancer

(2018) Joshua Armenia et al.   NATURE GENETICS

Cellular plasticity and the neuroendocrine phenotype in prostate cancer

(2018) Alastair H. Davies et al.   Nature Reviews Urology

Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency

(2018) Dean Hallam et al.   STEM CELLS

Preclinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids, and Other Explant Models

(2018) Gail P. Risbridger et al.   Cold Spring Harbor Perspectives in Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Managing Nonmetastatic Castration-resistant Prostate Cancer

(2018) Joaquin Mateo et al.   EUROPEAN UROLOGY

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma

(2018) Duangporn Saengwimol et al.   Scientific Reports

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives

(2018) Sylvia J. Gasparini et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

(2018) Adriana Buskin et al.   Nature Communications

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome

(2018) Su Su et al.   Cell Reports

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions

(2017) Yuchen Xia et al.   JOURNAL OF HEPATOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids

(2017) Kenji Unno et al.   Oncotarget

Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing

(2017) Myungshin Kim et al.   Scientific Reports

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

(2017) Mohammad Moad et al.   Cell Reports

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

Efficient Large-Scale 2D Culture System for Human Induced Pluripotent Stem Cells and Differentiated Cardiomyocytes

(2017) Shugo Tohyama et al.   Stem Cell Reports

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

hPSC-derived lung and intestinal organoids as models of human fetal tissue

(2016) Megan Aurora et al.   DEVELOPMENTAL BIOLOGY

Subrenal capsule grafting technology in human cancer modeling and translational cancer research

(2016) Yuzhuo Wang et al.   DIFFERENTIATION

Translation of Human-Induced Pluripotent Stem Cells

(2016) Nazish Sayed et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

(2016) Freddie C. Hamdy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

(2016) Jennifer L. Bishop et al.   Cancer Discovery

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Quantification of regenerative potential in primary human mammary epithelial cells

(2015) J. R. Linnemann et al.   DEVELOPMENT

Building the foundation for genomics in precision medicine

(2015) Samuel J. Aronson et al.   NATURE

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure

(2015) Esther L. Calderon-Gierszal et al.   PLoS One

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer

(2015) Dong Lin et al.   Oncotarget

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Single luminal epithelial progenitors can generate prostate organoids in culture

(2014) Chee Wai Chua et al.   NATURE CELL BIOLOGY

Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer

(2014) Anna Bill-Axelson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Directed Differentiation of Pluripotent Stem Cells to Kidney Cells

(2014) Albert Q. Lam et al.   SEMINARS IN NEPHROLOGY

Comparing ESC and iPSC—Based Models for Human Genetic Disorders

(2014) Tomer Halevy et al.   Journal of Clinical Medicine

High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

(2013) D. Lin et al.   CANCER RESEARCH

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

(2013) BRUNA COROMINAS-FAJA et al.   CELL CYCLE

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

A Novel Model of Urinary Tract Differentiation, Tissue Regeneration, and Disease: Reprogramming Human Prostate and Bladder Cells into Induced Pluripotent Stem Cells

(2013) Mohammad Moad et al.   EUROPEAN UROLOGY

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

(2013) S. H. Stricker et al.   GENES & DEVELOPMENT

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Breaking through a roadblock in prostate cancer research: An update on human model systems

(2012) R. Toivanen et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Programming human pluripotent stem cells into white and brown adipocytes

(2012) Tim Ahfeldt et al.   NATURE CELL BIOLOGY

Drug development and clinical trials—the path to an approved cancer drug

(2012) Eric H. Rubin et al.   Nature Reviews Clinical Oncology

The complexity of prostate cancer: genomic alterations and heterogeneity

(2012) Lara K. Boyd et al.   Nature Reviews Urology

Radical Prostatectomy versus Observation for Localized Prostate Cancer

(2012) Timothy J. Wilt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

(2012) Howard I. Scher et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Human Atrial Action Potential and Ca 2+ Model

(2011) Eleonora Grandi et al.   CIRCULATION RESEARCH

Abiraterone and Increased Survival in Metastatic Prostate Cancer

(2011) Johann S. de Bono et al.   NEW ENGLAND JOURNAL OF MEDICINE

Brief Report: A Bioassay to Identify Primary Human Prostate Cancer Repopulating Cells

(2011) Roxanne Toivanen et al.   STEM CELLS

Generation of iPSCs from cultured human malignant cells

(2010) J. E. Carette et al.   BLOOD

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Development of metastatic and non-metastatic tumor lines from a patient's prostate cancer specimen-identification of a small subpopulation with metastatic potential in the primary tumor

(2010) Dong Lin et al.   PROSTATE

Identification of a Cell of Origin for Human Prostate Cancer

(2010) A. S. Goldstein et al.   SCIENCE

Robust Enhancement of Neural Differentiation from Human ES and iPS Cells Regardless of their Innate Difference in Differentiation Propensity

(2010) Dae-Sung Kim et al.   Stem Cell Reviews and Reports

Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

(2009) Jianhua Zhang et al.   CIRCULATION RESEARCH

Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells

(2009) J. Utikal et al.   JOURNAL OF CELL SCIENCE

Clinical Results of Long-Term Follow-Up of a Large, Active Surveillance Cohort With Localized Prostate Cancer

(2009) Laurence Klotz et al.   JOURNAL OF CLINICAL ONCOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Defined factors induce reprogramming of gastrointestinal cancer cells

(2009) N. Miyoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance

(2008) S. M. Dehm et al.   CANCER RESEARCH

Targeting the androgen receptor pathway in prostate cancer

(2008) Yu Chen et al.   CURRENT OPINION IN PHARMACOLOGY

Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state

(2008) S.-L. Lin et al.   RNA

Role of the TMPRSS2-ERG Gene Fusion in Prostate Cancer

(2008) Scott A. Tomlins et al.   NEOPLASIA