The Role of Connexin Channels in the Response of Mechanical Loading and Unloading of Bone

Fluid shear stress improves morphology, cytoskeleton architecture, viability and regulates cytokine expression in a time-dependent manner in MLO-Y4 cells

(2018) Zedong Yan et al.   CELL BIOLOGY INTERNATIONAL

Connexin43 Carboxyl-Terminal Domain Directly Interacts with β-Catenin

(2018) Gaelle Spagnol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation

(2017) Megan C. Moorer et al.   JOURNAL OF CELL SCIENCE

Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis

(2017) Kyu Sang Joeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Biological responses of osteocytic connexin 43 hemichannels to simulated microgravity

(2017) Huiyun Xu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling

(2017) Susan K. Grimston et al.   PLoS One

The potential role of spectrin network in the mechanotransduction of MLO-Y4 osteocytes

(2017) Xin-Tong Wu et al.   Scientific Reports

Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?

(2017) Mauricio A. Retamal et al.   Frontiers in Molecular Neuroscience

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes

(2016) Wing Yee Cheung et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Connexins and pannexins in the skeleton: gap junctions, hemichannels and more

(2015) Lilian I. Plotkin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress

(2015) Manuel A. Riquelme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Channels Are Essential for Normal Bone Structure and Osteocyte Viability

(2015) Huiyun Xu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures

(2015) Tanya Zappitelli et al.   MOLECULAR BIOLOGY OF THE CELL

Syndromic and non-syndromic disease-linked Cx43 mutations

(2014) Dale W. Laird   FEBS LETTERS

Gap junctional regulation of signal transduction in bone cells

(2014) Atum M. Buo et al.   FEBS LETTERS

Direct Regulation of Osteocytic Connexin 43 Hemichannels through AKT Kinase Activated by Mechanical Stimulation

(2014) Nidhi Batra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation

(2014) Rafael Pacheco-Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling

(2013) Shane A. Lloyd et al.   BONE

The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age-related bone loss

(2013) Tanya Zappitelli et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Shifting Paradigms on the Role of Connexin43 in the Skeletal Response to Mechanical Load

(2013) Shane A Lloyd et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

(2013) Behzad Javaheri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

14-3-3  facilitates plasma membrane delivery and function of mechanosensitive connexin 43 hemichannels

(2013) N. Batra et al.   JOURNAL OF CELL SCIENCE

Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice

(2013) Nicoletta Bivi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A Novel Autosomal Recessive GJA1 Missense Mutation Linked to Craniometaphyseal Dysplasia

(2013) Ying Hu et al.   PLoS One

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require  V 3 integrin

(2013) M. M. Thi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological role of connexin intercellular channels and hemichannels

(2012) Rekha Kar et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Calcium response in osteocytic networks under steady and oscillatory fluid flow

(2012) X. Lucas Lu et al.   BONE

Deletion of Cx43 from Osteocytes Results in Defective Bone Material Properties but Does Not Decrease Extrinsic Strength in Cortical Bone

(2012) Nicoletta Bivi et al.   CALCIFIED TISSUE INTERNATIONAL

Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading

(2012) Shane A Lloyd et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Connexin43 and Pannexin1 Channels in Osteoblasts: Who Is the “Hemichannel”?

(2012) Mia M. Thi et al.   JOURNAL OF MEMBRANE BIOLOGY

Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice

(2012) Susan K. Grimston et al.   PLoS One

Mechanical stress-activated integrin  5 1 induces opening of connexin 43 hemichannels

(2012) N. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graviresponses of osteocytes under altered gravity

(2011) S.M. Di et al.   ADVANCES IN SPACE RESEARCH

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis

(2011) Susan K Grimston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

(2011) Nicoletta Bivi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling

(2011) Marcus Watkins et al.   MOLECULAR BIOLOGY OF THE CELL

Enhanced Osteoclastic Resorption and Responsiveness to Mechanical Load in Gap Junction Deficient Bone

(2011) Yue Zhang et al.   PLoS One

Osteocyte Mechanobiology and Pericellular Mechanics

(2010) Christopher R. Jacobs et al.   Annual Review of Biomedical Engineering

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation

(2010) Jun Guo et al.   Cell Metabolism

Regulatory Mechanism of Osteoclastogenesis by RANKL and Wnt Signals

(2010) Naoyuki Takahashi   Frontiers in Bioscience-Landmark

Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways

(2010) Yukiko Kitase et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

(2010) S. Burra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal Effects of Long-Duration Head-Down Bed Rest

(2009) Elisabeth R. Spector et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

(2009) Ana Santos et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Reduction in proximal femoral strength due to long-duration spaceflight

(2008) J.H. Keyak et al.   BONE