Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 1, Pages 214
Publisher
MDPI AG
Online
2019-12-28
DOI
10.3390/ijms21010214
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Evidence to date: talazoparib in the treatment of breast cancer
- (2019) Pedro Exman et al. OncoTargets and Therapy
- A rapid fluorescent method for the real-time measurement of poly(ADP-ribose) polymerase 1 activity
- (2018) T.A. Kurgina et al. ANALYTICAL BIOCHEMISTRY
- Effective Synthesis of 5-Iodo Derivatives of Pyrimidine Morpholino Nucleosides
- (2018) Ivan P. Vohtancev et al. ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
- NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains
- (2018) Marie-France Langelier et al. Nature Communications
- Dna is a New Target of Parp3
- (2018) E. A. Belousova et al. Scientific Reports
- PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines
- (2018) Bahram Sharif-Askari et al. BREAST CANCER RESEARCH AND TREATMENT
- PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
- (2017) Rebecca Gupte et al. GENES & DEVELOPMENT
- Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities
- (2017) Jyotika Rajawat et al. MEDICINAL RESEARCH REVIEWS
- Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3′-Homologated Nucleoside Amino Acids
- (2017) Venubabu Kotikam et al. ORGANIC LETTERS
- Synthesis and antiproliferative evaluation of novel azido nucleosides and their phosphoramidate derivatives
- (2017) Nuno M. Xavier et al. PURE AND APPLIED CHEMISTRY
- Synthesis of a series of NAD+ analogues, potential inhibitors of PARP 1, using ADP conjugates functionalized at the terminal phosphate group
- (2017) Yu. V. Sherstyuk et al. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
- Current status of poly(ADP-ribose) polymerase inhibitors and future directions
- (2017) Akihiro Ohmoto et al. OncoTargets and Therapy
- Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation
- (2016) Annette Buntz et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer
- (2016) Qin Zhou et al. BIOCHEMICAL PHARMACOLOGY
- Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation
- (2016) Hui Li et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models
- (2016) L. Oplustil O'Connor et al. CANCER RESEARCH
- PARP inhibitors as antitumor agents: a patent update (2013-2015)
- (2016) Zigao Yuan et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
- (2016) Ann-Gerd Thorsell et al. JOURNAL OF MEDICINAL CHEMISTRY
- A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors
- (2016) Yuliya V. Sherstyuk et al. MOLECULAR DIVERSITY
- Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives
- (2016) Yuliya V. Tarasenko et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
- (2016) B. A. Gibson et al. SCIENCE
- Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy
- (2015) Gianluca Papeo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent
- (2015) Bing Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases
- (2015) Giulia Pergolizzi et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics
- (2014) Tatyana V Abramova et al. Beilstein Journal of Organic Chemistry
- A Tractable and Efficient One-Pot Synthesis of 5'-Azido-5'-deoxyribonucleosides
- (2014) Theodore Peterson et al. MOLECULES
- Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
- (2014) Shengjun Wang et al. MOLECULES
- Family-wide analysis of poly(ADP-ribose) polymerase activity
- (2014) Sejal Vyas et al. Nature Communications
- PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3
- (2013) Anders E. G. Lindgren et al. ACS Chemical Biology
- PARP inhibitors: polypharmacology versus selective inhibition
- (2013) Torun Ekblad et al. FEBS Journal
- Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
- (2013) Lars Petter Jordheim et al. NATURE REVIEWS DRUG DISCOVERY
- Disaccharide Pyrimidine Nucleosides and Their Derivatives: A Novel Group of Cell-Penetrating Inhibitors of Poly(ADP-Ribose) Polymerase 1
- (2013) Anna S. Efremova et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- A systematic analysis of the PARP protein family identifies new functions critical for cell physiology
- (2013) Sejal Vyas et al. Nature Communications
- Structural Implications for Selective Targeting of PARPs
- (2013) Jamin D. Steffen et al. Frontiers in Oncology
- 3′-5′ Phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1in vivo
- (2012) Elie Toledano et al. BIOCHEMICAL JOURNAL
- Natural Inhibitors of Poly(ADP-ribose) Polymerase-1
- (2012) Marek Banasik et al. MOLECULAR NEUROBIOLOGY
- PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and mitotic progression
- (2011) Christian Boehler et al. CELL CYCLE
- Nine Enzymes Are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics
- (2011) Wenjun Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888
- (2010) Tobias Karlberg et al. BIOCHEMISTRY
- Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics
- (2010) Amy E. Trunkfield et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic
- (2010) Dana V. Ferraris JOURNAL OF MEDICINAL CHEMISTRY
- Toward a unified nomenclature for mammalian ADP-ribosyltransferases
- (2010) Michael O. Hottiger et al. TRENDS IN BIOCHEMICAL SCIENCES
- Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors
- (2009) Kar Kheng Yeoh et al. CARBOHYDRATE RESEARCH
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started