Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3

Evidence to date: talazoparib in the treatment of breast cancer

(2019) Pedro Exman et al.   OncoTargets and Therapy

A rapid fluorescent method for the real-time measurement of poly(ADP-ribose) polymerase 1 activity

(2018) T.A. Kurgina et al.   ANALYTICAL BIOCHEMISTRY

Effective Synthesis of 5-Iodo Derivatives of Pyrimidine Morpholino Nucleosides

(2018) Ivan P. Vohtancev et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

(2018) Marie-France Langelier et al.   Nature Communications

Dna is a New Target of Parp3

(2018) E. A. Belousova et al.   Scientific Reports

PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines

(2018) Bahram Sharif-Askari et al.   BREAST CANCER RESEARCH AND TREATMENT

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities

(2017) Jyotika Rajawat et al.   MEDICINAL RESEARCH REVIEWS

Concurrent Hydrogenation of Three Functional Groups Enables Synthesis of C3′-Homologated Nucleoside Amino Acids

(2017) Venubabu Kotikam et al.   ORGANIC LETTERS

Synthesis and antiproliferative evaluation of novel azido nucleosides and their phosphoramidate derivatives

(2017) Nuno M. Xavier et al.   PURE AND APPLIED CHEMISTRY

Synthesis of a series of NAD+ analogues, potential inhibitors of PARP 1, using ADP conjugates functionalized at the terminal phosphate group

(2017) Yu. V. Sherstyuk et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Current status of poly(ADP-ribose) polymerase inhibitors and future directions

(2017) Akihiro Ohmoto et al.   OncoTargets and Therapy

Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation

(2016) Annette Buntz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer

(2016) Qin Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation

(2016) Hui Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

(2016) L. Oplustil O'Connor et al.   CANCER RESEARCH

PARP inhibitors as antitumor agents: a patent update (2013-2015)

(2016) Zigao Yuan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors

(2016) Ann-Gerd Thorsell et al.   JOURNAL OF MEDICINAL CHEMISTRY

A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors

(2016) Yuliya V. Sherstyuk et al.   MOLECULAR DIVERSITY

Effective Synthesis of Fluorescently Labeled Morpholino Nucleoside Triphosphate Derivatives

(2016) Yuliya V. Tarasenko et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

(2016) B. A. Gibson et al.   SCIENCE

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

(2015) Gianluca Papeo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent

(2015) Bing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases

(2015) Giulia Pergolizzi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solid-phase-supported synthesis of morpholinoglycine oligonucleotide mimics

(2014) Tatyana V Abramova et al.   Beilstein Journal of Organic Chemistry

A Tractable and Efficient One-Pot Synthesis of 5'-Azido-5'-deoxyribonucleosides

(2014) Theodore Peterson et al.   MOLECULES

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

(2014) Shengjun Wang et al.   MOLECULES

Family-wide analysis of poly(ADP-ribose) polymerase activity

(2014) Sejal Vyas et al.   Nature Communications

PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3

(2013) Anders E. G. Lindgren et al.   ACS Chemical Biology

PARP inhibitors: polypharmacology versus selective inhibition

(2013) Torun Ekblad et al.   FEBS Journal

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Disaccharide Pyrimidine Nucleosides and Their Derivatives: A Novel Group of Cell-Penetrating Inhibitors of Poly(ADP-Ribose) Polymerase 1

(2013) Anna S. Efremova et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology

(2013) Sejal Vyas et al.   Nature Communications

Structural Implications for Selective Targeting of PARPs

(2013) Jamin D. Steffen et al.   Frontiers in Oncology

3′-5′ Phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1in vivo

(2012) Elie Toledano et al.   BIOCHEMICAL JOURNAL

Natural Inhibitors of Poly(ADP-ribose) Polymerase-1

(2012) Marek Banasik et al.   MOLECULAR NEUROBIOLOGY

PARP-3, a DNA-dependent PARP with emerging roles in double-strand break repair and mitotic progression

(2011) Christian Boehler et al.   CELL CYCLE

Nine Enzymes Are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics

(2011) Wenjun Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structure of the Catalytic Domain of Human PARP2 in Complex with PARP Inhibitor ABT-888

(2010) Tobias Karlberg et al.   BIOCHEMISTRY

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics

(2010) Amy E. Trunkfield et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic

(2010) Dana V. Ferraris   JOURNAL OF MEDICINAL CHEMISTRY

Toward a unified nomenclature for mammalian ADP-ribosyltransferases

(2010) Michael O. Hottiger et al.   TRENDS IN BIOCHEMICAL SCIENCES

Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors

(2009) Kar Kheng Yeoh et al.   CARBOHYDRATE RESEARCH