Base-modified NAD and AMP derivatives and their activity against bacterial DNA ligases

Identification through structure-based methods of a bacterial NAD+-dependent DNA ligase inhibitor that avoids known resistance mutations

(2013) Kerry Murphy-Benenato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fragment-Based Discovery of 6-Azaindazoles As Inhibitors of Bacterial DNA Ligase

(2013) Steven Howard et al.   ACS Medicinal Chemistry Letters

Structure Guided Understanding of NAD+ Recognition in Bacterial DNA Ligases

(2012) Sushmita D. Lahiri et al.   ACS Chemical Biology

Mechanistic Assessment of DNA Ligase as an Antibacterial Target in Staphylococcus aureus

(2012) Steven D. Podos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds

(2012) Haris Jahić et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis and biological evaluation of potent NAD+-dependent DNA ligase inhibitors as potential antibacterial agents. Part I: Aminoalkoxypyrimidine carboxamides

(2012) Wenxin Gu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity

(2012) Jean-Philippe Surivet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Selective Synthesis of Metallanucleosides and Metallanucleotides: A New Tool for the Functionalization of Nucleic Acids

(2012) Mamen Martín-Ortíz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bacterial DNA replication enzymes as targets for antibacterial drug discovery

(2012) Gautam Sanyal et al.   Expert Opinion on Drug Discovery

Antimicrobial Activity of Adenine-Based Inhibitors of NAD+-Dependent DNA Ligase

(2012) Ed T. Buurman et al.   ACS Medicinal Chemistry Letters

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity

(2011) Suzanne S. Stokes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Improvements in clearance of adenosine series

(2011) Suzanne S. Stokes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel fluorescent probe for NAD-consuming enzymes

(2011) Giulia Pergolizzi et al.   CHEMICAL COMMUNICATIONS

Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)

(2011) Thomas Pesnot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial EfficacyIn Vivo

(2010) Scott D. Mills et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DNA Ligases: Progress and Prospects

(2009) Stewart Shuman   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Synthesis and biological evaluation of novel neamine–nucleoside conjugates potentially targeting to RNAs

(2009) Yanli Xu et al.   TETRAHEDRON

DNA and RNA ligases: structural variations and shared mechanisms

(2008) John M Pascal   CURRENT OPINION IN STRUCTURAL BIOLOGY

2′-Deoxy Cyclic Adenosine 5′-Diphosphate Ribose Derivatives: Importance of the 2′-Hydroxyl Motif for the Antagonistic Activity of 8-Substituted cADPR Derivatives

(2008) Bo Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Siderophore Biosynthesis inMycobacterium tuberculosiswith Nucleoside Bisubstrate Analogues: Structure−Activity Relationships of the Nucleobase Domain of 5′-O-[N-(Salicyl)sulfamoyl]adenosine

(2008) João Neres et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Sugar Nucleotides by Application of Phosphoramidites

(2008) Henrik Gold et al.   JOURNAL OF ORGANIC CHEMISTRY

NAD+-Dependent DNA Ligase: A novel target waiting for the right inhibitor

(2007) Namrata Dwivedi et al.   MEDICINAL RESEARCH REVIEWS