Novel Insights into the Role of HDL-Associated Sphingosine-1-Phosphate in Cardiometabolic Diseases

Sphingosine-1-phosphate attenuates hypoxia/reoxygenation-induced cardiomyocyte injury via a mitochondrial pathway

(2019) Mengran Ke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signalling in macrophages

(2019) Mithila Vaidya et al.   JOURNAL OF LIPID RESEARCH

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

The Role of S1P and the Related Signaling Pathway in the Development of Tissue Fibrosis

(2019) Erjin Wang et al.   Frontiers in Pharmacology

Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity

(2018) Makoto Kurano et al.   BIOCHEMICAL JOURNAL

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study

(2018) Rozenn N. Lemaitre et al.   DIABETES

Visceral fat accumulation is associated with increased plasma sphingosine-1-phosphate levels in type 2 diabetes mellitus

(2018) Sayuri Tanaka et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Sphingosine 1-Phosphate and Atherosclerosis

(2018) Makoto Kurano et al.   Journal of Atherosclerosis and Thrombosis

Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF)

(2018) Gaurang P. Deshpande et al.   LIFE SCIENCES

Type 2 diabetes is associated with loss of HDL endothelium protective functions

(2018) Tomáš Vaisar et al.   PLoS One

Absence of Myocardial Fibrosis Predicts Favorable Long-Term Survival in New-Onset Heart Failure

(2018) Ankur Gulati et al.   Circulation-Cardiovascular Imaging

Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy

(2018) Petra Keul et al.   FASEB JOURNAL

Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R−/−) Mice

(2018) Renata Feuerborn et al.   THROMBOSIS AND HAEMOSTASIS

Dihydro-sphingosine 1-phosphate interacts with carrier proteins in a manner distinct from that of sphingosine 1-phosphate

(2018) Yuko Mishima et al.   BIOSCIENCE REPORTS

ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma

(2018) Jahangir Iqbal et al.   JOURNAL OF LIPID RESEARCH

Sphingosine 1-phosphate promotes mesenchymal stem cell-mediated cardioprotection against myocardial infarction via ERK1/2-MMP-9 and Akt signaling axis

(2018) Ruirui Chen et al.   LIFE SCIENCES

Circulating sphingolipids, fasting glucose, and impaired fasting glucose: The Strong Heart Family Study

(2018) Paul N. Jensen et al.   EBioMedicine

Combination of Plasma Biomarkers and Clinical Data for the Detection of Myocardial Fibrosis or Aggravation of Heart Failure Symptoms in Heart Failure with Preserved Ejection Fraction Patients

(2018) Cho-Kai Wu et al.   Journal of Clinical Medicine

Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2

(2017) Hui Yan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice

(2017) Leticia Gonzalez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate

(2017) Laurence Perségol et al.   JOURNAL OF LIPID RESEARCH

Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease

(2017) Amin Polzin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs

(2017) Kun Ren et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium

(2017) Mario Ruiz et al.   Lipids in Health and Disease

Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease

(2017) Rai Ajit K. Srivastava   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System

(2017) Alessandro Cannavo et al.   Frontiers in Pharmacology

Sphingosine 1-Phosphate Receptors: Do They Have a Therapeutic Potential in Cardiac Fibrosis?

(2017) Ambra Vestri et al.   Frontiers in Pharmacology

Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation

(2017) Naseer Ahmed et al.   Frontiers in Pharmacology

Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

(2017) Sei-ichiro Ohkura et al.   PLoS One

Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes

(2017) Pernille M. Christensen et al.   Scientific Reports

Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction

(2016) Fuyang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell ProtectionSignificance

(2016) Jonas W. Brinck et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ

(2016) Jinbiao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Impact of diabetes on the predictive value of heart failure biomarkers

(2016) Nuria Alonso et al.   Cardiovascular Diabetology

Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases

(2016) Mohamad Adada et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

(2016) Reijo Laaksonen et al.   EUROPEAN HEART JOURNAL

Role of JAK-STAT pathway in reducing cardiomyocytes hypoxia/reoxygenation injury induced by S1P postconditioning

(2016) Yuqing Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization

(2016) Mi-Hye Lee et al.   JOURNAL OF LIPID RESEARCH

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of hyperlipidaemia on plasma apolipoprotein M levels in patients with type 2 diabetes mellitus: an independent case–control study

(2016) Puhong Zhang et al.   Lipids in Health and Disease

Effect of sphingosine-1-phosphate on L-type calcium current and Ca2+ transient in rat ventricular myocytes

(2016) Emmanuel Eroume-A Egom et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling

(2016) Wee Siong Chew et al.   PHARMACOLOGICAL RESEARCH

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease

(2016) Nurgul Aytan et al.   Scientific Reports

Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+Sensitivity and Na+/H+Exchange and Mediates Protection by Ischemic Preconditioning

(2016) Petra Keul et al.   Journal of the American Heart Association

The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo

(2015) Wan-Yu Li et al.   ARCHIVES OF VIROLOGY

Autophagy and mitophagy in diabetic cardiomyopathy

(2015) Satoru Kobayashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis

(2015) Xiao-Dong Jing et al.   CLINICA CHIMICA ACTA

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis

(2015) Kate A. Parham et al.   FASEB JOURNAL

Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide

(2015) Jahangir Iqbal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

Sources, metabolism, and regulation of circulating sphingosine-1-phosphate

(2015) Monika Książek et al.   JOURNAL OF LIPID RESEARCH

Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content

(2015) Katherine Sattler et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HDL-S1P: cardiovascular functions, disease-associated alterations, and therapeutic applications

(2015) Bodo Levkau   Frontiers in Pharmacology

Improving Reconstituted HDL Composition for Efficient Post-Ischemic Reduction of Ischemia Reperfusion Injury

(2015) Marie-Claude Brulhart-Meynet et al.   PLoS One

Cardiac and vascular effects of fingolimod: Mechanistic basis and clinical implications

(2014) John Camm et al.   AMERICAN HEART JOURNAL

The role of sphingosine-1-phosphate in endothelial barrier function

(2014) Brent A. Wilkerson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

(2014) Xunliang Tong et al.   Cardiovascular Diabetology

Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P)

(2014) F. Poti et al.   CARDIOVASCULAR RESEARCH

HDL-Bound Sphingosine 1-Phosphate (S1P) Predicts the Severity of Coronary Artery Atherosclerosis

(2014) Katherine Sattler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingosine 1-Phosphate in Blood: Function, Metabolism, and Fate

(2014) Andreas V. Thuy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingosine-1-Phosphate as a Potential Target for the Treatment of Myocardial Infarction

(2014) Christian Waeber et al.   CIRCULATION JOURNAL

Molecular mechanisms of diabetic cardiomyopathy

(2014) Heiko Bugger et al.   DIABETOLOGIA

Systemic distribution, subcellular localization and differential expression of sphingosine-1-phosphate receptors in benign and malignant human tissues

(2014) Chunyi Wang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Rosiglitazone Enhances Apolipoprotein M (Apom) Expression in Rat's Liver

(2014) Guanghua Luo et al.   International Journal of Medical Sciences

Induction of Scavenger Receptor Class B Type I Is Critical for Simvastatin Enhancement of High-Density Lipoprotein-Induced Anti-Inflammatory Actions in Endothelial Cells

(2014) T. Kimura et al.   JOURNAL OF IMMUNOLOGY

Adiponectin regulates SR Ca2+ cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice

(2014) Wenjun Yan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inflammation and Chronic Heart Failure: From Biomarkers to Novel Anti-inflammatory Therapeutic Strategies

(2014) Georgios Bouras et al.   Medicinal Chemistry

Sphingosine Kinase 1 and Sphingosine-1-Phosphate in Oxidative Stress Evoked by 1-Methyl-4-Phenylpyridinium (MPP+) in Human Dopaminergic Neuronal Cells

(2014) Joanna Pyszko et al.   MOLECULAR NEUROBIOLOGY

Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication

(2014) Thorsten M. Leucker et al.   Frontiers in Physiology

First-dose effects of fingolimod: Pooled safety data from three phase 3 studies

(2014) John P. DiMarco et al.   Multiple Sclerosis and Related Disorders

Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding

(2013) Ye Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M

(2013) Makoto Kurano et al.   ATHEROSCLEROSIS

Apolipoprotein M promotes mobilization of cellular cholesterol in vivo

(2013) Sara Elsøe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy and mitophagy in the myocardium: therapeutic potential and concerns

(2013) Rebecca E Jimenez et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate

(2013) Xunliang Tong et al.   Cardiovascular Diabetology

β 1 -Adrenergic Receptor and Sphingosine-1-Phosphate Receptor 1 (S1PR1) Reciprocal Downregulation Influences Cardiac Hypertrophic Response and Progression to Heart Failure

(2013) Alessandro Cannavo et al.   CIRCULATION

Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes

(2013) Shiori Ito et al.   CORONARY ARTERY DISEASE

Apolipoprotein M

(2013) Christina Christoffersen et al.   CURRENT OPINION IN LIPIDOLOGY

Animal models of insulin resistance and heart failure

(2013) Mauricio Velez et al.   HEART FAILURE REVIEWS

The Apolipoprotein M–Sphingosine-1-Phosphate Axis: Biological Relevance in Lipoprotein Metabolism, Lipid Disorders and Atherosclerosis

(2013) Bas Arkensteijn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic Apolipoprotein M (ApoM) Overexpression Stimulates Formation of Larger ApoM/Sphingosine 1-Phosphate-enriched Plasma High Density Lipoprotein

(2013) Mingxia Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the complexities of the HDL lipidome

(2013) Anatol Kontush et al.   JOURNAL OF LIPID RESEARCH

Phospholipid Transfer Protein Deficiency Decreases the Content of S1P in HDL via the Loss of its Transfer Capability

(2013) Yang Yu et al.   LIPIDS

Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi

(2013) Giovanni D’Angelo et al.   NATURE

Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice

(2013) Martine Bot et al.   PLoS One

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis

(2013) Anthony O. Awojoodu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress

(2012) Joel S. Karliner   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells

(2012) A Koch et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Novel Biological Functions of High-Density Lipoprotein Cholesterol

(2012) Chieko Mineo et al.   CIRCULATION RESEARCH

Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

(2012) C. He et al.   DIABETES

Diabetic cardiomyopathy and diastolic heart failure – Difficulties with relaxation

(2012) C. Teupe et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

(2012) Masayuki Nagahashi et al.   FASEB JOURNAL

Mrp1 is Essential for Sphingolipid Signaling to P-Glycoprotein in Mouse Blood–Brain and Blood–Spinal Cord Barriers

(2012) Tara A Cartwright et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells

(2012) Yu Hisano et al.   PLoS One

FTY720 Protects Cardiac Microvessels of Diabetes: A Critical Role of S1P1/3 in Diabetic Heart Disease

(2012) Zhiyong Yin et al.   PLoS One

Sphingosine 1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P2 Receptor Subtype

(2012) Lukasz Japtok et al.   PLoS One

Sphingolipids, Lipotoxic Cardiomyopathy, and Cardiac Failure

(2012) Tae-Sik Park et al.   Heart Failure Clinics

Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy

(2012) Frank Spillmann et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Plasma levels of sphingosine-1-phosphate and apolipoprotein M in patients with monogenic disorders of HDL metabolism

(2011) Ratna Karuna et al.   ATHEROSCLEROSIS

Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

(2011) Sara Elsøe et al.   ATHEROSCLEROSIS

Pitavastatin: Novel effects on lipid parameters

(2011) M. John Chapman   ATHEROSCLEROSIS SUPPLEMENTS

AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

(2011) Zhonglin Xie et al.   Autophagy

Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions

(2011) Samy Selim et al.   CLINICAL SCIENCE

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests

(2011) Irène Oudejans et al.   EUROPEAN JOURNAL OF HEART FAILURE

A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression

(2011) Shuo Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

New Targets to Treat the Structural Remodeling of the Myocardium

(2011) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease

(2011) Kelley M Argraves et al.   Lipids in Health and Disease

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

(2011) C. Christoffersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Biological activities of HDL subpopulations and their relevance to cardiovascular disease

(2011) Laurent Camont et al.   TRENDS IN MOLECULAR MEDICINE

Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules

(2010) Gengqian Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

(2010) Athanasia Skoura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease

(2010) Katherine J. E. Sattler et al.   BASIC RESEARCH IN CARDIOLOGY

Microvascular fluid exchange and the revised Starling principle

(2010) J. Rodney Levick et al.   CARDIOVASCULAR RESEARCH

Opposing Effects of Apolipoprotein M on Catabolism of Apolipoprotein B–Containing Lipoproteins and Atherosclerosis

(2010) Christina Christoffersen et al.   CIRCULATION RESEARCH

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

(2010) Kazuaki Takabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

(2010) Yu Hisano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate

(2010) Constantin Bode et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The origin of fibroblasts and mechanism of cardiac fibrosis

(2010) Guido Krenning et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Blood sphingolipidomics in healthy humans: impact of sample collection methodology

(2010) Samar M. Hammad et al.   JOURNAL OF LIPID RESEARCH

Circulating sphingolipid biomarkers in models of type 1 diabetes

(2010) Todd E. Fox et al.   JOURNAL OF LIPID RESEARCH

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy

(2010) Carolyn Y. Ho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in Diastolic Dysfunction in Diabetes Mellitus Over Time

(2009) Aaron M. From et al.   AMERICAN JOURNAL OF CARDIOLOGY

Sphingosine-1-Phosphate Receptor-2 Regulates Expression of Smooth Muscle Alpha-Actin After Arterial Injury

(2009) Allison D. Grabski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters

(2009) W. Sean Davidson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The S1P2 receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes

(2009) Voahanginirina Randriamboavonjy et al.   BASIC RESEARCH IN CARDIOLOGY

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor- -stimulated collagen production by cardiac fibroblasts

(2009) N. Gellings Lowe et al.   CARDIOVASCULAR RESEARCH

Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection

(2009) K. Sattler et al.   CARDIOVASCULAR RESEARCH

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

(2009) Noriko Takuwa et al.   CARDIOVASCULAR RESEARCH

Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis

(2009) Miguel A. Frias et al.   CARDIOVASCULAR RESEARCH

Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion

(2009) Carlos A. Valverde et al.   CARDIOVASCULAR RESEARCH

Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness

(2009) Robin P.F. Dullaart et al.   CLINICA CHIMICA ACTA

Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart

(2009) Stephan E. Lehnart et al.   HEART FAILURE REVIEWS

Regulation of macrophage function by sphingosine-1-phosphate

(2009) Andreas Weigert et al.   IMMUNOBIOLOGY

Characterization of the ATP-dependent Sphingosine 1-Phosphate Transporter in Rat Erythrocytes

(2009) Naoki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection

(2009) Joel S Karliner   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Small, dense HDL3 particles attenuates apoptosis in endothelial cells: Pivotal role of apolipoprotein A-I

(2009) Juliana A. de Souza et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Serendipitous Fatty Acid Binding Reveals the Structural Determinants for Ligand Recognition in Apolipoprotein M

(2009) Madhumati Sevvana et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

ApoM: gene regulation and effects on HDL metabolism

(2009) Lars B. Nielsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

HDL-Associated Lysosphingolipids Inhibit NAD(P)H Oxidase-Dependent Monocyte Chemoattractant Protein-1 Production

(2008) Markus Tölle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sphingosine kinase regulation and cardioprotection

(2008) J. S. Karliner   CARDIOVASCULAR RESEARCH

Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate

(2008) A. I. Duenas et al.   CARDIOVASCULAR RESEARCH

Why is HDL functionally deficient in type 2 diabetes?

(2008) Anatol Kontush et al.   Current Diabetes Reports

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

(2008) Josefin Ahnström et al.   JOURNAL OF LIPID RESEARCH

Recycle or die: The role of autophagy in cardioprotection

(2008) Åsa B. Gustafsson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS

The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

(2008) A. Kawahara et al.   SCIENCE

Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins

(2007) J Igarashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-density lipoprotein, sphingosine 1-phosphate, and atherosclerosis

(2007) Jerzy-Roch Nofer   Journal of Clinical Lipidology