Nicastrin mutations in familial acne inversa impact keratinocyte proliferation and differentiation through the Notch and phosphoinositide 3-kinase/AKT signalling pathways

Phenotypic heterogeneity implies heterogeneous pathogenic pathways in hidradenitis suppurativa

(2015) John W. Frew et al.   EXPERIMENTAL DERMATOLOGY

Acne Inversa Caused by Missense Mutations in NCSTN Is Not Fully Compatible with Impairments in Notch Signaling

(2015) Xulun Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

γ-Secretase Mutation in an African American Family With Hidradenitis Suppurativa

(2015) Sean Chen et al.   JAMA Dermatology

A novel NCSTN mutation alone may be insufficient for the development of familial hidradenitis suppurativa

(2014) Yukiko Nomura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Crystal structure of the γ-secretase component nicastrin

(2014) Tian Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting response to anti-TNF-alpha treatment in Hidradenitis suppurativa

(2013) G.B.E. Jemec   BRITISH JOURNAL OF DERMATOLOGY

Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology

(2013) Bodo C. Melnik et al.   EXPERIMENTAL DERMATOLOGY

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

(2013) Utpal B Pajvani et al.   NATURE MEDICINE

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes

(2013) Yi Li et al.   STRUCTURE

Impaired Notch signalling: the unifying mechanism explaining the pathogenesis of hidradenitis suppurativa (acne inversa)

(2012) B.C. Melnik et al.   BRITISH JOURNAL OF DERMATOLOGY

Mutations in the γ-Secretase Genes NCSTN , PSENEN , and PSEN1 Underlie Rare Forms of Hidradenitis Suppurativa (Acne Inversa)

(2012) Andrew E. Pink et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

γ-Secretase Mutations in Hidradenitis Suppurativa: New Insights into Disease Pathogenesis

(2012) Andrew E. Pink et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of Three Hidradenitis Suppurativa Phenotypes: Latent Class Analysis of a Cross-Sectional Study

(2012) Florence Canoui-Poitrine et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Two novel mutations of the NCSTN gene in Chinese familial acne inverse

(2012) C. Zhang et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Two novel mutations of the nicastrin gene in Chinese patients with acne inversa

(2011) C.-R. Li et al.   BRITISH JOURNAL OF DERMATOLOGY

Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae

(2010) M. von Laffert et al.   BRITISH JOURNAL OF DERMATOLOGY

 -Secretase Gene Mutations in Familial Acne Inversa

(2010) B. Wang et al.   SCIENCE

Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells

(2009) O. Meurette et al.   CANCER RESEARCH

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

(2009) C. Lavogiez et al.   DERMATOLOGY

Epidermal Notch signalling: differentiation, cancer and adhesion

(2008) Fiona M Watt et al.   CURRENT OPINION IN CELL BIOLOGY