Insights into the study and origin of the citrullinome in rheumatoid arthritis

Mapping Citrullinated Sites in Multiple Organs of Mice Using Hypercitrullinated Library

(2019) Justyna Fert-Bober et al.   JOURNAL OF PROTEOME RESEARCH

The structure, specificity and function of anti-citrullinated protein antibodies

(2019) Changrong Ge et al.   Nature Reviews Rheumatology

Individuals at risk of seropositive rheumatoid arthritis‐ the evolving story

(2019) Solbritt Rantapää Dahlqvist et al.   JOURNAL OF INTERNAL MEDICINE

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

(2019) Eduardo Gómez-Bañuelos et al.   Journal of Clinical Medicine

Qualitative, quantitative and genotypic evaluation of Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum isolated from individuals with different periodontal clinical conditions

(2018) Viviane Aparecida Arenas Rodrigues et al.   ANAEROBE

Pitfalls in the detection of citrullination and carbamylation

(2018) M.K. Verheul et al.   AUTOIMMUNITY REVIEWS

Rheumatoid arthritis and citrullination

(2018) Erika Darrah et al.   CURRENT OPINION IN RHEUMATOLOGY

SWATH mass spectrometry as a tool for quantitative profiling of the matrisome

(2018) Lukas Krasny et al.   Journal of Proteomics

Mining the Human Tissue Proteome for Protein Citrullination

(2018) Chien-Yun Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Mapping the tandem mass spectrometric characteristics of citrulline-containing peptides

(2018) Arnold Steckel et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis

(2018) M. Kristen Demoruelle et al.   Arthritis & Rheumatology

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation

(2018) Elmar Pieterse et al.   ANNALS OF THE RHEUMATIC DISEASES

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

(2018) V. Michael Holers et al.   Nature Reviews Rheumatology

Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis

(2018) Erika Darrah et al.   Frontiers in Immunology

Validation of an enzyme-linked immunosorbent assay for the quantification of citrullinated histone H3 as a marker for neutrophil extracellular traps in human plasma

(2017) Charlotte Thålin et al.   IMMUNOLOGIC RESEARCH

The case for periodontitis in the pathogenesis of rheumatoid arthritis

(2017) Jan Potempa et al.   Nature Reviews Rheumatology

The role of autoantibodies in the pathophysiology of rheumatoid arthritis

(2017) V. F. A. M. Derksen et al.   Seminars in Immunopathology

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Association of Distinct Fine Specificities of Anti−Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis

(2017) Anja Schwenzer et al.   Arthritis & Rheumatology

Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients

(2017) M. Kristen Demoruelle et al.   Arthritis & Rheumatology

Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils

(2017) Yebin Zhou et al.   Frontiers in Immunology

Age-related prevalence and characteristics of Aggregatibacter actinomycetemcomitans in periodontitis patients living in Sweden

(2017) Rolf Claesson et al.   Journal of Oral Microbiology

Antibodies to native and citrullinated RA33 (hnRNP A2/B1) challenge citrullination as the inciting principle underlying loss of tolerance in rheumatoid arthritis

(2016) Maximilian F Konig et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF

(2016) Fei Wang et al.   CLINICAL RHEUMATOLOGY

Arginine selective reagents for ligation to peptides and proteins

(2016) Darren A. Thompson et al.   JOURNAL OF PEPTIDE SCIENCE

Proteome Analysis of Rheumatoid Arthritis Gut Mucosa

(2016) Tue Bjerg Bennike et al.   JOURNAL OF PROTEOME RESEARCH

Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

(2016) Erika Darrah et al.   JOURNAL OF PROTEOME RESEARCH

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

SWATH Mass Spectrometry Performance Using Extended Peptide MS/MS Assay Libraries

(2016) Jemma X. Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis

(2016) M. F. Konig et al.   Science Translational Medicine

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

(2016) Maximilian F. Konig et al.   Frontiers in Immunology

Current Challenges and Limitations in Antibody-Based Detection of Citrullinated Histones

(2016) Indira Neeli et al.   Frontiers in Immunology

Crystal structure ofPorphyromonas gingivalispeptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis

(2015) Anna B Montgomery et al.   ANNALS OF THE RHEUMATIC DISEASES

Aggregatibacter actinomycetemcomitans serotypes and DGGE subtypes in Thai adults with chronic periodontitis

(2015) Nuntiya Pahumunto et al.   ARCHIVES OF ORAL BIOLOGY

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

(2015) Elena B Lugli et al.   ARTHRITIS RESEARCH & THERAPY

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase

(2015) Theodoros Goulas et al.   Scientific Reports

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

(2015) Julia Spengler et al.   Arthritis & Rheumatology

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation

(2014) A Jimmy Ytterberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Characterization and serotype distribution of Aggregatibacter actinomycetemcomitans isolated from a population of periodontitis patients in Spain

(2014) María Mínguez et al.   ARCHIVES OF ORAL BIOLOGY

Assessing the Citrullinome in Rheumatoid Arthritis Synovial Fluid with and without Enrichment of Citrullinated Peptides

(2014) Astrid E. V. Tutturen et al.   JOURNAL OF PROTEOME RESEARCH

Association of Cross-Reactive Antibodies Targeting Peptidyl-Arginine Deiminase 3 and 4 with Rheumatoid Arthritis-Associated Interstitial Lung Disease

(2014) Jon T. Giles et al.   PLoS One

Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

(2014) Neville Gully et al.   PLoS One

Leukotoxic Activity of Aggregatibacter actinomycetemcomitans and Periodontal Attachment Loss

(2014) Carola Höglund Åberg et al.   PLoS One

Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

(2014) Dres Damgaard et al.   ARTHRITIS RESEARCH & THERAPY

Reply

(2014) Miriam A. Shelef et al.   Arthritis & Rheumatology

Insights Into the Significance of Peptidylarginine Deiminase 4 and Antibodies Against Citrullinated Antigens in the Absence of “True ACPAs” in an Experimental Model of Arthritis: Comment on the Article by Shelef et al

(2014) Maximilian F. Konig et al.   Arthritis & Rheumatology

Matrix-assisted laser desorption ionization–time of flight mass spectrometry identification of peptide citrullination site using Br signature

(2013) Mikyung Choi et al.   ANALYTICAL BIOCHEMISTRY

Identification of Citrullinated Hsp90 Isoforms as Novel Autoantigens in Rheumatoid Arthritis-Associated Interstitial Lung Disease

(2013) Lisa Harlow et al.   ARTHRITIS AND RHEUMATISM

Sputa autoantibodies in patients with established rheumatoid arthritis and subjects at-risk for future clinically apparent disease

(2013) Van C. Willis et al.   ARTHRITIS AND RHEUMATISM

Methods for the Detection of Peptidylarginine Deiminase (PAD) Activity and Protein Citrullination

(2013) Sanne M. M. Hensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification and characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation

(2013) Zhicheng Jin et al.   PROTEOMICS

Erosive Rheumatoid Arthritis Is Associated with Antibodies That Activate PAD4 by Increasing Calcium Sensitivity

(2013) E. Darrah et al.   Science Translational Medicine

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

(2013) V. Romero et al.   Science Translational Medicine

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Structural Changes and Antibody Enrichment in the Lungs Are Early Features of Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis

(2013) Gudrun Reynisdottir et al.   Arthritis & Rheumatology

Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the ‘AMC-Senshu’ method

(2012) Jing Shi et al.   ANNALS OF THE RHEUMATIC DISEASES

The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin

(2012) Joyce J. B. C. van Beers et al.   ARTHRITIS AND RHEUMATISM

Presence and Role of Anti-Citrullinated Protein Antibodies in Experimental Arthritis Models

(2012) Tineke Cantaert et al.   ARTHRITIS AND RHEUMATISM

Seeing Citrulline: Development of a Phenylglyoxal-Based Probe To Visualize Protein Citrullination

(2012) Kevin L. Bicker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Next-generation proteomics: towards an integrative view of proteome dynamics

(2012) A. F. Maarten Altelaar et al.   NATURE REVIEWS GENETICS

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

(2012) Jeremy Sokolove et al.   PLoS One

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles

(2012) Joyce JBC van Beers et al.   ARTHRITIS RESEARCH & THERAPY

In memoriam Enno Mandema, MD (1921-2010)

(2011) Bouke P. Hazenberg et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

(2011) Erika Darrah et al.   ANNALS OF THE RHEUMATIC DISEASES

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

Inflammation-Associated Autophagy-Related Programmed Necrotic Death of Human Neutrophils Characterized by Organelle Fusion Events

(2011) C. C. Mihalache et al.   JOURNAL OF IMMUNOLOGY

Effectiveness of CID, HCD, and ETD with FT MS/MS for Degradomic-Peptidomic Analysis: Comparison of Peptide Identification Methods

(2011) Yufeng Shen et al.   JOURNAL OF PROTEOME RESEARCH

Natural Killer-22 Cells in the Synovial Fluid of Patients with Rheumatoid Arthritis Are an Innate Source of Interleukin 22 and Tumor Necrosis Factor-α

(2011) JIE REN et al.   JOURNAL OF RHEUMATOLOGY

The microbiome and rheumatoid arthritis

(2011) Jose U. Scher et al.   Nature Reviews Rheumatology

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage

(2011) J. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response

(2011) Anders Johansson   Toxins

On-line liquid chromatography neutral loss-triggered electron transfer dissociationmass spectrometry for the targeted analysis of citrullinated peptides

(2010) Andrew J. Creese et al.   Analytical Methods

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The complete microspeciation of arginine and citrulline

(2010) Gábor Orgován et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Occurrence of Aggregatibacter actinomycetemcomitans serotypes in subgingival plaque from United States subjects

(2010) C. Chen et al.   Molecular Oral Microbiology

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Mass spectrometric analysis of rheumatoid arthritic synovial tissue identifies specific citrullination sites on fibrinogen

(2010) Monika Hermansson et al.   Proteomics Clinical Applications

Effect of citrullination on the function and conformation of antithrombin

(2009) A. Ordóñez et al.   FEBS Journal

Serotypes of Aggregatibacter actinomycetemcomitans in Patients With Different Ethnic Backgrounds

(2009) Ti-Sun Kim et al.   JOURNAL OF PERIODONTOLOGY

Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry

(2009) Maria Stensland et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes

(2009) Vincent Goëb et al.   ARTHRITIS RESEARCH & THERAPY

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis

(2008) Michelle L. Harris et al.   ARTHRITIS AND RHEUMATISM

Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis

(2008) Andrew Kinloch et al.   ARTHRITIS AND RHEUMATISM

Identification of multiple post-translational modifications in the porcine brain specific p25

(2008) Anne J. Kleinnijenhuis et al.   JOURNAL OF NEUROCHEMISTRY

Neutral loss of isocyanic acid in peptide CID spectra: A novel diagnostic marker for mass spectrometric identification of protein citrullination

(2008) Gang Hao et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Non-apoptotic functions of granzymes

(2008) V. Romero et al.   TISSUE ANTIGENS

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

(2008) Xiaoyan Zhao et al.   ARTHRITIS RESEARCH & THERAPY

Redox Regulation in the Extracellular Environment

(2007) Filomena G. Ottaviano et al.   CIRCULATION JOURNAL