Journal
JOURNAL OF CLINICAL MEDICINE
Volume 8, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jcm8091309
Keywords
Rheumatoid arthritis; Porphyromonas gingivalis; Aggregatibacter actinomycetemcomitans; periodontitis; periodontal disease; citrullination; peptidylarginine deiminase; ACPA; anti-CCP
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Funding
- Jerome L. Greene Foundation
- Rheumatology Research Foundation
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National Institutes of Health (NIH) [R01 AR069569]
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Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by immune-mediated damage of synovial joints and antibodies to citrullinated antigens. Periodontal disease, a bacterial-induced inflammatory disease of the periodontium, is commonly observed in RA and has implicated periodontal pathogens as potential triggers of the disease. In particular, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have gained interest as microbial candidates involved in RA pathogenesis by inducing the production of citrullinated antigens. Here, we will discuss the clinical and mechanistic evidence surrounding the role of these periodontal bacteria in RA pathogenesis, which highlights a key area for the treatment and preventive interventions in RA.
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