Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 54, Issue 5, Pages 965-971Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2010.11.023
Keywords
Arginine; Citrulline; Microspeciation; Microscopic acid-base properties; Highly basic media
Categories
Funding
- OTKA [T 73804]
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H-1 NMR-pH titrations of arginine, the most basic natural amino acid and citrulline, its neutral counterpart were carried out. Two other closely related auxiliary compounds were also studied. The 8 macroscopic protonation constants were determined. Combining the four datasets in a deductive method, all the 12 microconstants of arginine, the 4 microconstants of citrulline and arginine amide were calculated. An error-propagation analysis and the pH-dependent distribution of the 8 arginine microspecies are provided. (C) 2010 Elsevier B.V. All rights reserved.
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