Review
Biochemistry & Molecular Biology
Joaquin Abelli, Gabriel Mendez-Valdes, Francisca Gomez-Hevia, Maria Chiara Bragato, Silvia Chichiarelli, Luciano Saso, Ramon Rodrigo
Summary: Septic shock is a major cause of mortality in critical patient units, with an increasing incidence in recent years. Oxidative stress plays a crucial role in the pathogenesis of sepsis. Despite numerous studies, effective therapies to reduce morbidity and mortality associated with septic shock have not been developed. However, interventions with certain antioxidant compounds may have a positive effect. Further studies are required to demonstrate the efficacy of these therapies.
Review
Toxicology
Marta Justyna Koziel, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: Nrf2 is a crucial transcription factor involved in cellular response to oxidative stress, regulating the expression of antioxidant enzymes to remove free radicals. Its increased expression in cancer cells suggests its tissue-specific role. Additionally, Nrf2 may play an important role in response to environmental factors such as mycotoxins.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Clinical Neurology
Saif Ahmad, Seth Truran, Nina Karamanova, Adam Kindelin, Maria Lozoya, Volkmar Weissig, Hannah Emerson, Daniel R. Griffiths, Tyler Vail, Jonathan Lifshitz, Andrew F. Ducruet, Raymond Q. Migrino
Summary: The study found that nanoliposomes can induce an antioxidant protective response in cells, protecting neuronal cells and reducing stroke injury in mice. Nanoliposomes may be a novel agent for the treatment of stroke.
Article
Biochemistry & Molecular Biology
Vincenza Valerio, Gizem Keceli, Donato Moschetta, Benedetta Porro, Michele Ciccarelli, Ilaria Massaiu, Paola Songia, Angela S. Maione, Valentina Alfieri, Veronika A. Myasoedova, Marco Zanobini, Nazareno Paolocci, Paolo Poggio
Summary: This study investigates the role of oxidative stress and endothelial dysfunction in the progression of calcific aortic valve stenosis (CAVS). The results indicate that oxidation-induced protein S-glutathionylation (P-SSG) contributes to the phenotypic switch in human aortic valvular tissue, leading to calcium deposition. The use of antioxidants can prevent these alterations.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Medicinal
Yinyan Yin, Nuo Xu, Tao Qin, Bangyue Zhou, Yi Shi, Xinyi Zhao, Bixia Ma, Zhengzhong Xu, Chunmei Li
Summary: The study showed that astaxanthin exhibits strong antioxidant properties by increasing cellular reductive status, upregulating antioxidant enzyme activities, and inhibiting cytokine secretions, which could potentially alleviate DC-related inflammatory responses and serve as a promising approach for sepsis treatment.
Article
Pharmacology & Pharmacy
Veronica F. Salau, Ochuko L. Erukainure, Kolawole A. Olofinsan, Recardia L. S. Schoeman, Motlalepula G. Matsabisa
Summary: The study investigated the hepatoprotective effect of Lippia javanica herbal tea in Fe2+-mediated hepatic oxidative injury. Results showed that the infusion has strong antioxidant activity and hepatoprotective effects. It increased the levels of reduced glutathione, non-protein thiol, superoxide dismutase, and catalase, while reducing hepatic malondialdehyde levels and several enzyme activities. The infusion contains phytoconstituents such as phenolic compounds, tannins, phenolic glycosides, and terpenoids. Molecular docking analysis revealed the potential binding affinity of dihydroroseoside and obacunone with antioxidant enzymes. Overall, the study highlights the potential therapeutic use of L. javanica herbal tea in oxidative stress-related liver diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Filomena Mottola, Renata Finelli, Concetta Iovine, Maria Carannante, Marianna Santonastaso, Lucia Rocco
Summary: The study revealed that ellagic acid and curcumin can protect zebrafish blood cells from DNA damage and apoptosis. Co-incubation of antioxidants with benzene significantly improved the cell parameters compared to cells treated with benzene alone.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Kirinde Gedara Isuru Sandanuwan Kirindage, Ilekuttige Priyan Shanura Fernando, Arachchige Maheshika Kumari Jayasinghe, Eui-Jeong Han, Mawalle Kankanamge Hasitha Madhawa Dias, Kyung-Pil Kang, Sung-Ig Moon, Tai-Sun Shin, Ayeong Ma, Ginnae Ahn
Summary: The present study identified phenolic compounds in Moringa oleifera hot water extract (MOH) and evaluated its antioxidant activity on H2O2-induced oxidative stress in Vero cells. Results showed that MOH exhibited strong radical scavenging and antioxidant properties, reduced ROS generation, increased cell viability, suppressed mitochondrial depolarization and apoptosis, and activated the Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Bastiaan S. Star, Elisabeth C. van der Slikke, Azuwerus van Buiten, Robert H. Henning, Hjalmar R. Bouma
Summary: This study explores the efficacy of a novel mitochondrial protective compound, SUL-138, in sepsis models. The results show that SUL-138 protects mitochondrial function, improves survival rate, mitigates systemic inflammation, and preserves kidney function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Javier Toro-Perez, Ramon Rodrigo
Summary: Surgical complications following procedures have been studied for years, with oxidative stress playing a crucial role. The use of antioxidants is important in preventing and mitigating the damage caused by oxidative stress.
Article
Biochemistry & Molecular Biology
Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Xavier Capo, David Mateos, Lucia Ugarriza, Josep A. Tur, Antoni Sureda
Summary: The study found that inflammatory biomarkers increased in the plasma and PBMCs of obese patients, while antioxidant enzyme activities also increased with BMI, providing useful biomarkers for monitoring the progression and reversal of obesity.
Article
Biochemistry & Molecular Biology
Souha Hammouda, Imen Ghzaiel, Pol Picon-Pages, Wiem Meddeb, Wided Khamlaoui, Sonia Hammami, Francisco J. Munoz, Mohamed Hammami, Amira Zarrouk
Summary: Oxysterols, particularly 7 beta-hydroxycholesterol (7 beta-OHC), are implicated in neurodegenerative diseases. This study showed that 7 beta-OHC induced oxidative stress and apoptosis in human neuroblastoma cells, but pre-treatment with Nigella sativa and Milk thistle seed oils could attenuate the damages caused by 7 beta-OHC.
Article
Nutrition & Dietetics
Huong Thi Lan Nguyen, Stefan Kasapis, Nitin Mantri
Summary: The study compared the effects of Manuka honey and newly developed honeys on oxidative stress and cholesterol homeostasis, showing that Arjuna, Guggul, and Manuka honeys had significant antioxidant activities and reduced total cholesterol levels, while Jiaogulan honey exhibited the most cytotoxic effects.
Article
Anesthesiology
K. Mertens, D. A. Lowes, N. R. Webster, J. Talib, L. Hall, M. J. Davies, J. H. Beattie, H. F. Galley
BRITISH JOURNAL OF ANAESTHESIA
(2015)
Article
Anesthesiology
B. McCormick, D. A. Lowes, L. Colvin, C. Torsney, H. F. Galley
BRITISH JOURNAL OF ANAESTHESIA
(2016)
Article
Endocrinology & Metabolism
Helen F. Galley, Barry McCormick, Kirsten L. Wilson, Damon A. Lowes, Lesley Colvin, Carole Torsney
JOURNAL OF PINEAL RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Damon A. Lowes, Helen F. Galley
BIOCHEMICAL JOURNAL
(2011)
Article
Anesthesiology
A. L. Hill, D. A. Lowes, N. R. Webster, C. C. Sheth, N. A. R. Gow, H. F. Galley
BRITISH JOURNAL OF ANAESTHESIA
(2009)
Article
Anesthesiology
D. A. Lowes, A. M. Almawash, N. R. Webster, V. L. Reid, H. F. Galley
BRITISH JOURNAL OF ANAESTHESIA
(2011)
Article
Anesthesiology
D. A. Lowes, N. R. Webster, M. P. Murphy, H. F. Galley
BRITISH JOURNAL OF ANAESTHESIA
(2013)
Article
Cell Biology
Helen F. Galley, Damon A. Lowes, Keith Thompson, Naomi D. Wilson, Carol A. Wallace, Nigel R. Webster
CELL BIOLOGY INTERNATIONAL
(2015)
Correction
Biochemistry & Molecular Biology
Damon A. Lowes, Bensita M. V. Thottakam, Nigel R. Webster, Michael P. Murphy, Helen F. Galley
FREE RADICAL BIOLOGY AND MEDICINE
(2009)
Article
Biochemistry & Molecular Biology
Damon A. Lowes, Carol Wallace, Michael P. Murphy, Nigel R. Webster, Helen F. Galley
FREE RADICAL RESEARCH
(2009)
Article
Biochemistry & Molecular Biology
Damon A. Lowes, Nigel R. Webster, Helen F. Galley
FREE RADICAL RESEARCH
(2010)
Article
Endocrinology & Metabolism
Helen F. Galley, Damon A. Lowes, Lee Allen, Gary Cameron, Lorna S. Aucott, Nigel R. Webster
JOURNAL OF PINEAL RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Beverley E. Minter, Damon A. Lowes, Nigel R. Webster, Helen F. Galley
Article
Behavioral Sciences
Damon A. Lowes, Helen F. Galley, Alessandro P. S. Moura, Nigel R. Webster
BEHAVIOURAL BRAIN RESEARCH
(2017)