Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Melatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model

(2013) Mahdi Alamili et al.   JOURNAL OF CRITICAL CARE

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

(2013) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis

(2012) Giovanni Li Volti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling

(2012) Dingbo Shi et al.   JOURNAL OF PINEAL RESEARCH

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Experimental Human Endotoxemia: A Model of the Systemic Inflammatory Response Syndrome?

(2012) Steve E. Calvano et al.   Surgical Infections

Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis

(2011) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Pharmacokinetics of orally administered melatonin in critically ill patients

(2010) Giovanni Mistraletti et al.   JOURNAL OF PINEAL RESEARCH

Antioxidant Therapy in Critically Septic Patients

(2009) S. Rinaldi et al.   CURRENT DRUG TARGETS

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats

(2008) Jeng-Yuan Wu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42

(2008) Juefei Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Pharmacokinetics in Premenopausal and Postmenopausal Healthy Female Volunteers

(2007) Sophia L. Markantonis et al.   JOURNAL OF CLINICAL PHARMACOLOGY