Female ageing affects the DNA repair capacity of oocytes in IVF using a controlled model of sperm DNA damage in mice

The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing

(2018) Amy L Winship et al.   HUMAN REPRODUCTION UPDATE

Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes

(2018) Jacinta H. Martin et al.   Scientific Reports

Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes

(2018) Tim Sanchez et al.   FERTILITY AND STERILITY

Corrigendum: Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos

(2017) Xinyi Wang et al.   GENOME RESEARCH

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries

(2016) Vijayakumar Govindaraj et al.   ANIMAL BIOTECHNOLOGY

DNA damage response during mouse oocyte maturation

(2016) Alexandra Mayer et al.   CELL CYCLE

Causes and consequences of oxidative stress in spermatozoa

(2016) Robert John Aitken et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo

(2015) Tessa Lord et al.   DEVELOPMENTAL BIOLOGY

Effect of sperm DNA fragmentation on the clinical outcomes for in vitro fertilization and intracytoplasmic sperm injection in women with different ovarian reserves

(2015) Jianyuan Jin et al.   FERTILITY AND STERILITY

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

(2015) Valentina Turinetto et al.   NUCLEIC ACIDS RESEARCH

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

The effect of sperm DNA fragmentation on the dynamics of the embryonic development in intracytoplasmatic sperm injection

(2015) Artur Wdowiak et al.   Reproductive Biology

Changes in the expression of DNA double strand break repair genes in primordial follicles from immature and aged rats

(2015) Vijayakumar Govindaraj et al.   REPRODUCTIVE BIOMEDICINE ONLINE

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

(2015) Petros Marangos et al.   Nature Communications

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

(2015) Josie K. Collins et al.   Nature Communications

Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair

(2015) Francesco Marchetti et al.   Scientific Reports

Different fates of oocytes with DNA double-strand breaksin vitroandin vivo

(2014) Fei Lin et al.   CELL CYCLE

Removal of annexin V–positive sperm cells for intracytoplasmic sperm injection in ovum donation cycles does not improve reproductive outcome: a controlled and randomized trial in unselected males

(2014) Laura Romany et al.   FERTILITY AND STERILITY

The effects of DNA double-strand breaks on mouse oocyte meiotic maturation

(2013) Jun-Yu Ma et al.   CELL CYCLE

The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1

(2013) T. B. Smith et al.   JOURNAL OF CELL SCIENCE

Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics

(2013) Alison Campbell et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans

(2013) S. Titus et al.   Science Translational Medicine

Molecular origin of female meiotic aneuploidies

(2012) Alan H. Handyside   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oocytes Progress beyond Prophase in the Presence of DNA Damage

(2012) Petros Marangos et al.   CURRENT BIOLOGY

The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis

(2012) L. Robinson et al.   HUMAN REPRODUCTION

Types, Causes, Detection and Repair of DNA Fragmentation in Animal and Human Sperm Cells

(2012) Clara González-Marín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib

(2012) Jeffrey B Kerr et al.   NATURE MEDICINE

DNA Double Strand Breaks but Not Interstrand Crosslinks Prevent Progress through Meiosis in Fully Grown Mouse Oocytes

(2012) Wai Shan Yuen et al.   PLoS One

The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion

(2012) J B Kerr et al.   REPRODUCTION

The Activation of DNA Damage Detection and Repair Responses in Cleavage-Stage Rat Embryos by a Damaged Paternal Genome

(2012) Lisanne Grenier et al.   TOXICOLOGICAL SCIENCES

Chromosome Abnormalities in the Human Oocyte

(2011) E. Fragouli et al.   CYTOGENETIC AND GENOME RESEARCH

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Apoptosis and DNA damage in human spermatozoa

(2010) R John Aitken et al.   ASIAN JOURNAL OF ANDROLOGY

Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis

(2010) Denny Sakkas et al.   FERTILITY AND STERILITY

Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality

(2010) Marcos Meseguer et al.   FERTILITY AND STERILITY

Gene expression profiles of single human mature oocytes in relation to age

(2010) M.L. Grøndahl et al.   HUMAN REPRODUCTION

Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

(2010) Loro L. Kujjo et al.   PLoS One

Involvement of Global Genome Repair, Transcription Coupled Repair, and Chromatin Remodeling in UV DNA Damage Response Changes during Development

(2010) Hannes Lans et al.   PLoS Genetics

Expression profiling of DNA repair genes in human oocytes and blastocysts using microarrays

(2009) Souraya Jaroudi et al.   HUMAN REPRODUCTION

Association of BRCA1 Mutations With Occult Primary Ovarian Insufficiency: A Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks

(2009) Kutluk Oktay et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation

(2008) Alwin Derijck et al.   HUMAN MOLECULAR GENETICS

Cellular and molecular aspects of ovarian follicle ageing

(2008) Carla Tatone et al.   HUMAN REPRODUCTION UPDATE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols