mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation

(2019) Murali Palangat et al.   GENES & DEVELOPMENT

An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response

(2018) Jae-Woong Chang et al.   NUCLEIC ACIDS RESEARCH

Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes

(2018) Hai Dang Nguyen et al.   CANCER RESEARCH

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

(2018) Dennis Liang Fei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes

(2017) Bon Ham Yip et al.   JOURNAL OF CLINICAL INVESTIGATION

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

Mechanistic insights into precursor messenger RNA splicing by the spliceosome

(2017) Yigong Shi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR-sensitive translation: Cleared fog reveals more trees

(2017) Laia Masvidal et al.   RNA Biology

Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures

(2017) Jermaine L. Jenkins et al.   TRENDS IN GENETICS

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

(2017) Cara Lunn Shirai et al.   Nature Communications

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression

(2016) R. M. Denton et al.   BIOCHEMICAL JOURNAL

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

(2016) Valentina Gandin et al.   GENOME RESEARCH

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3′ End Formation

(2016) Sung Mi Park et al.   MOLECULAR CELL

Alternative splicing ofU2AF1reveals a shared repression mechanism for duplicated exons

(2016) Jana Kralovicova et al.   NUCLEIC ACIDS RESEARCH

Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift

(2016) Lena Voith von Voithenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

(2015) Cara Lunn Shirai et al.   CANCER CELL

A novel 3′ splice site recognition by the two zinc fingers in the U2AF small subunit

(2015) Hisashi Yoshida et al.   GENES & DEVELOPMENT

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3′ splice-site organization and activity of U2AF-related proteins

(2015) Jana Kralovicova et al.   NUCLEIC ACIDS RESEARCH

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation

(2015) Jae-Woong Chang et al.   Nature Communications

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome

(2014) Changwei Shao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative splicing of mutually exclusive exons—A review

(2013) Martin Pohl et al.   BIOSYSTEMS

A guide to design and optimization of reporter assays for 3′ untranslated region mediated regulation of mammalian messenger RNAs

(2013) Jamie Van Etten et al.   METHODS

Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells

(2013) Sébastien Durand et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

hnRNP A1 Proofreads 3′ Splice Site Recognition by U2AF

(2012) Joao Paulo Tavanez et al.   MOLECULAR CELL

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

(2011) Takuya Shirakihara et al.   EMBO JOURNAL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Gemin5 Delivers snRNA Precursors to the SMN Complex for snRNP Biogenesis

(2010) Jeongsik Yong et al.   MOLECULAR CELL

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

(2009) Claude C. Warzecha et al.   MOLECULAR CELL

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs

(2009) Giorgio Grillo et al.   NUCLEIC ACIDS RESEARCH