Microglia in the hypothalamus respond to tumor‐derived factors and are protective against cachexia during pancreatic cancer

MyD88 signalling is critical in the development of pancreatic cancer cachexia

(2019) Xinxia Zhu et al.   Journal of Cachexia Sarcopenia and Muscle

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

(2019) Katherine A. Michaelis et al.   Nature Communications

TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia

(2018) Kevin G. Burfeind et al.   BRAIN BEHAVIOR AND IMMUNITY

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Chronic minocycline treatment reduces the anxiety-like behaviors induced by repeated restraint stress through modulating neuroinflammation

(2018) Liu Haiyan et al.   BRAIN RESEARCH BULLETIN

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

(2018) Cristina García-Cáceres et al.   NATURE NEUROSCIENCE

Hypothalamic Microglial Activation in Obesity: A Mini-Review

(2018) Natália F. Mendes et al.   Frontiers in Neuroscience

Establishment and characterization of a novel murine model of pancreatic cancer cachexia

(2017) Katherine A. Michaelis et al.   Journal of Cachexia Sarcopenia and Muscle

High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia

(2016) Caroline Baufeld et al.   ACTA NEUROPATHOLOGICA

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity

(2016) Thomas R. Flint et al.   Cell Metabolism

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The central role of hypothalamic inflammation in the acute illness response and cachexia

(2016) Kevin G. Burfeind et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Prevalence and clinical impact of cachexia in chronic illness in Europe, USA, and Japan: facts and numbers update 2016

(2016) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function

(2015) Diana M. Norden et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia

(2015) Alessio Molfino et al.   MEDIATORS OF INFLAMMATION

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

(2015) Kelly Foley et al.   Science Signaling

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

(2015) Kelly Foley et al.   Science Signaling

The regulation of muscle mass by endogenous glucocorticoids

(2015) Theodore P. Braun et al.   Frontiers in Physiology

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

KIT oncogene inhibition drives intratumoral macrophage M2 polarization

(2013) Michael J. Cavnar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglial control of neuronal activity

(2013) Catherine Béchade et al.   Frontiers in Cellular Neuroscience

Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

(2012) O. Cavel et al.   CANCER RESEARCH

Neural invasion induces cachexiaviaastrocytic activation of neural route in pancreatic cancer

(2012) Akira Imoto et al.   INTERNATIONAL JOURNAL OF CANCER

Brain conditioning is instrumental for successful microglia reconstitution following hematopoietic stem cell transplantation

(2012) A. Capotondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic–pituitary–adrenal axis

(2011) Theodore P. Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment

(2009) C. M.M. Prado et al.   CLINICAL CANCER RESEARCH

Protective effects of microglia in multiple sclerosis

(2009) Isabella Napoli et al.   EXPERIMENTAL NEUROLOGY

Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer

(2008) Jeannine Bachmann et al.   JOURNAL OF GASTROINTESTINAL SURGERY