Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL‐34, and SCF in amyotrophic lateral sclerosis

Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves

(2019) Kristjan R Jessen et al.   GLIA

Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

(2019) Jesus S. Mora et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Progressive Degeneration and Inhibition of Peripheral Nerve Regeneration in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2018) Binbin Deng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Temporal changes in macrophage phenotype after peripheral nerve injury

(2018) Joy E. Tomlinson et al.   Journal of Neuroinflammation

IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

(2018) Sonia Boulakirba et al.   Scientific Reports

A sub-population of Foxj1 expressing, non-myelinating Schwann cells of the peripheral nervous system contribute to Schwann cell remyelination in the central nervous system

(2018) Dan Ma et al.   JOURNAL OF NEUROSCIENCE

Macrophages Regulate Schwann Cell Maturation after Nerve Injury

(2018) Jo Anne Stratton et al.   Cell Reports

After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination

(2017) Jose A. Gomez-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

(2017) Jane A. Lindborg et al.   JOURNAL OF NEUROSCIENCE

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

(2017) Amanda Brosius Lutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Myelin and macrophages in the PNS: An intimate relationship in trauma and disease

(2016) Dennis Klein et al.   BRAIN RESEARCH

Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)

(2016) Jonathan M. Van Dyke et al.   EXPERIMENTAL NEUROLOGY

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

(2016) Emiliano Trias et al.   Journal of Neuroinflammation

Immune response in peripheral axons delays disease progression in SOD1G93A mice

(2016) Giovanni Nardo et al.   Journal of Neuroinflammation

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Unraveling gene expression profiles in peripheral motor nerve from amyotrophic lateral sclerosis patients: insights into pathogenesis

(2016) Nilo Riva et al.   Scientific Reports

CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves

(2016) Anna Martínez-Muriana et al.   Scientific Reports

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

(2016) Maria-Letizia Campanari et al.   Frontiers in Molecular Neuroscience

Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats

(2016) Masamichi Okubo et al.   PLoS One

Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot–Marie–Tooth disease in mice

(2015) Dennis Klein et al.   BRAIN

CSF-1-activated macrophages are target-directed and essential mediators of schwann cell dedifferentiation and dysfunction in Cx32-deficient mice

(2015) Janos Groh et al.   GLIA

Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model

(2015) D. Arbour et al.   JOURNAL OF NEUROSCIENCE

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Receptor-type Protein-tyrosine Phosphatase ζ Is a Functional Receptor for Interleukin-34

(2013) Sayan Nandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia

(2012) Melanie Greter et al.   IMMUNITY

Stem Cell Factor Programs the Mast Cell Activation Phenotype

(2012) T. Ito et al.   JOURNAL OF IMMUNOLOGY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Peripheral nerve inflammation in ALS mice: cause or consequence

(2012) O. Kano et al.   NEUROLOGY

Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X

(2011) Janos Groh et al.   BRAIN

Schwann Cell Proliferation and Macrophage Infiltration Are Evident at Day 14 after Painful Cervical Nerve Root Compression in the Rat

(2011) Yu-Wen Chang et al.   JOURNAL OF NEUROTRAUMA

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Mast cells and the neurofibroma microenvironment

(2010) K. Staser et al.   BLOOD

Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells

(2009) A. Florence Keller et al.   GLIA

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

(2009) Patrice Dubreuil et al.   PLoS One

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

(2009) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

(2009) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA