The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

(2019) Rebecca Bertolio et al.   Nature Communications

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling

(2019) Wei Zheng et al.   Cell Communication and Signaling

Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion

(2019) Celia Limia et al.   Cancers

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

(2017) Alexander R. van Vliet et al.   MOLECULAR CELL

ER Stress and Autophagy

(2015) W. Lee et al.   CURRENT MOLECULAR MEDICINE

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

(2015) C A Lewis et al.   ONCOGENE

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Autophagy regulates sphingolipid levels in the liver

(2014) Aikaterini Alexaki et al.   JOURNAL OF LIPID RESEARCH

Signaling Networks Converge on TORC1-SREBP Activity to Promote Endoplasmic Reticulum Homeostasis

(2014) Miguel Sanchez-Alvarez et al.   PLoS One

Autophagosomes contribute to intracellular lipid distribution in enterocytes

(2013) Salem Ait Khaldoun et al.   MOLECULAR BIOLOGY OF THE CELL

Minireview: Endoplasmic Reticulum Stress: Control in Protein, Lipid, and Signal Homeostasis

(2013) József Mandl et al.   MOLECULAR ENDOCRINOLOGY

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products

(2012) James R. Krycer et al.   BIOCHEMICAL JOURNAL

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site

(2010) Fabrizio Damiano et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Coxsackievirus B3 Infection Activates the Unfolded Protein Response and Induces Apoptosis through Downregulation of p58IPK and Activation of CHOP and SREBP1

(2010) H. M. Zhang et al.   JOURNAL OF VIROLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

PERK in beta cell biology and insulin biogenesis

(2010) Douglas R. Cavener et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lipophagy: Selective Catabolism Designed for Lipids

(2009) Hilla Weidberg et al.   DEVELOPMENTAL CELL

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells

(2009) T. Kawakami et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA