Signaling Networks Converge on TORC1-SREBP Activity to Promote Endoplasmic Reticulum Homeostasis

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Predicting functional gene interactions with the hierarchical interaction score

(2013) Berend Snijder et al.   NATURE METHODS

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the SREBP transcription factors by mTORC1: Figure 1

(2011) Caroline A. Lewis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity

(2011) Claudia Rubio et al.   JOURNAL OF CELL BIOLOGY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity

(2011) Claire E. Richardson et al.   PLoS Genetics

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The Role of Nuclear Receptor NHR-64 in Fat Storage Regulation in Caenorhabditis elegans

(2010) Bin Liang et al.   PLoS One

The Unfolded Protein Response Is Not Necessary for the G1/S Transition, but It Is Required for Chromosome Maintenance in Saccharomyces cerevisiae

(2010) Kelsey A. Henry et al.   PLoS One

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis: Fig. 1.

(2010) Mathieu Laplante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1: the last two decades

(2009) L H Glimcher   ANNALS OF THE RHEUMATIC DISEASES

LXR-SREBP-1c-Phospholipid Transfer Protein Axis Controls Very Low Density Lipoprotein (VLDL) Particle Size

(2009) Hiroaki Okazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions

(2008) Philip I. Merksamer et al.   CELL

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE