Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
XiaoYing Zheng, BingJun Peng, XinChun Wu, JunLing Ye, HaiYun Zhao, YanJun Li, RuiHui Chen, Xue Gong, HaiYan Zhang, XinJian Guo
Summary: The present study aims to investigate the regulatory effects and related mechanism of long noncoding RNA testis-specific transcript, Y-linked 15 (TTTY15) in gastric carcinoma (GC) cell proliferation, migration, invasion, apoptosis, and epithelial-mesenchymal transition (EMT). TTTY15 promotes GC progression by regulating the let-7a-5p/Wnt1 axis to activate the Wnt/β-catenin pathway.
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Multidisciplinary Sciences
Ahmet Acar, Ana Hidalgo-Sastre, Michael K. Leverentz, Christopher G. Mills, Simon Woodcock, Martin Baron, Giovanna M. Collu, Keith Brennan
Summary: Notch and Wnt are two essential signaling pathways in animals, with typically opposing effects on cell fate decisions. Notch can limit Wnt signaling through mechanisms at the cell membrane and in the cell nucleus, contributing to the robustness of cell fate decisions by sharpening the distinction between opposing Notch/Wnt responses.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Ruihong Li, Juan Liu, Jie Ma, Xuer Sun, Yi Wang, Jiexin Yan, Qunfang Yu, Jinmei Diao, Chun Yang, Lola M. Reid, Yunfang Wang
Summary: The liver functions depend on interactions between parenchymal cells and the microenvironment, with biological macromolecules in the matrix playing a key role. Rat liver biomatrix scaffold prepared from adult rats is more effective in enhancing hepatic spheroid function. Fibronectin and fibrinogen show potential for improving hepatocyte function, promoting cell aggregation and activating Wnt/beta-catenin pathway.
Article
Cell & Tissue Engineering
Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue, Zhijun Pan
Summary: The study showed that the silencing of SERPINB2 can promote osteogenic differentiation of BMSCs through the Wnt/β-catenin signaling pathway. In vivo experiments demonstrated that silencing SERPINB2 effectively improves bone fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Nianshuang Li, Yaobin Ouyang, Xinbo Xu, Zhenxiang Yuan, Chunquan Liu, Zhenhua Zhu
Summary: This study demonstrated that miR-155 plays a crucial role in regulating intestinal fibrosis, particularly in CD patients with intestinal stricture. Overexpression of miR-155 exacerbates CD-associated intestinal fibrosis. Mechanistically, miR-155 targets HBP1 to activate the Wnt/beta-catenin signaling pathway to induce intestinal fibrosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Roland Kotolloshi, Mieczyslaw Gajda, Marc-Oliver Grimm, Daniel Steinbach
Summary: The study revealed that BCL9L and Wnt/beta-catenin signaling play an oncogenic role in bladder cancer cells, and may be associated with the progression of bladder cancer. Mutations in UTRs of BCL9L can affect its activity, thereby influencing cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Li Shen, Jiping Zeng, Lin Ma, Shuyan Li, Chunyan Chen, Jihui Jia, Xiuming Liang
Summary: The NF-kappa B/LIN28A/let-7a axis plays a crucial role in promoting gastric cancer initiation, with H. pylori infection triggering its activation and leading to enhanced hTERT expression.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Haseeb Zubair, Mohammad Aslam Khan, Ajay Pratap Singh, Seema Singh
Summary: This study uncovers a novel signaling axis supporting the growth and stemness of breast cancer cells. The research identified resistin/LIN28A/Let-7a/IL-6/STAT3 as key components in this pathway, providing insights into the mechanisms underlying breast cancer development.
Article
Oncology
Chiara Giacomelli, Janine Jung, Astrid Wachter, Susanne Ibing, Rainer Will, Stefan Uhlmann, Heiko Mannsperger, Oezguer Sahin, Yosef Yarden, Tim Beissbarth, Ulrike Korf, Cindy Koerner, Stefan Wiemann
Summary: The study focuses on the regulatory role of miRNAs on three signaling pathways relevant to TNBC biology. Through high-throughput experiments and cell assays, miR-193b was identified as a significant repressor of cell proliferation and associated with the activity of these signaling pathways in TNBC patients.
Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Article
Oncology
Dan Li, Yuting Guo, She Tian, Changhao Zhu, Chengyi Sun
Summary: This study reveals the pro-carcinogenic role of CAV2 in pancreatic cancer through the activation of the Wnt7A/beta-catenin signaling pathway. miR-4723 is identified as an oncogene in pancreatic cancer, inhibiting CAV2 expression. These findings provide new targets and mechanisms for the treatment of pancreatic cancer.
Article
Obstetrics & Gynecology
Yingting Li, Huanchen Yan, Jingsi Chen, Fei Chen, Wei Jian, Jiayan Wang, Xiaoqing Ye, Yufan Li, Nan Li, Philip C. N. Chiu, Min Chen
Summary: The study found that late amniocentesis is effective in detecting late-onset fetal abnormalities, with high detection rates of chromosomal abnormalities. The incidence of preterm birth and intrauterine demise after amniocentesis was low. Chromosomal microarray analysis identified various abnormalities, with the highest diagnostic yield in fetuses with abnormal test results. Approximately 35.4% of pregnancies were terminated based on the results.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Immunology
Kunfeng Bai, Xintong Li, Jiangming Zhong, Ernest H. Y. Ng, William S. B. Yeung, Cheuk-Lun Lee, Philip C. N. Chiu
Summary: Exosomes, a subset of extracellular vesicles, play important roles in reproduction processes, especially during pregnancy. Placenta-derived exosomes (pEXO) in maternal blood could be potential biomarkers for pregnancy-related diseases. Furthermore, pEXO are key in establishing maternal immune tolerance during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Yingting Li, Liuying Zhong, Cheuk-Lun Lee, Philip C. N. Chiu, Min Chen
Summary: This study identified several proteins S-nitrosylated by ADM in JEG-3 placental cells, including tubulin, enolase, eukaryotic translation initiation factor 4A1, actin, ANX II, and glyceraldehyde 3-phosphate dehydrogenaseprotein-1. ADM significantly increased the surface expression of ANX II, but not its total expression, in JEG-3 cells, which could potentially impact trophoblast invasion and migration. Future studies are needed to further understand the roles of S-nitrosylated ANX II in trophoblast functions.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Ying Wang, Weie Zhao, Si Mei, Panyu Chen, Tsz-Ying Leung, Cheuk-Lun Lee, William S. B. Yeung, Jian-Ping Ou, Xiaoyan Liang, Philip C. N. Chiu
Summary: The protein C1orf56 was found to be a SLeX-binding protein on capacitated spermatozoa, playing a potential role in the acrosome reaction following sperm-egg binding. Clinical study showed an association between C1orf56 expression in the acrosome-reacted population and fertilization rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Urology & Nephrology
Erica T. Y. Leung, Cheuk-Lun Lee, Xinyi Tian, Kevin K. W. Lam, Raymond H. W. Li, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu
Summary: The review discusses current sperm selection methods and advances in selection technologies for assisted reproductive techniques, with a focus on their mechanisms, advantages, limitations, and clinical outcomes. It also introduces a conceptual sperm selection model using multiple mechanisms. The study suggests that traditional sperm selection based on density or motility may not accurately reflect fertilization competence, leading to potential risks of failed fertilization.
NATURE REVIEWS UROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Kunfeng Bai, Cheuk-Lun Lee, Xiaofeng Liu, Jianlin Li, Dandan Cao, Li Zhang, Duanlin Hu, Hong Li, Yanqing Hou, Yue Xu, Anita S. Y. Kan, Ka-Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu
Summary: This study investigates the role of first-trimester placenta-derived exosomes (pEXOs) in maternal immune tolerance during early pregnancy by reprogramming circulating monocytes. The results demonstrate that pEXOs target monocytes and induce an immunosuppressive phenotype, providing insights into the molecular mechanism of maternal immune tolerance.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Tianqi Li, Rachel W. S. Chan, Cheuk-Lun Lee, Philip C. N. Chiu, Raymond H. W. Li, Ernest H. Y. Ng, William S. B. Yeung
Summary: Endometrial mesenchymal stem-like cells (eMSC) are regulated by WNT/beta-catenin signaling through the interaction of WNT5A with FZD5 and LRP5, which control the proliferation and self-renewal of eMSC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Qingqing Zhang, Zhonglin Xiao, Cheuk-Lun Lee, Yong-Gang Duan, Xiujun Fan, William S. B. Yeung, Philip C. N. Chiu, Jian V. Zhang
Summary: The chemerin-CMKLR1 axis plays a crucial role in regulating placental development and spiral artery remodeling during pregnancy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Cheuk-Lun Lee, Zhilong Chen, Qingqing Zhang, Yue Guo, Vivian W. Y. Ng, Baozhen Zhang, Kunfeng Bai, Degong Ruan, Anita S. Y. Kan, Ka-Wang Cheung, Annisa S. L. Mak, William S. B. Yeung, Rui Su, Qing Yang, Min Chen, Mei-Rong Du, Zhang Jian, Xiujun Fan, Philip C. N. Chiu
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Xintong Li, Suranga P. Kodithuwakku, Rachel W. S. Chan, William S. B. Yeung, Yuanqing Yao, Ernest H. Y. Ng, Philip C. N. Chiu, Cheuk-Lun Lee
Summary: During implantation, the interaction between trophoblast and endometrium is crucial for successful pregnancy, with defective interaction leading to complications. In the past decade, various in vitro culture models have been established, but further research is needed to create a comprehensive model that can replicate the biology of trophoblast-endometrium interaction during early pregnancy.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Genetics & Heredity
Ye Liu, William S. B. Yeung, Philip C. N. Chiu, Dandan Cao
Summary: This article discusses the role of computational approaches in predicting the impact of genetic variants on phenotype, as the rapid development of next-generation sequencing and the lack of comprehensive databases and experimental evidence present challenges in studying genotype-phenotype relationships. The article categorizes the approaches and highlights their underlying rationale and constraints, while emphasizing the importance of computational predictive methods in exploring genotype-phenotype relationships.
FRONTIERS IN GENETICS
(2022)
Review
Obstetrics & Gynecology
Jianlin Li, Leqian Lin, Jiangming Zhong, Xintong Li, Cheuklun Lee, Philip C. N. Chiu
Summary: The endometrium is a dynamic organ that undergoes physiological and functional alteration during the menstrual cycle. The development of the three-dimensional endometrial organoid system provides a powerful tool to study the normal endometrium and its related diseases.
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE
(2022)
Article
Cell Biology
Zhongzhen Liu, Man Zhai, Qingqing Zhang, Tingyu Yang, Zunmin Wan, Jianlin Li, Xiaofeng Liu, Bo Xu, Libei Du, Rachel W. S. Chan, Li Zhang, William S. B. Yeung, Ka Wang Cheung, Philip C. N. Chiu, Wen-Jing Wang, Cheuk-Lun Lee, Ya Gao
Summary: This study described the landscape of spatial transcriptome of human placental villi and identified the main cell types and regulatory pathways. The results provide valuable insights for further investigation of placenta development, physiology, and pathology in a spatial context.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Degong Ruan, Zi-Wei Ye, Shuofeng Yuan, Zhuoxuan Li, Weiyu Zhang, Chon Phin Ong, Kaiming Tang, Timothy Theodore Ka Ki Tam, Jilong Guo, Yiyi Xuan, Yunying Huang, Qingqing Zhang, Cheuk-Lun Lee, Liming Lu, Philip C. N. Chiu, William S. B. Yeung, Fang Liu, Dong-Yan Jin, Pentao Liu
Summary: Human placenta trophoblasts and their derivatives are susceptible to SARS-CoV-2 infection, with early syncytiotrophoblasts displaying high infectivity. These findings highlight the potential risk of COVID-19 infection during embryonic implantation.
CELL REPORTS MEDICINE
(2022)
Article
Cell Biology
Kunfeng Bai, Jianlin Li, Leqian Lin, Qingqing Zhang, Jiangming Zhong, Xiaofeng Liu, Dandan Cao, Yong-Gang Duan, Yuanqing Yao, Raymond H. W. Li, Ka-Wang Cheung, William S. B. Yeung, Philip C. N. Chiu, Cheuk-Lun Lee
Summary: Exosomes derived from human placenta can induce macrophage polarization to acquire a decidual-like macrophage phenotype by miRNA-30d-5p/histone deacetylase 9 axis. These placenta-derived exosomes also promote trophoblast migration and invasion while impairing endothelial cell tube formation and migration. However, they do not affect T-cell proliferation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
