Article
Biochemistry & Molecular Biology
Beatriz Martin-Carro, Julia Martin-Virgala, Sara Fernandez-Villabrille, Alejandra Fernandez-Fernandez, Marcos Perez-Basterrechea, Juan F. Navarro-Gonzalez, Javier Donate-Correa, Carmen Mora-Fernandez, Adriana S. Dusso, Natalia Carrillo-Lopez, Sara Panizo, Manuel Naves-Diaz, Jose L. Fernandez-Martin, Jorge B. Cannata-Andia, Cristina Alonso-Montes
Summary: Fibrosis plays a crucial role in the development of diabetic complications and dysfunction in the heart and kidneys. This study investigated the involvement of soluble Klotho, advanced glycation end products/receptor for AGEs, fibrotic Wnt/beta-catenin pathway, and pro-fibrotic pathways in the kidney and heart of diabetic rats. The findings suggested that diabetic rats had elevated levels of urinary sKlotho, AGEs, and sRAGE, and decreased levels of serum sKlotho. Fibrosis and RAGE levels were higher in the heart of diabetic rats compared to controls. The increase in sKlotho and sRAGE excretion may be due to polyuria in diabetic rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
Summary: We found that A2aR inhibits fibrosis and the EMT process in silicosis by regulating the Wnt/β-catenin pathway. Our study provides an experimental basis for elucidating the role of A2aR in the development of silicosis and offers new ideas for further exploration of interventions for silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng, Mingchang Zhang
Summary: The study revealed that circ_0119872 is upregulated in UM cell lines and tissues, promoting the malignancy of UM cells. Additionally, circ_0119872 can directly interact with miR-622, acting as a miRNA sponge to regulate the expression of the miR-622 target gene G3BP1 and downstream Wnt/beta-catenin and mTOR signaling pathways.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Siwei Yu, Ruyue Han, Runliang Gan
Summary: This review aims to analyze the mechanisms of action of related molecules in the Wnt/beta-catenin pathway in hematologic malignancies and explore their feasibility as therapeutic targets.
BIOMARKER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yan-Ni Wang, Hong-Jiao Liu, Li-Li Ren, Ping Suo, Liang Zou, Ya-Mei Zhang, Xiao-Yong Yu, Ying-Yong Zhao
Summary: Chronic kidney disease (CKD) is a major global public health problem with a projected increase in patients in the coming decades. Shenkang injection (SKI) may ameliorate CKD by inhibiting the activation of multiple RAS genes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Paria Bayati, Marjan Taherian, Mansoureh Soleimani, Hamid Farajifard, Nazanin Mojtabavi
Summary: This study assessed the potential of induced pluripotent stem cells (IPS) in modulating the expression of cardinal genes involved in the Wnt signaling pathway in a mouse model of idiopathic pulmonary fibrosis (IPF). The results showed that IPS cell treatment significantly alleviated fibrotic lesions and inflammation, and regulated the expression of key genes in the Wnt pathway.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Food Science & Technology
Yang Li, Junfei Chen, Dong Sun, Jingwei Liu, Zhe Wang, Aiwu Li
Summary: LGG administration can alleviate intestinal lesions in NEC by restoring intestinal flora, activating Wnt/β-catenin signaling pathway, promoting ISC regeneration, increasing the number of TJs, and improving intestinal barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell & Tissue Engineering
Kai Hang, Li Ying, Jinwu Bai, Yibo Wang, Zhihui Kuang, Deting Xue, Zhijun Pan
Summary: The study showed that the silencing of SERPINB2 can promote osteogenic differentiation of BMSCs through the Wnt/β-catenin signaling pathway. In vivo experiments demonstrated that silencing SERPINB2 effectively improves bone fracture healing, suggesting that SERPINB2 may be a novel target for bone fracture healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Agriculture, Multidisciplinary
Duoduo Zhang, Xingtao Zhou, Linyuan Liu, Mi Guo, Tongwen Huang, Wengan Zhou, Fang Geng, Steve W. Cui, Shaoping Nie
Summary: The study revealed that glucomannan from Aloe vera gel promoted proliferation and differentiation of intestinal stem cells through the Wnt/β-catenin signaling pathway, facilitating epithelial cell regeneration and alleviating colitis in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell & Tissue Engineering
Jia-yi Zhou, Deng-gui Huang, Chun-qi Gao, Hui-chao Yan, Shi-geng Zou, Xiu-qi Wang
Summary: The study found that STp inhibits intestinal stem cell expansion and disrupts intestinal mucosa integrity by downregulating the Wnt/beta-catenin signaling pathway.
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lifang He, Qingke Li, Chunyang Du, Yanyun Xue, Pei Yu
Summary: This study found that Glis2 expression was downregulated in Diabetic kidney disease (DKD) and overexpression of Glis2 inhibited the apoptosis and epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells (TECs). Furthermore, Glis2 overexpression also suppressed the activation of the beta-catenin signaling pathway, which played a role in protecting against tubular injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Jin Lu, Yongsheng Yang, Xiangliang Liu, Xiao Chen, Wei Song, Zefeng Liu
Summary: This study identified a novel regulatory mechanism in the development of resistance to gemcitabine (GEM) in pancreatic ductal adenocarcinoma (PDAC). LINC01134 was found to promote PDAC resistance to GEM through facilitating stem cell features and modulating the cell cycle. Mechanistically, LINC01134 interacted with tumor suppressor miR-497-5p and increased LINC01134 downregulated miR-140-3p to promote expression of oncogenic WNT5A. Additionally, the m6A demethylase FTO played a role in the upregulation of LINC01134 by maintaining LINC01134 mRNA stability through YTHDF2.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yalan Dong, Heng Fan, Zhe Zhang, Feng Jiang, Mingyue Li, Haifeng Zhou, Weina Guo, Zili Zhang, Zhenyu Kang, Yang Gui, Zhexing Shou, Junyi Li, Rui Zhu, Yu Fu, Alexey Sarapultsev, Huafang Wang, Shanshan Luo, Ge Zhang, Desheng Hu
Summary: In this study, the therapeutic effect and mechanism of berberine (BBR) in treating DSS-induced colitis were investigated. It was found that BBR can reduce colon inflammation, regulate the abundance and composition of bacteria, restore the broken chemical and epithelial barriers, and modulate the expression of various immune factors. The protective effect of BBR was also observed through the enhancement of the Wnt/beta-catenin pathway. These findings suggest that BBR serves as a potential gut microbiota modulator and mucosal barrier protector for UC prevention and therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jing Liu, Xuehui Zheng, Chen Zhang, Chunmei Zhang, Peili Bu
Summary: The study demonstrated that ARNI alleviated myocardial fibrosis by inhibiting the Wnt/beta-catenin signaling pathway and overexpressing sFRP-1, thereby improving cardiac function.
FRONTIERS IN PHARMACOLOGY
(2021)