Global miRNA and mRNA expression profiles identify miRNA‐26a‐2‐3p‐dependent repression of IFN signature in systemic sclerosis human monocytes

Safety and tolerability of anifrolumab, a monoclonal antibody targeting type I interferon receptor, in Japanese patients with systemic lupus erythematosus: A multicenter, phase 2, open-label study

(2019) Yoshiya Tanaka et al.   Modern Rheumatology

Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting

(2019) Maarten van der Kroef et al.   ANNALS OF THE RHEUMATIC DISEASES

Mesenchymal stem cells of Systemic Sclerosis patients, derived from different sources, show a profibrotic microRNA profiling

(2019) Paola Di Benedetto et al.   Scientific Reports

Changes in macrophage transcriptome associate with systemic sclerosis and mediateGSDMAcontribution to disease risk

(2018) Aida Moreno-Moral et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of glucocorticoids on miRNA expression spectrum of rat femoral head microcirculation endothelial cells

(2018) Ju'an Yue et al.   GENE

Targeting interferons as a strategy for systemic sclerosis treatment

(2018) Marzena Ciechomska et al.   IMMUNOLOGY LETTERS

Phenotypic and Transcriptomic Analysis of Peripheral Blood Plasmacytoid and Conventional Dendritic Cells in Early Drug Naïve Rheumatoid Arthritis

(2018) Faye A. H. Cooles et al.   Frontiers in Immunology

New insights into the genetics and epigenetics of systemic sclerosis

(2018) Chiara Angiolilli et al.   Nature Reviews Rheumatology

The role of microRNA-5196 in the pathogenesis of systemic sclerosis

(2017) Marzena Ciechomska et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

IRF7 gene expression profile and methylation of its promoter region in patients with systemic sclerosis

(2017) Ramazan Rezaei et al.   International Journal of Rheumatic Diseases

Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis

(2017) Marzia Rossato et al.   Arthritis & Rheumatology

The Role of Interferons in Inflammation and Inflammasome Activation

(2017) Nataša Kopitar-Jerala   Frontiers in Immunology

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease

(2016) Tracy A. Delaney et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Modulation as a Therapeutic Prospect for Treatment of Autoimmune Rheumatic Diseases

(2016) Marzena Ciechomska et al.   MEDIATORS OF INFLAMMATION

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics

(2016) Steven O’Reilly et al.   Scientific Reports

Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2

(2016) Marzena Ciechomska et al.   Arthritis & Rheumatology

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

(2015) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis

(2015) Xiang Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis

(2014) Marzena Ciechomska et al.   PLoS One

MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats

(2014) Congshan Jiang et al.   ARTHRITIS RESEARCH & THERAPY

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors

(2012) Marzena Ciechomska et al.   ANNALS OF THE RHEUMATIC DISEASES

MicroRNA-466l inhibits antiviral innate immune response by targeting interferon-alpha

(2012) Yingke Li et al.   Cellular & Molecular Immunology

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

The role of miR-26 in tumors and normal tissues (Review)

(2011) JIE GAO et al.   Oncology Letters

Type I interferon system activation and association with disease manifestations in systemic sclerosis

(2010) M.-L. Eloranta et al.   ANNALS OF THE RHEUMATIC DISEASES

A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis

(2010) G. Farina et al.   ARTHRITIS AND RHEUMATISM

MicroRNA Regulation of IFN-β Protein Expression: Rapid and Sensitive Modulation of the Innate Immune Response

(2010) Kenneth W. Witwer et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs: Small RNAs With Big Effects

(2010) Dany Anglicheau et al.   TRANSPLANTATION

Interferon   for rheumatoid arthritis: new clothes for an old kid on the block

(2009) M. J Vervoordeldonk et al.   ANNALS OF THE RHEUMATIC DISEASES

Human monocytes represent a competitive source of interferon-α in peripheral blood

(2008) Leo Hansmann et al.   CLINICAL IMMUNOLOGY