Article
Immunology
Seung-Ji Kang, Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho, Tae Hoon Oh, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Sook-In Jung, Tae-Ok Kim, Hyo Shin Kim, Young-Goun Jo, Jae Kyun Ju, Seung-Jung Kee, Yong-Wook Park
Summary: This study reveals that circulating pDCs and cDCs are numerically deficient and functionally impaired in scrub typhus patients. Changes in the expression levels of surface phenotypes of pDCs and cDCs may be influenced by pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Leah Pretsch, Michael Fichter, Maximiliano L. Cacicedo, Heloise Therien-Aubin, Katharina Landfester, Stephan Gehring
Summary: Childhood mortality is a significant issue, with a large number of deaths attributed to preventable infectious diseases. The study demonstrates the superior ability of the TLR7/8 agonist R848 in activating the immune system of both adults and neonates. Furthermore, R848 can be efficiently delivered along with antigens using nanocapsules, offering new possibilities for vaccine development.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Yaling Tian, Ping Shi, Yan Zhou, Rui Yuan, Zhicheng Hu, Yan Tan, Guilan Ma, Lei Yang, Hongmei Jiang
Summary: The study successfully constructed tolDCs, and found that they had long-term tolerogenic potential in vivo, which could improve arthritis in CIA rats with different severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Xavier Roussel, Francine Garnache Ottou, Florian Renosi
Summary: Plasmacytoid dendritic cells (pDC) are the main type I interferon-producing cells in humans and are capable of regulating innate and adaptive immune responses. Tumor infiltration by pDC is well-documented in various cancers and is associated with unfavorable clinical outcomes. While Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN) is a well-described aggressive leukemia derived from pDCs, the understanding of tumor infiltration by mature pDCs in Myeloid Neoplasms (MN) is limited. This review aims to provide a comprehensive overview of pDC biology in MN, emphasizing the need for further research into pDC oncogenesis and immune responses for better therapeutic strategies.
Article
Immunology
Laura C. Van Eyndhoven, Eleni Chouri, Nikita Subedi, Jurjen Tel
Summary: Plasmacytoid dendritic cells (pDCs) are a rare type of immune cells with specialized functions in producing large amounts of type I interferon (IFN-I) and exerting cytotoxic effects. Studies show that only a small percentage of pDCs respond to activation by toll-like receptors with IFN alpha secretion and upregulation of cytotoxic markers. The early IFN-producing pDCs, known as first responders, exhibit high expression of PD-L1 and TRAIL, while IFN-I primed cells increase IFN alpha production but do not significantly enhance cytotoxicity. Through droplet-based microfluidics, researchers observed that first responders play a key role in orchestrating population-wide IFN-I responses and have a high cytotoxic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ziqiang Shuai, Shuang Zheng, Kang Wang, Jian Wang, Patrick S. C. Leung, Bin Xu
Summary: Researchers are actively exploring new approaches to treat rheumatoid arthritis through methods such as stem cell transplantation, tolerogenic dendritic cells, and antigen-based tolerogenic vaccines. Current clinical trials show promising results in terms of safety and effectiveness in restoring immune balance and improving symptoms through stem cell transplantation and tolerogenic dendritic cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Simone P. Sittig, Jasper J. P. van Beek, Georgina Florez-Grau, Jorieke Weiden, Sonja Buschow, Mirjam C. van der Net, Rianne van Slooten, Marcel M. Verbeek, P. Ben H. Geurtz, Johannes Textor, Carl G. Figdor, I. Jolanda M. de Vries, Gerty Schreibelt
Summary: Dendritic cells play a crucial role in shaping T cell responses through regulation of the enzyme IDO. The activity of IDO in conventional DCs inhibits T cell proliferation, but can be rescued by using an IDO1 inhibitor.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Adan Chari Jirmo, Ruth Grychtol, Svenja Gaedcke, Bin Liu, Stephanie DeStefano, Christine Happle, Olga Halle, Joao T. Monteiro, Anika Habener, Oliver D. Breiholz, David DeLuca, Gesine Hansen
Summary: Through analysis of pulmonary DCs at single cell resolution, we found the existence of a pulmonary cDC1 cluster lacking Xcr1, which has an immunogenic signature distinct from the Xcr1 positive cDC1 cluster. This finding has important implications for DC-targeting immunomodulatory therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yuichi Suwa, Yasuo Nagafuchi, Saeko Yamada, Keishi Fujio
Summary: Dendritic cells (DCs) have important roles in the pathogenesis of rheumatoid arthritis (RA), characterized by chronic synovitis and joint destruction. Conventional dendritic cells (cDCs) in the synovium show enhanced migratory capacities and T cell activation compared to peripheral blood cDCs, while plasmacytoid dendritic cells in RA may have tolerogenic effects. Monocyte-derived dendritic cells (moDCs) in the synovium induce expansion of T-helper 17 cells and proinflammatory cytokine production. Recent studies suggest a link between proinflammatory hypoxic environments in the synovium and metabolic reprogramming of DCs. Targeting the immunometabolism of DCs could be a potential therapeutic approach in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Qifeng Zhong, Yong Lu, Wenlong Xu, Zhien Rong, Xu Chang, Li Qin, Xiaoping Chen, Fang Zhou
Summary: NSCLC cells have a modulating effect on the protein expression of CD86 and HLA-DR on CD303(+) pDCs, as well as on the production of cytokines like IL-12, IL-23, IL-27, and TGF-beta by these cells. Additionally, NSCLC cells regulate the development of CD303(+) pDC subsets expressing CD205 and/or CD103 through the modulation of protein expression on these cells. This may ultimately contribute to the creation of an immune-suppressive microenvironment induced by NSCLC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giulio Verna, Marina Liso, Elisabetta Cavalcanti, Giusy Bianco, Veronica Di Sarno, Angelo Santino, Pietro Campiglia, Marcello Chieppa
Summary: Dendritic cells can be divided into myeloid dendritic cells and plasmacytoid dendritic cells, which play important roles in regulating immune responses. Inflammatory bowel diseases are characterized by leaky intestinal barrier and translocation of bacterial lipopolysaccharide. It was found that quercetin can modulate dendritic cell responses through a specific molecular pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Andrew S. Nelson, Ali Akgul, Massimo Maddaloni, Ella Bhagyaraj, Carol Hoffman, David W. Pascual
Summary: CFA/I fimbriae can influence specific DC populations to establish tolerance, initially through bystander suppression and ultimately dependent on the activation of Tregs. Infection of BMDCs with LL-CFA/I promotes the production of IL-10, TGF-beta, and IDO, while suppressing TNF-alpha and IFN-gamma production.
IMMUNOLOGY LETTERS
(2021)
Review
Oncology
Florian Renosi, Mary Callanan, Christine Lefebvre
Summary: This review discusses the differential diagnosis between Blastic pDC Neoplasm (BPDCN) and Acute Myeloid Leukemia with pDC expansion (pDC-AML) and their genomic features. Understanding the distinct characteristics of these two diseases is crucial for diagnosis and treatment.
Article
Immunology
Hanna Abberger, Romy Barthel, Jasmin Bahr, Jacqueline Thiel, Sina Luppus, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: The study found that in activated CD4(+) non-Tregs, Nrp-1 expression has an activating role, while in CD4(+) non-Tregs from naive mice, Nrp-1 expression leads to dysfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuanhao Zhao, Xiaoyan Chen, Penghui He, Xuanyu Wang, Yanhua Xu, Rui Hu, Yangsen Ou, Zhihua Zhang, Zhibing Zhang, Guangsheng Du, Xun Sun
Summary: This study investigated the use of a transdermal microneedle patch to deliver CII peptide autoantigen and rapamycin for the treatment of rheumatoid arthritis. The microneedles effectively recruited antigen-presenting cells and induced tolerogenic dendritic cells, leading to the activation of Treg cells and the suppression of proinflammatory cytokines, ultimately eliminating RA symptoms. Low dose of rapamycin was found to be crucial for successful immune tolerance induction. This rationally designed microneedle patch shows promise for immune balance restoration and improved patient compliance.
Article
Rheumatology
Charlotte L. M. Krieckaert, Astrid van Tubergen, Johanna Elin Gehin, Borja Hernandez-Breijo, Guillaume Le Meledo, Alejandro Balsa, Peter Boehm, Sasa Cucnik, Ori Elkayam, Guro L. Goll, Femke Hooijberg, Meghna Jani, Patrick D. W. Kiely, Neil McCarthy, Denis Mulleman, Victoria Navarro-Compan, Katherine Payne, Martin E. Perry, Chamaida Plasencia-Rodriguez, Simon R. Stones, Silje Watterdal Syversen, Annick de Vries, Katherine M. Ward, Gertjan Wolbink, John D. Isaacs
Summary: This study develops EULAR points-to-consider for therapeutic drug monitoring (TDM) of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases (RMDs). The points-to-consider are evidence-based and consensus-based statements that highlight the clinical utility of TDM. However, the lack of high quality trials addressing effectiveness and safety of TDM, as well as robust economic evaluation, limits its wider adoption.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Daniel Aletaha, Andreas Kerschbaumer, Kastriot Kastrati, Christian Dejaco, Maxime Dougados, Iain B. McInnes, Naveed Sattar, Tanja A. Stamm, Tsutomu Takeuchi, Michael Trauner, Desiree van der Heijde, Marieke Voshaar, Kevin L. Winthrop, Angelo Ravelli, Neil Betteridge, Gerd-Ruediger R. Burmester, Johannes W. J. Bijlsma, Vivian Bykerk, Roberto Caporali, Ernest H. Choy, Catalin Codreanu, Bernard Combe, Mary K. Crow, Maarten de Wit, Paul Emery, Roy M. Fleischmann, Cem Gabay, Merete Lund Hetland, Kimme L. Hyrich, Annamaria Iagnocco, John D. Isaacs, Joel M. Kremer, Xavier Mariette, Peter Merkel, Eduardo F. Mysler, Peter Nash, Michael T. Nurmohamed, Karel Pavelka, Gyula Poor, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Anja Strangfeld, Yoshiya Tanaka, Josef S. Smolen
Summary: This paper is an updated consensus document on the medical use of IL-6 pathway inhibition in the treatment of inflammatory diseases. The document provides comprehensive consensus statements based on systematic literature research and expert opinion, covering various aspects of IL-6 pathway inhibitors, including dosing, indications, and clinical considerations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Gemma Vidal-Pedrola, Najib Naamane, James A. Cameron, Arthur G. Pratt, Andrew L. Mellor, John D. Isaacs, Dagmar Scheel-Toellner, Amy E. Anderson
Summary: Age-associated B cells (ABCs) are an immune cell subset linked to autoimmunity, infection, and aging. Studies have shown that ABCs in the peripheral blood of patients with early rheumatoid arthritis (eRA) exhibit distinct transcriptional characteristics compared to control groups, and they are found to be abundant in synovial fluid. These activated B cells express chemokine receptors and adhesion molecules that favor inflammation over lymphoid tissue, and they may play a role in autoimmune pathology due to their antigen presentation and pro-inflammatory phenotype.
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Review
Rheumatology
Kevin Winthrop, John Isaacs, Leonard Calabrese, Deepali Mittal, Supriya Desai, Jane Barry, Sander Strengholt, James Galloway
Summary: A literature review of clinical trials found that the use of JAK inhibitors for rheumatoid arthritis is associated with opportunistic infections, with herpes zoster being the most common. Higher rates of infections were observed in Asian and Australian populations, as well as with increasing doses of JAK inhibitors.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Review
Engineering, Biomedical
Daniel Salthouse, Katarina Novakovic, Catharien M. U. Hilkens, Ana Marina Ferreira
Summary: This review highlights the importance of the immune response to biomaterials and discusses challenges and opportunities in the development and standardized assessment of the immune response to biomaterials, including the importance of endotoxin levels. It also explores the properties of biomaterials that impact the host immune response and the use of immunomodulatory biomaterials in regenerative medicine. Finally, a standardized in vitro pathway for evaluating the immune response to biomaterials (hydrogels) and their regenerative potential is proposed to ensure safety, consistency, and reduce costs and animal use.
ACTA BIOMATERIALIA
(2023)
Review
Immunology
Kristian C. Williams, Abigail Gault, Amy E. Anderson, Christopher J. Stewart, Christopher A. Lamb, R. Ally Speight, Neil Rajan, Ruth Plummer, Arthur G. Pratt
Summary: Checkpoint inhibitors (CPIs) disrupt immune checkpoint molecules to block regulatory immune signals, but can cause immune-related adverse events (irAEs) similar to autoimmune diseases. Understanding irAE pathobiology may lead to targeted mitigation strategies and predictive biomarkers. This review focuses on irAEs in the gut, skin, and synovial joints, comparing them to immune-mediated diseases. Studies show dysregulation of cytokines, T-cell infiltration, and potential therapeutic opportunities for irAEs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Lisa Irving, Toby O. Smith, Vipul I. Mandalia, Arthur Pratt, Daniel Dowen
Summary: This study investigated the decision-making of orthopaedic surgeons and physiotherapists regarding surgical or non-operative treatment for patients with recurrent patellar dislocations. The results showed some disparity between the professions on when to perform surgical assessments and non-operative management, with physiotherapists more likely to delay a surgical opinion.
MUSCULOSKELETAL CARE
(2023)
Article
Rheumatology
Samantha Louise Smith, Sheree Alexander, Nisha Nair, Sebastien Viatte, Stephen Eyre, Kimme L. Hyrich, Ann W. Morgan, Anthony G. Wilson, John D. Isaacs, Darren Plant, Anne Barton
Summary: The study aimed to explore whether the inflammatory protein MRP8/14 can serve as a biomarker for treatment response in rheumatoid arthritis (RA) patients receiving tumor necrosis factor (TNF) inhibitors. The results showed that in the 3-component and 2-component models, patients with high pre-treatment levels of MRP8/14 were 1.92 and 2.03 times more likely to be classified as EULAR responders compared to those with low levels. However, no significant associations were observed in the 4-component model. Conclusion: Apart from its correlation with CRP, there is no evidence to suggest that MRP8/14 explains additional variability in response to TNFi in RA patients beyond CRP alone.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Joshua. L. L. Bennett, Arthur. G. G. Pratt, Richard Dodds, Avan. A. A. Sayer, John. D. D. Isaacs
Summary: Sarcopenia, characterized by the loss of skeletal muscle strength and mass, is commonly associated with rheumatoid arthritis. This review discusses the epidemiology, pathophysiology, and identification of rheumatoid sarcopenia, as well as the therapeutic roles of physical activity, nutrition, and pharmacotherapy. Rheumatoid sarcopenia is highly prevalent (>= 25%) in individuals with rheumatoid arthritis and is associated with increased risk of falls, fractures, and physical disability.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Rheumatology
Daniel Maunder, Philip M. Brown, Ben Barron-Millar, Dennis W. Lendrem, Najib Naamane, Jamie Macdonald, Xiao N. Wang, John D. Isaacs, Amy E. Anderson, Ann W. Morgan, Rachel E. Crossland, Sarah L. Mackie, Arthur G. Pratt
Summary: This study evaluated the potential of serum EV miRs as diagnostic and therapeutic biomarkers in early RA and found a novel potential mechanism by which MTX may exert its therapeutic effect in early RA.
Article
Cell Biology
Kelsey N. S. Thompson, Kevin S. E. Bonham, Nicholas E. J. Ilott, Graham J. Britton, Paula J. Colmenero, Samuel J. J. Bullers, Lauren J. McIver, Siyuan H. Ma, Long H. Nguyen, Andrew Filer, India Brough, Claire Pearson, Caroline Moussa, Vinod H. Kumar, Lilian H. A. Lam, Matthew A. Jackson, April Pawluk, Serafim R. Kiriakidis, Peter C. Taylor, Lucy R. P. Wedderburn, Brian R. Marsden, Stephen P. J. Young, Dan R. G. Littman, Jeremiah J. Faith, Arthur G. Pratt, Paul Bowness, Karim Raza, Fiona Powrie, Curtis Huttenhower
Summary: Musculoskeletal diseases impact 20% of adults globally. The connection between gut microbiome and inflammatory conditions, like arthritis, has not been fully understood. The Inflammatory Arthritis Microbiome Consortium analyzed 440 stool samples and found differential microbiome composition and functional processes in patients with inflammatory arthritis compared to healthy individuals. This research enhances our understanding of how systemic inflammation during arthritis affects the gut ecosystem.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Rheumatology
Gwenda Simons, Rebecca Birch, Joanne Stocks, Elspeth Insch, Rob Rijckborst, Georgiana Neag, Heidi Mccolm, Leigh Romaniuk, Claire Wright, Bethan E. Phillips, Simon W. Jones, Arthur G. Pratt, Stefan Siebert, Karim Raza, Marie Falahee
Summary: This paper describes the development and evaluation of the Student Patient Alliance (SPA), a program that connects PPI partners with doctoral students. Both students and their PPI partners reported positive impacts on understanding, motivation, and communication skills. The SPA is valued and likely to enhance students' PPI and public engagement skills and awareness of patients' experiences on a wider scale.
Article
Rheumatology
Ciara D. O'Brien, George Kitas, Fiona D. Rayner, John F. Isaacs, Kenneth G. Baker, Arthur D. Pratt, Christopher Buckley, Karim Raza, Andrew Filer, Stefan Siebert, Iain McInnes, Andrew McGucken, Sally A. M. Fenton, BIOFLARE Consortium
Summary: This study aimed to determine the minimum number of monitoring days required to reliably estimate sedentary time, light-intensity physical activity, and moderate-intensity physical activity in people with Rheumatoid Arthritis (RA) across different levels of disease activity. The results showed that at least 4 monitoring days were required to reliably estimate sedentary time and light-intensity physical activity, while at least 5 monitoring days were required to reliably estimate behaviors across the movement continuum. This information is important for accurately assessing physical activity levels and sedentary behavior in RA patients and can help inform interventions for promoting physical activity and reducing sedentary time.
RHEUMATOLOGY INTERNATIONAL
(2023)