DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling

Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6

(2018) G. R. Vanaja et al.   Cell Communication and Signaling

Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study

(2018) Ayse Sahin-Efe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

mTOR signaling in X/A-like cells contributes to lipid homeostasis in mice

(2018) Ziru Li et al.   HEPATOLOGY

DOCK2 deficiency mitigates HFD-induced obesity by reducing adipose tissue inflammation and increasing energy expenditure

(2017) Xia Guo et al.   JOURNAL OF LIPID RESEARCH

Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry

(2017) Mengliu Yang et al.   Cell Death & Disease

Requirement for CCNB1 in mouse spermatogenesis

(2017) Ji-Xin Tang et al.   Cell Death & Disease

Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation

(2017) Pazhanichamy Kalailingam et al.   Scientific Reports

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1

(2017) Hirotada Tajiri et al.   Cell Reports

The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications

(2017) Yee-How Say   Journal of Physiological Anthropology

USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors

(2017) Caitlin R. Bridges et al.   Scientific Reports

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

(2016) Qi Gong et al.   HEPATOLOGY

The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion

(2016) S R Frank et al.   ONCOGENE

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

(2015) Roel A van der Heijden et al.   Aging-US

A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration

(2015) Xuan Cao et al.   Nature Communications

Glypican-4 is increased in human subjects with impaired glucose tolerance and decreased in patients with newly diagnosed type 2 diabetes

(2014) Ke Li et al.   ACTA DIABETOLOGICA

Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats

(2014) D. Wu et al.   DIABETES

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

(2014) Hongfeng Jiang et al.   DIABETOLOGIA

Overexpression of juxtaposed with another zinc finger gene 1 reduces proinflammatory cytokine release via inhibition of stress-activated protein kinases and nuclear factor-κB

(2014) Mengliu Yang et al.   FEBS Journal

DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation

(2014) Kana Ogawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation

(2014) Mayuki Watanabe et al.   JOURNAL OF IMMUNOLOGY

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

(2013) Yu Li et al.   GASTROENTEROLOGY

Phosphatidic Acid-dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation

(2013) Fumiyuki Sanematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity

(2012) Julia S. El-Sayed Moustafa et al.   HUMAN MOLECULAR GENETICS

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (DOCK) Nucleotide Exchange Factors

(2011) Kiran Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

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(2011) Ling Li et al.   MOLECULAR MEDICINE

Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1

(2010) M. V. Hoang et al.   BLOOD

The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts

(2010) Virginie Vives et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chronic Inhibition of the mTORC1/S6K1 Pathway Increases Insulin-Induced PI3K Activity but Inhibits Akt2 and Glucose Transport Stimulation in 3T3-L1 Adipocytes

(2010) Alain Veilleux et al.   MOLECULAR ENDOCRINOLOGY

GeneCards Version 3: the human gene integrator

(2010) M. Safran et al.   Database-The Journal of Biological Databases and Curation

Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation

(2008) Tsukasa Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The adipose triglyceride lipase, adiponectin and visfatin are downregulated by tumor necrosis factor-α (TNF-α) in vivo

(2008) Ling Li et al.   CYTOKINE

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo

(2008) M. Laurin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA