Article
Neurosciences
M. Adrienne McGinn, Brendan J. Tunstall, Joel E. Schlosburg, Adriana Gregory-Flores, Olivier George, Giordano de Guglielmo, Barbara J. Mason, Hazel J. Hunt, George F. Koob, Leandro F. Vendruscolo
Summary: The study demonstrated the potential of GR modulators in reducing alcohol consumption, with different effects observed in different circumstances. These findings provide insights for the development of treatments for AUD.
Article
Substance Abuse
Jared R. Bagley, Elissa J. Chesler, Vivek M. Philip, James D. Jentsch
Summary: Genetic factors play a role in voluntary ethanol consumption and pharmacokinetics, with different mouse populations showing varying levels of genetic diversity. The PWK/PhJ strain exhibits the highest ethanol consumption, and it was found that sex moderates genetic effects on voluntary ethanol drinking.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
Ryan Patwell, Hyerim Yang, Subhash C. Pandey, Elizabeth J. Glover
Summary: The study identified three distinct operant phenotypes for ethanol intake and highlighted important strain differences in appetitive and consummatory behaviors. The findings suggest that increased incentive for ethanol, rather than palatability, drives greater consumption in Drinkers compared to Responders. Furthermore, withdrawal from chronic ethanol exposure resulted in increased appetitive responding in both Drinkers and Responders, but only Drinkers exhibited a concomitant increase in ethanol consumption.
Article
Neurosciences
Margo Slomp, Laura L. L. Koekkoek, Michael Mutersbaugh, Ian Linville, Serge H. H. Luquet, Susanne E. E. la Fleur
Summary: Nutrition can affect the brain's regulation of food intake, and the interaction between fat and sugar on the brain's lateral hypothalamus (LH) is hypothesized. This study found that a high-fat diet decreases overall GABAergic activity in the LH, but does not affect the response to sugar. Further research is needed to determine how this inhibition of LH GABAergic activity contributes to hyperphagia and obesity development.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Lindsay A. Sobotka, Khalid Mumtaz, Alice Hinton, Lanla F. Conteh
Summary: Liver transplant recipients are more likely to experience pregnancy-related complications such as miscarriage, intrauterine growth restriction, and hypertension, leading to higher costs and longer hospital stays. However, they have zero inpatient mortalities compared with the general population, indicating no increased risk of mortality during pregnancy.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Neurosciences
Flavio Maria Ceci, Giampiero Ferraguti, Carla Petrella, Antonio Greco, Massimo Ralli, Angela Iannitelli, Valentina Carito, Paola Tirassa, George N. Chaldakov, Marisa Patrizia Messina, Mauro Ceccanti, Marco Fiore
Summary: The nerve growth factor (NGF) is a member of the neurotrophic factor family, involved in the survival, differentiation, proliferation of neurons, as well as the regulation of immune and endocrine systems. Alcohol Use Disorders (AUD) caused by heavy drinking have negative effects on brain development and cognitive functions, and can lead to fetal alcohol spectrum disorders (FASD) when consumed during pregnancy.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Clinical Neurology
Namiko Kawamura, Ela Novianti, Nobuko Yamada-Goto, Riho Nakama, Akihiro Asakawa, Goro Katsuura, Akio Inui
Summary: The mesolimbic dopamine system plays a critical role in the rewarding and motivational aspects of consuming palatable food. Nicotinic receptors, particularly the alpha 7 subtype, have been found to suppress sucrose addiction in mice. Increasing sucrose concentrations lead to higher sucrose preference and intake in mice, with levels rising even after sucrose withdrawal.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Davidson, Peter Giacobbe, Tony P. George, Sean M. Nestor, Jennifer S. Rabin, Maged Goubran, Alexander J. Nyman, Anusha Baskaran, Ying Meng, Christopher B. Pople, Simon J. Graham, Fred Tam, Clement Hamani, Nir Lipsman
Summary: Alcohol use disorder (AUD) is a common and difficult-to-treat illness. Deep brain stimulation (DBS) in the nucleus accumbens (NAc) has shown potential in reducing alcohol-related symptoms. Clinical and imaging studies have found that NAc-DBS can lead to decreased metabolism in the NAc, reduced functional connectivity to other brain regions, and decreased activation in neural circuits related to alcohol cue-reactivity, resulting in improvements in AUD.
MOLECULAR PSYCHIATRY
(2022)
Article
Economics
Francis Mitrou, Ha Trong Nguyen, Huong Thu Le, Stephen R. Zubrick
Summary: This paper uses a fixed effects instrumental variables model and a nationally representative panel dataset from Australia to provide robust evidence on the causal impact of mental distress on cigarette smoking and alcohol drinking behaviors. The study finds that mental distress significantly increases the prevalence and intensity of both cigarette and alcohol consumption, and also significantly increases household monetary expenditures on tobacco and alcohol. These impacts are more pronounced among lower educated individuals or children of smokers, and slightly higher among males. The findings highlight the importance of mental health screening and treatment programs, especially among lower educated individuals or children of smokers, to prevent addictive behaviors.
EMPIRICAL ECONOMICS
(2023)
Article
Nutrition & Dietetics
Aitor Hernandez-Hernandez, David Oliver, Miguel Angel Martinez-Gonzalez, Miguel Ruiz-Canela, Sonia Eguaras, Estefania Toledo, Pedro Antonio de la Rosa, Maira Bes-Rastrollo, Alfredo Gea
Summary: Alcohol drinking patterns, especially adherence to the Mediterranean alcohol-drinking pattern, can affect the risk of hypertension. Low adherence to the Mediterranean alcohol-drinking pattern is associated with a higher incidence of hypertension, while high adherence is associated with a lower incidence.
Article
Psychiatry
Amanda Elton, J. Hunter Allen, Mya Yorke, Farhan Khan, Qiaosen Lin, Charlotte A. Boettiger
Summary: The study investigated the impact of family history on binge drinking among college students, finding that attentional ability plays a positive role in reducing binge drinking, especially among individuals with a family history. Interventions targeting attentional ability may help prevent binge drinking issues, particularly in high-risk populations with familial risk.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Public, Environmental & Occupational Health
Jirada Prasartpornsirichoke, Rasmon Kalayasiri, Polathep Vichitkunakorn, Woraphat Ratta-apha, Wanlop Atsariyasing, Natwarat Anekwit, Warot Lamyai, Chanchai Thongpanich, Surinporn Likhitsathian, Teerayuth Rungnirundorn, Wanida Rattanasumawong, Nawapat Chuatai, Sakol Srisuklorm, Athip Tanaree, Roengrudee Patanavanich
Summary: Parental supply of alcohol is associated with alcohol-related harms and severity of alcohol use disorder in Thai middle school students. Supply of alcohol from peers and siblings plays an important role in both outcomes. An increasing number of sources of alcohol supply increases the risk of alcohol-related harm and severity of alcohol use disorder.
Article
Neurosciences
Elizabeth V. Goldfarb, Dustin Scheinost, Nia Fogelman, Dongju Seo, Rajita Sinha
Summary: This study found that high-risk drinkers have adaptations in stress-related brain networks, which may serve as early markers of risky drinking behavior. The results also demonstrated the effectiveness of stress-predictive brain networks in prospectively predicting future loss of control over drinking.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Kevin R. Coffey, Vaishnavi Venkat, Mark O. West, David J. Barker
Summary: Neurons in the lateral preoptic area show varied responses to different components of drug self-administration. The majority of these neurons signal the operant response with increases in spiking activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
David E. Moorman, Morgan H. James, Ellen M. McGlinchey, Gary Aston-Jones
Article
Behavioral Sciences
Caitlin A. Orsini, David E. Moorman, Jared W. Young, Barry Setlow, Stan B. Floresco
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2015)
Article
Multidisciplinary Sciences
David E. Moorman, Gary Aston-Jones
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Neurosciences
David E. Moorman, Morgan H. James, Elisabeth A. Kilroy, Gary Aston-Jones
EUROPEAN JOURNAL OF NEUROSCIENCE
(2016)
Article
Statistics & Probability
Bo Zhou, David E. Moorman, Sam Behseta, Hernando Ombao, Babak Shahbaba
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2016)
Article
Computer Science, Artificial Intelligence
Babak Shahbaba, Bo Zhou, Shiwei Lan, Hernando Ombao, David Moorman, Sam Behseta
NEURAL COMPUTATION
(2014)
Article
Multidisciplinary Sciences
Elena M. Vazey, David E. Moorman, Gary Aston-Jones
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Neurosciences
Ifeyinwa Arinze, David E. Moorman
Article
Substance Abuse
John S. Hernandez, Annalise N. Binette, Taryn Rahman, Jeffrey D. Tarantino, David E. Moorman
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Neurosciences
David E. Moorman, Gary Aston-Jones
Summary: The prefrontal cortex plays a critical role in the execution and inhibition of reward seeking. This study investigates the neural activity in different subregions of the medial prefrontal cortex (PL and IL) during various stages of cocaine seeking. The results reveal complex functions and contributions of both PL and IL regions to drug seeking and addiction.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Jessica P. Caballero, Garrett B. Scarpa, Luke Remage-Healey, David E. Moorman
Article
Neurosciences
Debra A. Bercovici, Oren Princz-Lebel, Maric T. Tse, David E. Moorman, Stan B. Floresco
Article
Substance Abuse
Ellen M. Rodberg, Carolina R. den Hartog, Rachel I. Anderson, Howard C. Becker, David E. Moorman, Elena M. Vazey
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2017)
Article
Neurosciences
David E. Moorman, Morgan H. James, Elisabeth A. Kilroy, Gary Aston-Jones
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.