Article
Biochemistry & Molecular Biology
Giulia Righetti, Melanie Kempf, Christoph Braun, Ronja Jung, Susanne Kohl, Bernd Wissinger, Eberhart Zrenner, Katarina Stingl, Krunoslav Stingl
Summary: By characterizing the time-frequency representation of OPs in ACHM individuals and controls, this study found a significantly reduced relative power in ACHM individuals compared to controls, particularly in the time-frequency window >100 Hz. This suggests that the activity of OPs above 100 Hz in ACHM individuals is mainly driven by cones rather than rods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Thermodynamics
Yibing Hu, Ling Xu, Weihui Liang
Summary: High population density in dormitories can lead to physical and mental issues for occupants exposed to volatile organic compounds (VOCs). Ensuring good indoor air quality (IAQ) is crucial. This study measured VOC concentrations in 10 dormitories and analyzed the contribution of building materials and human-related emissions. Sensory evaluation of indoor odor was used as a supplementary method for IAQ assessment. The results showed that odor intensity-OAV better characterized the correlation between subjective and objective factors compared to VOC concentration. However, Weber-Fencher's law had limitations in characterizing this correlation in indoor air mixtures.
BUILDING SIMULATION
(2023)
Article
Computer Science, Interdisciplinary Applications
Yanchuang Cao, Jun Liu, Dawei Chen
Summary: This work presents an explicitly-sparse representation for oscillatory kernels. It develops a wave atom based method to construct multilevel wave atom-like functions as a transform of the original nodal basis. The resulting system matrix is explicitly-sparse and computed explicitly, with further enhancement of sparsity via a-posteriori compression. Numerical results demonstrate the log-linear computational complexity with controllable accuracy. This representation is expected to lay ground to future work related to fast direct solvers and effective preconditioners for high frequency problems.
JOURNAL OF COMPUTATIONAL PHYSICS
(2024)
Article
Engineering, Electrical & Electronic
Yang Liu, Jigou Liu, Ralph Kennel
Summary: The cross-correlation spectrum is introduced as a new frequency measurement method, providing better denoising and independently adjustable frequency and time resolutions. The method shows excellent performance in simulations and can be applied to various signal conditions and application environments.
Article
Clinical Neurology
Marko Mijic, Benedikt Schoser, Peter Young
Summary: This study investigates the changes in SEPs caused by an acute stroke after 2 weeks of rehabilitation with FES and the correlation between SEPs and the efficacy of FES against FD stroke symptoms. The results show that FES intervention can modify pathological gait and improve SEP afferent feedback.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
A. Kurgansky, D. Lomakin, A. A. Korneev, R. Machinskaya
Summary: This study investigates the impact of trajectory presentation mode and duration of representation retention in working memory on evoked potentials. The results show that the amplitude of N100 is significantly higher in the static presentation mode compared to dynamic mode, independent of delay. However, the amplitude of other components is not affected by the presentation mode but is influenced by delay. The study also discusses the involvement of different visual sensory-specific areas in holding the representation of the broken line and the transformation of this representation from sensory-specific to abstract format.
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
V. Bozhokim Sergey, B. Suslova Irina
Summary: The study proposes a model for spectral-temporal analysis of irregular processes by treating complex non-stationary signals as superposition of elementary non-stationary signals. It is found that the superposition of elementary non-stationary signals can effectively simulate complex signals.
PROCEEDINGS OF 2021 2ND INTERNATIONAL CONFERENCE ON ARTIFICIAL INTELLIGENCE AND INFORMATION SYSTEMS (ICAIIS '21)
(2021)
Article
Biochemistry & Molecular Biology
Takaaki Sato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Neurosciences
Nobuo Kunori, Ichiro Takashima
Article
Chemistry, Physical
Nur Aima Hafiza Shazali, Noorzaileen Eileena Zaidi, Hidayah Ariffin, Luqman Chuah Abdullah, Ferial Ghaemi, Jafri Malin Abdullah, Ichiro Takashima, Nik Mohd Afizan Nik Abd Rahman
Article
Neurosciences
Kazuaki Nagasaka, Ichiro Takashima, Keiji Matsuda, Noriyuki Higo
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Mutsumi Matsukawa, Narumi Katsuyama, Masato Imada, Shin Aizawa, Takaaki Sato
Article
Neurosciences
Shinnosuke Dezawa, Kazuaki Nagasaka, Yumiko Watanabe, Ichiro Takashima
Summary: A study using immunotoxin to induce lesions in rats found a positive correlation between survival rate of NBM cholinergic neurons and tactile hypersensitivity. The loss of neurons in NBM diminishes acetylcholine actions in S1, enhancing the cortical representation of sensory stimuli and potentially leading to behavioral hypersensitivity.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Nobuo Kunori, Ichiro Takashima
Summary: The study found that transcranial direct current stimulation can improve cortico-cortical neuronal transmission from M1 to M2 in rats, affecting synaptic inputs in both superficial and deep layers of M2.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Junpei Kato, Yumi Murata, Ichiro Takashima, Noriyuki Higo
Summary: Using a macaque model, researchers quantitatively investigated changes in macrophages and microglia after focal infarction of the internal capsule. They found that Iba1-positive MO/MG gradually increased in the periinfarct core, lasting at least 6 months, and also observed retrograde atrophy of neurons in layer V of the primary motor cortex. The study suggests that MO/MG activation plays an anti-inflammatory role both in the periinfarct core and in the primary motor cortex.
NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Mizuho Gotoh, Kazuaki Nagasaka, Mariko Nakata, Ichiro Takashima, Shinya Yamamoto
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Kazuaki Nagasaka, Kiyotaka Nemoto, Ichiro Takashima, Daigo Bando, Keiji Matsuda, Noriyuki Higo
Summary: Central post-stroke pain (CPSP) is a chronic pain condition caused by stroke lesions of somatosensory pathways, with maladaptive plasticity of pain-related brain regions potentially playing a key role in its pathophysiology. Research using a CPSP monkey model revealed that progressive changes in neuronal morphology, including synaptic loss in the ipsilesional posterior insular cortex/secondary somatosensory cortex, may be implicated in CPSP.
Article
Neurosciences
Ichiro Takashima, Riichi Kajiwara
Summary: Functional magnetic resonance imaging studies assume linear relationships between hemodynamic responses and neural activity, but investigating the neurovascular transfer function accurately requires full-field imaging of electrophysiological and hemodynamic responses with optical imaging tools like VSD and IS. Results from optical imaging in rat somatosensory cortices showed differences in sensory responses between S1 and S2, with more localized neural activity in S1 and stronger metabolic responses in S1 compared to S2. Despite these differences, the neurovascular coupling did not vary between the S1 and S2 cortices.
Review
Behavioral Sciences
Takaaki Sato, Mutsumi Matsukawa, Toshio Iijima, Yoichi Mizutani
Summary: Odors can trigger various emotional responses, and olfaction shares common features with color vision. Odors are likely perceived as multiple elemental odors hierarchically.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Mutsumi Matsukawa, Masaaki Yoshikawa, Narumi Katsuyama, Shin Aizawa, Takaaki Sato
Summary: Rodents have a greater variety of olfactory receptors, allowing them to acquire more information from smell than humans. They react instinctively to predator odors even without prior exposure, and these odors have been used in models of neuropsychiatric disorders. This review focuses on the role of inhibitory neural circuits in the anterior piriform cortex (APC) and discusses the changes in these circuits following innate reactions to odor exposure. The potential therapeutic application of odors in the treatment of stress-related disorders is also discussed.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Anesthesiology
Kazuaki Nagasaka, Ichiro Takashima, Keiji Matsuda, Noriyuki Higo
Summary: In this study, using a macaque model, the researchers found that inactivating the posterior insular cortex (PIC) and secondary somatosensory cortex (SII) can reduce hypersensitivity to thermal stimuli, indicating the potential therapeutic approach for thermal hyperalgesia in central post-stroke pain (CPSP).
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Behavioral Sciences
Yumiko Watanabe, Shinnosuke Dezawa, Hiroyuki Takei, Kazuaki Nagasaka, Ichiro Takashima
Summary: By studying rats, researchers found that combining transcranial direct current stimulation (tDCS) of the prefrontal cortex with hippocampal activation can promote neuronal plasticity and improve cognitive and memory functions. This new treatment method has the potential to be used in the treatment of psychiatric and neurodegenerative disorders.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.