Article
Peripheral Vascular Disease
Theodore S. Kalbfleisch, Nahla A. Hussien A. AbouEl Ela, Kai Li, Wesley A. Brashear, Kelli J. Kochan, Andrew E. Hillhouse, Yaming Zhu, Isha S. Dhande, Eric J. Kline, Elizabeth A. Hudson, Terence D. Murphy, Francoise Thibaud-Nissen, Melissa L. Smith, Peter A. Doris
Summary: We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, which is a widely used model for studying human cardiovascular disease. The assembly was assembled from long read sequencing data and scaffolded with long-range structural information. The results show that the assembly is comparable in contiguity and completeness to the current rat reference assembly, and the use of HiFi sequencing improves the accuracy at the single base level. The generated transcript sequence reads were used to validate the coding assembly and annotate the assembly with RNA transcripts.
Article
Cell Biology
Shinsuke Nakagawa, Hiroki Ohara, Masami Niwa, Kazuo Yamagata, Toru Nabika
Summary: This study examines the role of brain capillary endothelial cells (BECs), astrocytes, and pericytes in the blood-brain barrier (BBB) dysfunction in stroke-prone spontaneously hypertensive rats (SHRSP). In vitro BBB models were constructed using different combinations of cells. The results showed that SHRSP BECs had lower barrier function, SHRSP astrocytes impaired the ability to induce barrier function in BECs, and both SHRSP and Wistar Kyoto astrocytes and pericytes could potentiate the barrier function of BECs. Defective interaction among BBB cells, especially BECs and astrocytes, was found to be responsible for the functional disorder of BBB in SHRSP.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Food Science & Technology
Ying Li, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia, Hong-Bao Li, Yu-Ming Kang
Summary: The study reveals that Vitamin C can reduce elevated blood pressure in hypertensive animals by improving the diversity and abundance of gut microbiota, as well as enhancing gut pathology and integrity while reducing inflammatory responses and oxidative stress in the hypothalamus paraventricular nucleus.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Davi J. A. Moraes, Melina P. da Silva, Daniel P. de Souza, Viviane Felintro, Julian F. R. Paton
Summary: In hypertension, the carotid body chemoreceptors are hyperactive and contribute to bronchoconstriction. Denervation of the carotid body can reduce bronchoconstrictor tone, while stimulation of the carotid body enhances chemoreflex-induced bronchoconstriction. These findings suggest that the carotid body plays a significant role in modulating bronchoconstriction in hypertensive individuals.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Hong-Bao Li, Meng-Lu Xu, Meng-Meng Du, Xiao-Jing Yu, Juan Bai, Wen-Jie Xia, Zhi-Ming Dai, Chang-Xing Li, Ying Li, Qing Su, Xiao-Min Wang, Yuan-Yuan Dong, Yu-Ming Kang
Summary: This study demonstrated that curcumin can reshape the gut microbiota composition, increase butyrate levels, reduce neuroinflammation and oxidative stress, activate GPR 43, and improve gut-brain communication dysregulation to induce antihypertensive effects.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maurizio Forte, Simona Marchitti, Maria Cotugno, Flavio Di Nonno, Rosita Stanzione, Franca Bianchi, Leonardo Schirone, Sonia Schiavon, Daniele Vecchio, Gianmarco Sarto, Mariarosaria Scioli, Salvatore Raffa, Giuliano Tocci, Michela Relucenti, Maria Rosaria Torrisi, Valentina Valenti, Francesco Versaci, Carmine Vecchione, Massimo Volpe, Giacomo Frati, Speranza Rubattu, Sebastiano Sciarretta
Summary: The study demonstrated that trehalose (TRE) could reduce the occurrence of stroke and renal damage in stroke-prone spontaneously hypertensive rats (SHRSP) fed with high salt diet, as well as decrease systolic blood pressure. It also showed beneficial effects on the vascular function of high salt-fed SHRSP, restoring brain autophagy and reducing mitochondrial mass.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Koji Kawabeta, Masahiro Yuasa, Michihiro Sugano, Kazunori Koba
Summary: Dietary beta-conglycinin has been shown to lower blood pressure in spontaneously hypertensive rats by increasing plasma adiponectin concentration and possibly regulating the renin-angiotensin system.
Article
Biochemistry & Molecular Biology
Nan Wu, Fen Zheng, Na Li, Ying Han, Xiao-Qing Xiong, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ye-Bo Zhou
Summary: The study revealed that RND3 plays critical roles in attenuating superoxide production, vascular smooth muscle cells migration and proliferation, and vascular remodeling in hypertension by inhibiting ROCK1-NOX1/2 and mitochondria superoxide signaling.
Article
Geriatrics & Gerontology
Yu Gao, Changhong Ren, Xiaohua Li, Wantong Yu, Sijie Li, Haiyan Li, Yan Wang, Dong Li, Ming Ren, Xunming Ji
Summary: Vascular remodeling is an initial step in the development of hypertension, and limb remote ischemic conditioning (LRIC) has shown promising effects on ameliorating blood pressure and vascular remodeling through inflammation regulation in animal models and patients with prehypertension and early-stage hypertension. The study suggests that long-term LRIC treatment may be a potential preventive approach for individuals with elevated blood pressure or prehypertension.
Article
Physiology
Isha S. Dhande, Yaming Zhu, Aniket S. Joshi, M. John Hicks, Michael C. Braun, Peter A. Doris
Summary: In this study, an immunoglobulin knockout was generated in the susceptible animal model of hypertensive renal disease (SHR-A3), and it was found that immunoglobulin plays a pathogenic role in hypertensive renal injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Physiology
Chao Ye, Fen Zheng, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Summary: Excessive sympathetic activation plays a crucial role in the pathogenesis of hypertension. The study found that the renal stimulation enhances sympathetic activity, contributing to the development of hypertension. The excitation of renal reflex is enhanced in the early stage of hypertension and attenuated in the later stage of hypertension in SHR, indicating the involvement of abnormal ERR in the development of hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Karli Mockenhaupt, Katarzyna M. Tyc, Adam McQuiston, Alexandra K. Gonsiewski, Masoumeh Zarei-Kheirabadi, Avani Hariprashad, Debolina D. Biswas, Angela S. Gupta, Amy L. Olex, Sandeep K. Singh, Michael R. Waters, Jeff L. Dupree, Mikhail G. Dozmorov, Tomasz Kordula
Summary: The transcription factor YY1 is expressed in astrocytes and plays a critical role in regulating gene expression and maturation of cerebellar astrocytes. It is also necessary for maintaining the mature phenotype of astrocytes in the adult cerebellum.
Article
Biochemistry & Molecular Biology
Kanako Matsuoka, Hidenori Akaihata, Junya Hata, Ryo Tanji, Ruriko Honda-Takinami, Akifumi Onagi, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojima
Summary: This study evaluated the effects of orally administered l-theanine in spontaneously hypertensive rats with bladder dysfunction induced by chronic sympathetic hyperactivity. The results showed that l-theanine significantly decreased sympathetic nervous system activity, increased bladder capacity, and improved bladder contractility, suggesting its potential in preventing bladder dysfunction caused by chronic sympathetic hyperactivity.
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Myeongjoo Son, Seyeon Oh, Junwon Choi, Ji Tae Jang, Kuk Hui Son, Kyunghee Byun
Summary: The study found that Ecklonia cava extracts (ECE) and dieckol (DK) can reduce the levels of Ang II and expression of AT1R/TGF beta/SMAD in spontaneously hypertensive rats (SHRs), leading to decreased EMT and renal fibrosis, ultimately restoring renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yugandhar V. Gowrisankar, Michelle A. Clark
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Cell Biology
Yugandhar V. Gowrisankar, Michelle A. Clark
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Vudhya G. Yugandhar, Michelle A. Clark
Article
Biochemistry & Molecular Biology
You-Cheng Hseu, Hsin-Ju Cho, Yugandhar Vudhya Gowrisankar, Varadharajan Thiyagarajan, Xuan-Zao Chen, Kai-Yuan Lin, Hui-Chi Huang, Hsin-Ling Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Cell Biology
You-Cheng Hseu, Chih-Ting Chang, Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen, Hui-Chang Lin, Hung-Rong Yen, Hsin-Ling Yang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
You-Cheng Hseu, Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen, Yi-Chen Yang, Hsin-Ling Yang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
You-Cheng Hseu, Xuan-Zao Chen, Yugandhar Vudhya Gowrisankar, Hung-Rong Yen, Jing-Yuan Chuang, Hsin-Ling Yang
Article
Cell Biology
Hsin-Ling Yang, Ting-Yu Yang, Yugandhar Vudhya Gowrisankar, Chun-Huei Liao, Jiunn-Wang Liao, Pei-Jane Huang, You-Cheng Hseu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Pharmacology & Pharmacy
Hsin-Ling Yang, Chia-Pei Lin, Yugandhar Vudhya Gowrisankar, Pei-Jane Huang, Wan-Lin Chang, Sirjana Shrestha, You-Cheng Hseu
Summary: Ellagic acid inhibits melanogenesis by inducing autophagy, suppressing tyrosinase activity, and affecting Nrf2 and ?-MSH pathways.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yugandhar Vudhya Gowrisankar, Sunitha Manne Mudhu, Santhosh Kumar Pasupuleti, Subbarayudu Suthi, Abhijit Chaudhury, Potukuchi Venkata Gurunadha Krishna Sarma
Summary: The spread of Staphylococcus aureus infections through biofilms is a major concern in hospital-acquired infections, with biofilm formation facilitated by glutamine biosynthesis playing a crucial role. Research has shown that multidrug-resistant strains of S. aureus exhibit higher biofilm units and glutamine synthetase activity.
CANADIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Oncology
Hsin-Ling Yang, Ya-Ting Kuo, Yugandhar Vudhya Gowrisankar, Kai-Yuan Lin, Li-Sung Hsu, Pei-Jane Huang, Hui-Chang Lin, You-Cheng Hseu
INTEGRATIVE CANCER THERAPIES
(2020)
Article
Biotechnology & Applied Microbiology
O. Hari Prasad, V. Nagarjuna, Ch Lakshmi Prasanna, D. Vasu, V. G. Yugandhar, U. Venkatesh Prasad, P. V. L. N. Srinivas Rao, Abhijit Chaudhary, O. V. S. Reddy, P. V. G. K. Sarma
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2010)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.