Article
Cell Biology
Jing Zhang, Xia Cai, Qin Zhang, Xiaozhong Li, Siyuan Li, Jianyong Ma, Wengen Zhu, Xiao Liu, Meilin Wei, Wei Tu, Yunfeng Shen, Jianping Liu, Xiaoyang Lai, Peng Yu
Summary: The study found that hydrogen sulfide can restore the cardioprotection induced by sevoflurane postconditioning in diabetic rats by enhancing and promoting the SIRT1/Nrf2 signaling pathway, thereby mediating mitochondrial dysfunction and oxidative stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Neurosciences
Naixin Liu, Yilin Li, Ying Yang, Longjun Shu, Yixiang Liu, Yutong Wu, Dandan Sun, Zijian Kang, Yue Zhang, Dan Ni, Ziqi Wei, Shanshan Li, Meifeng Yang, Ying Wang, Jun Sun, Xinwang Yang
Summary: In this study, a novel neuroprotective peptide OL-FS13 was identified from the odorous frog species Odorrana livida, showing significant improvement in cerebral ischemia-reperfusion injury and providing a new drug candidate for clinical treatment.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Zhan Zhuo, Huimei Wang, Shuai Zhang, Perry F. Bartlett, Tara L. Walker, Sheng-Tao Hou
Summary: Despite progress in reperfusion therapy, functional recovery after stroke remains suboptimal. Selenium is emerging as a promising therapeutic agent for stroke, but its long-term effects and mechanisms of action are not well understood. This study demonstrates that selenium treatment in a mouse model of stroke has long-term neuroprotective effects and reduces cerebral infarction, oxidative stress, and ferroptosis. Selenium supplementation also improves motor performance and reverses stroke-induced gut dysbiosis. These findings highlight the multifaceted and clinical potential of selenium in stroke treatment.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Zhu Wang, Jie Wang, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury is a phenomenon characterized by restricting blood supply to organs followed by restoring blood flow and oxygenation, leading to various diseases. Autophagy, an important cellular pathway, plays a key role in maintaining cellular balance and participating in both physiological and pathological processes. Hydrogen sulfide (H2S) is a significant gas signal molecule that, along with carbon monoxide (CO) and nitric oxide (NO), regulates a range of physiological and pathological processes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Yun Wang, Zhe Dong, Zongze Zhang, Yanlin Wang, Kun Yang, Xinyi Li
Summary: The study demonstrates that irisin postconditioning protects against lung ischemia/reperfusion (I/R) damage by inhibiting ferroptosis through the activation of the Nrf2/HO-1 signaling axis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Hyun Seok Hwang, Aida Rahimi Kahmini, Julia Prascak, Alexis Cejas-Carbonell, Isela C. Valera, Samantha Champion, Mikayla Corrigan, Florence Mumbi, Michelle S. Parvatiyar
Summary: This study investigated the role of sarcospan (SSPN) in the cardiac response to acute ischemia-reperfusion (IR) injury. The findings suggested that SSPN deficiency in mice leads to increased infarct size and arrhythmia susceptibility post-IR injury. Additionally, SSPN depletion resulted in decreased Ca2+ handling capacity and increased oxidative stress pathways in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Yushi Wu, Haiqiong Liu, Xianbao Wang
Summary: Acute myocardial infarction requires timely reperfusion to reduce myocardial damage, but reperfusion may lead to myocardial ischemia/reperfusion injury. Pharmacological postconditioning is an effective and flexible strategy to reduce myocardial injury by administering medication before or during early reperfusion.
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
Summary: The study suggests that NMN administration offers protection against retinal ischemia/reperfusion injury by suppressing inflammation, protecting retinal neuronal cells, and activating the antioxidant pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Longfei Wu, Ming Wei, Bohao Zhang, Bowei Zhang, Jian Chen, Sifei Wang, Leilei Luo, Shuling Liu, Sijie Li, Changhong Ren, David C. Hess, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study investigated the safety and tolerability of direct ischemic postconditioning (IPostC) in both a dog model and patients with acute ischemic stroke treated with thrombectomy, and found it to be safe, feasible, and tolerable.
Article
Immunology
Qing Yang, Zhen-zhen Zhao, Jian Xie, Yun-peng Wang, Kai Yang, Yu Guo, Jia-feng Wang, Xiao-ming Deng
Summary: The study found that the optimal dose of SEI in treating liver I/R injury was 200 mg/kg. SEI administration reduced ALT, AST, and histopathological injury in I/R liver, similar to GSH. SEI treatment decreased TNF-alpha, IL-113, and IL-6 in liver I/R mice, and inhibited phosphorylation of p65 NF-Kappa B and MAPK kinases in liver tissues. SEI also showed antioxidative, anti-inflammatory, and anti-apoptotic effects in both in vivo and in vitro experiments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Immunology
Yahong Fu, Junxian Gao, Yanqing Li, Xi Yang, Yun Zhang
Summary: This study demonstrates the significant role of tripartite motif-containing protein 21 (TRIM21) in cerebral ischemia/reperfusion injury. Inhibition of TRIM21 can alleviate the damage to neurons caused by oxygen-glucose deprivation/reoxygenation (OGD/R). This protective effect may be achieved by regulating the Keap1/Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefanie Scheid, Max Goeller, Wolfgang Baar, Jakob Wollborn, Hartmut Buerkle, Gunther Schlunck, Wolf Lagreze, Ulrich Goebel, Felix Ulbrich
Summary: Experimental results confirm that inhaled H2S at appropriate concentrations can exert neuroprotective effects in rat retinal ischemia-reperfusion injury, reducing cell apoptosis and inflammation. H2S treatment modulates NF-kappa B activation and is expected to alleviate inflammation after retinal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu
Summary: This study investigates the role of Gomisin J in cerebral ischemia-reperfusion injury and finds that it has anti-apoptotic, antioxidant, and anti-inflammatory effects, reducing the severity of the injury.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.