Parallels between wound healing, epimorphic regeneration and solid tumors

Blastemal progenitors modulate immune signaling during early limb regeneration

(2019) Stephanie L. Tsai et al.   DEVELOPMENT

Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells

(2019) Dimuthu K. Wasgewatte Wijesinghe et al.   Skeletal Muscle

Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression

(2019) Pieter Goossens et al.   Cell Metabolism

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

(2019) Christopher J. Halbrook et al.   Cell Metabolism

A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration

(2019) Soumyashree Das et al.   CELL

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer

(2019) Johanna Wagner et al.   CELL

Innate immune cell–epithelial crosstalk during wound repair

(2019) Jennifer C. Brazil et al.   JOURNAL OF CLINICAL INVESTIGATION

The emerging role of the piRNA/piwi complex in cancer

(2019) Yongmei Liu et al.   Molecular Cancer

Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration

(2019) Titta Novianti et al.   Organogenesis

Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

(2019) Sruthi Purushothaman et al.   eLife

Prospectively Isolated Tetraspanin + Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

(2018) An Zeng et al.   CELL

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

(2018) Charissa Kim et al.   CELL

The blastema and epimorphic regeneration in mammals

(2018) Ashley W. Seifert et al.   DEVELOPMENTAL BIOLOGY

Systemic cell cycle activation is induced following complex tissue injury in axolotl

(2018) Kimberly Johnson et al.   DEVELOPMENTAL BIOLOGY

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

(2018) Jordan A. Krall et al.   Science Translational Medicine

IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization

(2018) Zafira Castaño et al.   NATURE CELL BIOLOGY

Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration

(2018) Tobias Gerber et al.   SCIENCE

Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration

(2018) Mailyn A. Nishiguchi et al.   Cell Reports

Piwi-interacting RNAs (piRNAs) and cancer: Emerging biological concepts and potential clinical implications

(2018) Wenhao Weng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Cellular and Molecular Basis for Planarian Regeneration

(2018) Peter W. Reddien   CELL

Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

(2018) Vincent Bernard et al.   CLINICAL CANCER RESEARCH

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

(2018) Themistoklis M. Tsarouchas et al.   Nature Communications

Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution

(2018) Nicholas D. Leigh et al.   Nature Communications

TNF signaling and macrophages govern fin regeneration in zebrafish larvae

(2017) Mai Nguyen-Chi et al.   Cell Death & Disease

HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into G Alert

(2017) Joseph T. Rodgers et al.   Cell Reports

Macrophages are necessary for epimorphic regeneration in African spiny mice

(2017) Jennifer Simkin et al.   eLife

Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity

(2017) Stéphane Terry et al.   Frontiers in Immunology

Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment

(2017) Benjamin Owusu et al.   Cancers

CXCL12 and osteopontin from bone marrow-derived mesenchymal stromal cells improve muscle regeneration

(2017) Yasushi Maeda et al.   Scientific Reports

The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration

(2017) Jennifer Munkley et al.   Scientific Reports

Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools

(2016) Joshua D. Currie et al.   DEVELOPMENTAL CELL

Intra-tumour heterogeneity - going beyond genetics

(2016) Francisco Caiado et al.   FEBS Journal

CAFs and TAMs: maestros of the tumour microenvironment

(2016) Yoshihiro Komohara et al.   JOURNAL OF PATHOLOGY

Dissecting the genetics of complex traits using summary association statistics

(2016) Bogdan Pasaniuc et al.   NATURE REVIEWS GENETICS

Cancer heterogeneity is not compatible with one unique cancer cell metabolic map

(2016) A Strickaert et al.   ONCOGENE

Fast revascularization of the injured area is essential to support zebrafish heart regeneration

(2016) Rubén Marín-Juez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Tetraspanin CD151 as an emerging potential poor prognostic factor across solid tumors: a systematic review and meta-analysis

(2016) Ping Zeng et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes

(2015) M. Robertson-Tessi et al.   CANCER RESEARCH

LINE-1 in cancer: multifaceted functions and potential clinical implications

(2015) Lu Xiao-Jie et al.   GENETICS IN MEDICINE

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tetraspanin 1 is involved in survival, proliferation and carcinogenesis of pancreatic cancer

(2015) FENG-QIANG HOU et al.   ONCOLOGY REPORTS

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy

(2015) Nozomi Hayashiji et al.   Nature Communications

Identification of polarized macrophage subsets in zebrafish

(2015) Mai Nguyen-Chi et al.   eLife

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

Angiotensin II inhibitor facilitates epidermal wound regeneration in diabetic mice

(2015) Maria Kamber et al.   Frontiers in Physiology

FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration

(2015) Alessandra Castiglioni et al.   PLoS One

Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl

(2014) D. Lopez et al.   BLOOD

Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15

(2014) F. Bruzzese et al.   CANCER RESEARCH

Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance--Implications for IGF-II and IGF-IR-Targeted Therapy

(2014) B. Li et al.   CLINICAL CANCER RESEARCH

Macrophages modulate adult zebrafish tail fin regeneration

(2014) T. A. Petrie et al.   DEVELOPMENT

Scar-free wound healing and regeneration in amphibians: Immunological influences on regenerative success

(2014) James W. Godwin et al.   DIFFERENTIATION

Endogenous Bone Regeneration Is Dependent Upon a Dynamic Oxygen Event

(2014) Mimi C Sammarco et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tetraspanins at a glance

(2014) S. Charrin et al.   JOURNAL OF CELL SCIENCE

Gcsf-Chr19 Promotes Neutrophil Migration to Damaged Tissue through Blood Vessels in Zebrafish

(2014) J. A. Galdames et al.   JOURNAL OF IMMUNOLOGY

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

(2014) Joseph T. Rodgers et al.   NATURE

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Innate immune system and tissue regeneration in planarians: An area ripe for exploration

(2014) T. Harshani Peiris et al.   SEMINARS IN IMMUNOLOGY

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea

(2014) M. Lucila Scimone et al.   Stem Cell Reports

Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation

(2013) Konstantin Knoblich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of TGFβ signaling during tail regeneration in the leopard Gecko (Eublepharis macularius)

(2013) Richard W.D. Gilbert et al.   DEVELOPMENTAL DYNAMICS

Angiotensin II Drives the Production of Tumor-Promoting Macrophages

(2013) Virna Cortez-Retamozo et al.   IMMUNITY

Tetraspanin 1 promotes invasiveness of cervical cancer cells

(2013) SEBASTIAN HÖLTERS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Angiotensin II Inhibits Satellite Cell Proliferation and Prevents Skeletal Muscle Regeneration

(2013) Tadashi Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration

(2013) Ying Huang et al.   PLoS One

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

The regenerative capacity of the zebrafish heart is dependent on TGF  signaling

(2012) F. Chablais et al.   DEVELOPMENT

Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration

(2012) Wei Zhu et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Activation of germline-specific genes is required for limb regeneration in the Mexican axolotl

(2012) Wei Zhu et al.   DEVELOPMENTAL BIOLOGY

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Tetraspanin CD151 plays a key role in skin squamous cell carcinoma

(2012) Q Li et al.   ONCOGENE

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

Identification of Luminal Breast Cancers That Establish a Tumor-Supportive Macroenvironment Defined by Proangiogenic Platelets and Bone Marrow-Derived Cells

(2012) H. S. Kuznetsov et al.   Cancer Discovery

Instruction of myeloid cells by the tumor microenvironment: Open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations

(2012) Elio Schouppe et al.   OncoImmunology

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

(2011) Lopamudra Das Roy et al.   BMC CANCER

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

(2011) Yanique I. Rattigan et al.   EXPERIMENTAL CELL RESEARCH

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

(2011) Moshe Elkabets et al.   JOURNAL OF CLINICAL INVESTIGATION

G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation

(2011) Mie Hara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatocyte growth factor twenty years on: Much more than a growth factor

(2011) Takahiro Nakamura et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Regenerative phenotype in mice with a point mutation in transforming growth factor   type I receptor (TGFBR1)

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration

(2011) D. E. Wagner et al.   SCIENCE

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Planarian regeneration involves distinct stem cell responses to wounds and tissue absence

(2010) Danielle Wenemoser et al.   DEVELOPMENTAL BIOLOGY

The Role of Tumor Stroma in Cancer Progression and Prognosis: Emphasis on Carcinoma-Associated Fibroblasts and Non-small Cell Lung Cancer

(2010) Roy M. Bremnes et al.   Journal of Thoracic Oncology

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

High-Density Gene Expression Analysis of Tumor-Associated Macrophages from Mouse Mammary Tumors

(2009) Laureen S. Ojalvo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cells keep a memory of their tissue origin during axolotl limb regeneration

(2009) Martin Kragl et al.   NATURE

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1

(2009) S.-Y. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression

(2009) Dingcheng Gao et al.   TRENDS IN MOLECULAR MEDICINE

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL