Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment

Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation

(2017) Benjamin Y. Owusu et al.   Oncotarget

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody

(2016) E. Pupo et al.   CANCER RESEARCH

Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer

(2016) F. Xing et al.   CANCER RESEARCH

α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer

(2016) Zhenfu Han et al.   ChemMedChem

MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells

(2016) Francesca De Bacco et al.   EMBO Molecular Medicine

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI–Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation

(2016) Toshimitsu Yamaoka et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling

(2016) Benjamin Y. Owusu et al.   Oncotarget

Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer

(2016) Kathryn E. Ware et al.   Oncotarget

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

The Efficacy and Risk Profile of c-Met inhibitors in Non-small Cell Lung Cancer: a Meta-analysis

(2016) Sa Ye et al.   Scientific Reports

Genomic Instability Causes HGF Gene Activation in Colon Cancer Cells, Promoting Their Resistance to Necroptosis

(2015) Danushka Seneviratne et al.   GASTROENTEROLOGY

Epithelial-mesenchymal transition and drug resistance in breast cancer (Review)

(2015) JING HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

(2015) Charles K. Pallangyo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

(2015) Alexandre Calon et al.   NATURE GENETICS

Stromal contribution to the colorectal cancer transcriptome

(2015) Claudio Isella et al.   NATURE GENETICS

Toward understanding and exploiting tumor heterogeneity

(2015) Ash A Alizadeh et al.   NATURE MEDICINE

Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation

(2015) Phanindra K. M. Venukadasula et al.   ACS Medicinal Chemistry Letters

Hepatocyte growth factor increases the invasive potential of PC-3 human prostate cancer cells via an ERK/MAPK and Zeb-1 signaling pathway

(2015) YILI HAN et al.   Oncology Letters

Pharmacologic targeting of the PI3K/mTOR pathway controls release of angioregulators from primary human acute myeloid leukemia cells and their neighboring stromal cells

(2015) Håkon Reikvam et al.   Oncotarget

Serum levels of hepatocyte growth factor and epiregulin are associated with the prognosis on anti-EGFR antibody treatment in KRAS wild-type metastatic colorectal cancer

(2014) N Takahashi et al.   BRITISH JOURNAL OF CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs

(2014) S. Pennacchietti et al.   CANCER RESEARCH

Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas

(2014) S. Sun et al.   CANCER RESEARCH

MET Signaling in Colon Cancer Stem-like Cells Blunts the Therapeutic Response to EGFR Inhibitors

(2014) Paolo Luraghi et al.   CANCER RESEARCH

Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR–ERK independent of epithelial–mesenchymal transition

(2014) Yan Jiang et al.   Journal of Molecular Cell Biology

Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer

(2014) Zhenfu Han et al.   ACS Medicinal Chemistry Letters

Mechanisms of Hepatocyte Growth Factor Activation in Cancer Tissues

(2014) Makiko Kawaguchi et al.   Cancers

Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion

(2013) Elzbieta A. Swietlicki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Suppressor of Intestinal Tumorigenesis

(2013) S. Hoshiko et al.   CANCER RESEARCH

The MET Oncogene in Glioblastoma Stem Cells: Implications as a Diagnostic Marker and a Therapeutic Target

(2013) C. Boccaccio et al.   CANCER RESEARCH

Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model

(2013) Jingjia Ye et al.   CANCER SCIENCE

Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery

(2013) Michael P. Lisanti et al.   CELL CYCLE

Strengthening Context-Dependent Anticancer Effects on Non-Small Cell Lung Carcinoma by Inhibition of Both MET and EGFR

(2013) Y.-W. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology

(2013) S Ogino et al.   ONCOGENE

Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion

(2013) Chang-Chang Jia et al.   PLoS One

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

(2013) Alberto Bardelli et al.   Cancer Discovery

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis

(2012) Vasiliki Koliaraki et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

(2012) Alex Kentsis et al.   NATURE MEDICINE

Activating Mutations in β-Catenin in Colon Cancer Cells Alter Their Interaction with Macrophages; the Role of Snail

(2012) Pawan Kaler et al.   PLoS One

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

(2012) O. B. Serebrennikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity

(2011) Makiko Kawaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Activating mutation in MET oncogene in familial colorectal cancer

(2011) Deborah W Neklason et al.   BMC CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

c-Met Is a Marker of Pancreatic Cancer Stem Cells and Therapeutic Target

(2011) Chenwei Li et al.   GASTROENTEROLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

(2011) R Szabo et al.   ONCOGENE

HGF-independent potentiation of EGFR action by c-Met

(2011) A M Dulak et al.   ONCOGENE

Activation of c-MET Induces a Stem-Like Phenotype in Human Prostate Cancer

(2011) Geert J. L. H. van Leenders et al.   PLoS One

c-MET as a potential therapeutic target and biomarker in cancer

(2011) J. Rafael Sierra et al.   Therapeutic Advances in Medical Oncology

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

(2010) Alexa B. Turke et al.   CANCER CELL

Acquired Resistance of Non-Small Cell Lung Cancer Cells to MET Kinase Inhibition Is Mediated by a Switch to Epidermal Growth Factor Receptor Dependency

(2010) U. McDermott et al.   CANCER RESEARCH

HGF Rescues Colorectal Cancer Cells from EGFR Inhibition via MET Activation

(2010) D. Liska et al.   CLINICAL CANCER RESEARCH

Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Adenocarcinoma

(2010) K. Kasahara et al.   CLINICAL CANCER RESEARCH

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Tumor Associated Macrophages Protect Colon Cancer Cells from TRAIL-Induced Apoptosis through IL-1β- Dependent Stabilization of Snail in Tumor Cells

(2010) Pawan Kaler et al.   PLoS One

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA

(2009) Kate A. Owen et al.   BIOCHEMICAL JOURNAL

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Lymphocytes in cancer development: Polarization towards pro-tumor immunity

(2009) Brian Ruffell et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients

(2009) Yuji Toiyama et al.   INTERNATIONAL JOURNAL OF CANCER

Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer

(2009) Jihong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Drug development of MET inhibitors: targeting oncogene addiction and expedience

(2008) Paolo M. Comoglio et al.   NATURE REVIEWS DRUG DISCOVERY

The biological role of HGF-MET axis in tumor growth and development of metastasis

(2007) Ewa Lesko   Frontiers in Bioscience-Landmark