Review
Pharmacology & Pharmacy
Hang Wang, Xianghuan Dong, Maher Un Nisa Awan, Jie Bai
Summary: This review briefly summarizes the studies on epigenetics involved in METH addiction, elucidating the molecular mechanism of METH addiction and the effects of METH on neurotransmitter release and brain area activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shuhan Bu, Krishna K. Singh
Summary: Autophagy plays a crucial role in cardiovascular diseases, with complex regulation involving epigenetic pathways. Understanding these pathways not only enhances the comprehension of CVDs, but may also offer new therapeutic targets and biomarkers for CVDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Elly I. Lewerissa, Nael Nadif Kasri, Katrin Linda
Summary: Autophagy is a crucial metabolic process for maintaining cellular homeostasis and survival. Recent studies have shown the importance of autophagy in brain function, particularly in neuronal development and functioning. Mutations in autophagy-related genes as well as genes involved in epigenetic regulation have been linked to neurodevelopmental disorders (NDDs). This suggests that aberrant autophagic regulation may contribute to nervous system impairments in NDDs with disturbed epigenetic regulation.
Article
Biochemistry & Molecular Biology
Saeid Ghavami, Mozhdeh Zamani, Mazaher Ahmadi, Mehran Erfani, Sanaz Dastghaib, Mahsa Darbandi, Sara Darbandi, Omid Vakili, Morvarid Siri, Beniamin Oskar Grabarek, Dariusz Boron, Maryam Zarghooni, Emilia Wiechec, Pooneh Mokarram
Summary: This article discusses the association between autophagy and epigenetics in gastrointestinal cancers (GICs), including their interplay, how epigenetic modifications affect cancer cell behavior, and how epigenetic drugs modulate autophagy to overcome chemoresistance in GICs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Consuelo Arias, Luis A. Salazar
Summary: Autophagy is a cellular mechanism that maintains cellular homeostasis. It declines in aging and is associated with osteoarthritis. MicroRNAs regulate autophagy, but only a few are involved in osteoarthritis. Epigenetic modifications could be a therapeutic opportunity for osteoarthritis. Polyphenols have the potential to reverse epigenetic alterations and modify autophagy in cartilage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Patrick J. Mulholland, Audrey E. Padula, Larry J. Wilhelm, Byung Park, Kathleen A. Grant, Betsy M. Ferguson, Rita Cervera-Juanes
Summary: This study reveals the important role of epigenetic regulation of the KCNN3 gene in alcohol-induced functional adaptations, by affecting surface trafficking and function of K(Ca)2 channels. The study found differential methylation in a specific region of KCNN3 in the nucleus accumbens tissue of alcohol-drinking monkeys and alcohol-dependent mice, which was associated with increased expression of alternative transcripts encoding apamin-insensitive and dominant-negative K(Ca)2 channel isoforms. Additionally, the study found significantly reduced expression of K(Ca)2.3 channels in the accumbens of heavy-drinking monkeys.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Maria Andres-Alonso, Michael R. Kreutz, Anna Karpova
Summary: The complex morphology and functional demands of neurons pose a challenge for proteostasis, particularly at presynaptic sites. Efficient mechanisms are required to ensure protein turnover between the cell body and synapses and to maintain synaptic function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Immunology
Kangling Zhang, Mark L. Sowers, Ellie I. Cherryhomes, Vipul K. Singh, Abhishek Mishra, Blanca I. Restrepo, Arshad Khan, Chinnaswamy Jagannath
Summary: Macrophages play a crucial role in controlling infections, particularly in tuberculosis caused by Mycobacterium tuberculosis (MTB). Glucose metabolism regulates macrophage-mediated antimicrobial mechanisms and also influences histone protein modifications, which control gene expression. Sirtuins are emerging as potential therapeutic targets for modifying immunometabolism to enhance macrophage function.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Yin Shi, Han-Ming Shen, Vidya Gopalakrishnan, Nancy Gordon
Summary: Autophagy is a highly conserved catabolic process that protects cells from harm and allows survival under stress conditions. The regulation of autophagy is complex, involving various signaling pathways including AMPK and mTOR. Understanding these regulatory mechanisms can lead to the discovery of new therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Chuan Liu, Ruidie Shi, Yuting Liu, Xiangwei Zhao, Xiujun Zhang, Haitao Wang, Lei Wu, Xueliang Shang
Summary: This study confirmed the effectiveness of low-frequency transcranial magnetic stimulation (LF-TMS) in protecting cognitive function, which can provide reference for future clinical treatment.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Glombik, Jan Detka, Bartosz Bobula, Joanna Bak, Magdalena Kusek, Krzysztof Tokarski, Boguslawa Budziszewska
Summary: This study analyzed the possible link between depression and hypothyroidism, finding that WKY rats showed weakened memory processes and reduced long-term potentiation, while PTU administration in Wistar rats decreased LTP and increased basal excitatory transmission. Differences in synaptic plasticity between strains were observed, suggesting a lower sensitivity of the hippocampus to thyroid hormones in depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M. Young
Summary: This study reveals the key regulatory role of Rac1 in synaptic transmission, mainly through modulating the dynamics of synaptic vesicle priming and potentially the release probability, affecting synaptic strength and short-term plasticity.
Article
Neurosciences
Yang Wang, Jingran Lin, Jiarui Li, Lu Yan, Wenwen Li, Xingzhi He, Huan Ma
Summary: Activity-dependent changes in protein expression are crucial for neuronal plasticity. Homeostatic synaptic up-scaling, induced primarily by neuronal inactivity, involves autophagy and the regulation of key synaptic proteins. The turnover mechanism of synaptic proteins in this process remains unclear.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Yu Chen, Junren Chen, Ziwei Xing, Cheng Peng, Dan Li
Summary: Neuroinflammation, driven by inflammatory mediators and characterized by microglial polarization, plays a crucial role in neurodegenerative diseases. Autophagy is closely associated with neuroinflammatory processes and can be regulated through mTOR inhibition, AMPK and FOXO1 activation. Epigenetic modifications, such as non-coding RNAs and histone acetylation, also influence autophagy and inflammation in neurological disorders.
Review
Biochemistry & Molecular Biology
Sabyasachi Maity, Raman Abbaspour, David Nahabedian, Steven A. Connor
Summary: The noradrenergic system plays a crucial role in memory formation and synaptic plasticity. Norepinephrine stimulates beta-ARs to regulate memory formation and affects neural circuit function through epigenetic modifications. Understanding these mechanisms is essential for studying brain disorders and developing neurotherapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Min Soo Kim, Jingqi Yan, Wenhe Wu, Guo Zhang, Yalin Zhang, Dongsheng Cai
Article
Multidisciplinary Sciences
Yumin Zhang, Gang Liu, Jingqi Yan, Yalin Zhang, Bo Li, Dongsheng Cai
NATURE COMMUNICATIONS
(2015)
Article
Neurosciences
Ziyan Zhang, Jingqi Yan, Honglian Shi
NEUROBIOLOGY OF DISEASE
(2016)
Article
Multidisciplinary Sciences
Yalin Zhang, Min Soo Kim, Baosen Jia, Jingqi Yan, Juan Pablo Zuniga-Hertz, Cheng Han, Dongsheng Cai
Article
Biochemistry & Molecular Biology
Jingqi Yan, Ziyan Zhang, Honglian Shi
CELLULAR AND MOLECULAR LIFE SCIENCES
(2012)
Article
Biochemistry & Molecular Biology
Jingqi Yan, Yan Zhao, Siqingaowa Suo, Yang Liu, Baolu Zhao
FREE RADICAL BIOLOGY AND MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Ziyan Zhang, Jingqi Yan, Saeid Taheri, Ke Jian Liu, Honglian Shi
FREE RADICAL BIOLOGY AND MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Jingqi Yan, Hai Zhang, Ye Yin, Juxue Li, Yizhe Tang, Sudarshana Purkayastha, Lianxi Li, Dongsheng Cai
Article
Multidisciplinary Sciences
Jingqi Yan, Bo Zhou, Saeid Taheri, Honglian Shi
Article
Multidisciplinary Sciences
Jingqi Yan, Morgan W. Porch, Brenda Court-Vazquez, Michael V. L. Bennett, R. Suzanne Zukin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biology
Di XiaoJing, Yan JingQi, Zhao Yan, Chang YanZhong, Zhao BaoLu
SCIENCE CHINA-LIFE SCIENCES
(2012)
Article
Biology
Yan JingQi, Zhao Yan, Zhao BaoLu
SCIENCE CHINA-LIFE SCIENCES
(2013)
Article
Endocrinology & Metabolism
Juxue Li, Yizhe Tang, Sudarshana Purkayastha, Jingqi Yan, Dongsheng Cai
MOLECULAR METABOLISM
(2014)
Article
Cell Biology
Ziyan Zhang, Jingqi Yan, Aaron B. Bowman, Miles R. Bryan, Rajat Singh, Michael Aschner