Spatial control of AMPK signaling at subcellular compartments

Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics

(2019) Zhen Chen et al.   Nature Communications

AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression

(2019) Haixin Zhao et al.   NATURE CELL BIOLOGY

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

(2019) Yue Zong et al.   CELL RESEARCH

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

(2019) Mengqi Li et al.   Cell Metabolism

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress

(2019) Qidong Li et al.   Cell Metabolism

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

(2019) Benjamin D. Stein et al.   Cell Reports

AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis

(2018) Ji-qiang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression

(2018) Tae Woo Jung et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

(2018) Lixin Wan et al.   MOLECULAR CELL

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

(2018) Lingtao Jin et al.   MOLECULAR CELL

Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction

(2018) Giuseppina Amodio et al.   Oxidative Medicine and Cellular Longevity

CaMKK2 Regulates Mechanosensitive Assembly of Contractile Actin Stress Fibers

(2018) Sari Tojkander et al.   Cell Reports

Structural basis of mitochondrial receptor binding and constriction by DRP1

(2018) Raghav Kalia et al.   NATURE

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

(2018) Di Wu et al.   NATURE

AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules

(2018) Tomoki Yano et al.   Scientific Reports

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

(2018) Lillian J. Eichner et al.   Cell Metabolism

STIM2 interacts with AMPK and regulates calcium-induced AMPK activation

(2018) Anoop Singh Chauhan et al.   FASEB JOURNAL

Role of the α2 subunit of AMP-activated protein kinase and its nuclear localization in mitochondria and energy metabolism-related gene expressions in C2C12 cells

(2018) Shiki Okamoto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Lysosomal storage diseases

(2018) Frances M. Platt et al.   Nature Reviews Disease Primers

A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi

(2017) Francesca Bottanelli et al.   MOLECULAR BIOLOGY OF THE CELL

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca 2+ /CaMKK2 Signaling to Enhance Tumor Cell Survival

(2017) Diana Vara-Ciruelos et al.   MOLECULAR CANCER RESEARCH

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

(2017) Jun-ichi Sakamaki et al.   MOLECULAR CELL

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

Mitochondrial fission and fusion

(2016) H. Lee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functional characterization of AMP-activated protein kinase signaling in tumorigenesis

(2016) Ji Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

(2016) Nathan P. Young et al.   GENES & DEVELOPMENT

Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation

(2016) Ananthalakshmy Sundararaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress

(2016) Xiaowen Liu et al.   NATURE CELL BIOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Differential regulation by AMP and ADP of AMPK complexes containing different   subunit isoforms

(2015) F. A. Ross et al.   BIOCHEMICAL JOURNAL

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

(2015) Serge Ducommun et al.   CELLULAR SIGNALLING

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Deconvoluting AMPK dynamics

(2015) Takafumi Miyamoto et al.   Oncotarget

Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators

(2015) Takafumi Miyamoto et al.   Cell Reports

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Structural basis of AMPK regulation by adenine nucleotides and glycogen

(2014) Xiaodan Li et al.   CELL RESEARCH

The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK

(2014) Tomoki Yano et al.   JOURNAL OF CELL BIOLOGY

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

(2013) Ya-Lin Zhang et al.   Cell Metabolism

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

Phenformin Activates the Unfolded Protein Response in an AMP-activated Protein Kinase (AMPK)-dependent Manner

(2013) Liu Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK phosphorylates GBF1 for mitotic Golgi disassembly

(2013) L. Mao et al.   JOURNAL OF CELL SCIENCE

AMPK Regulates ER Morphology and Function in Stressed Pancreatic β-Cells via Phosphorylation of DRP1

(2013) Jakob D. Wikstrom et al.   MOLECULAR ENDOCRINOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Protein Secretion and the Endoplasmic Reticulum

(2012) A. M. Benham   Cold Spring Harbor Perspectives in Biology

Regulation of AMPK by the Ubiquitin Proteasome System

(2011) Makhosazane Zungu et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

(2011) Lale Ozcan et al.   Annual Review of Medicine

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

The role of lysosomes in iron metabolism and recycling

(2011) Tino Kurz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

AMP-activated Protein Kinase (AMPK) Activation and Glycogen Synthase Kinase-3β (GSK-3β) Inhibition Induce Ca2+-independent Deposition of Tight Junction Components at the Plasma Membrane

(2011) Li Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

(2010) Y. Dong et al.   DIABETES

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

(2009) Brooke M. Emerling et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

Regulation of LKB1/STRAD Localization and Function by E-Cadherin

(2008) Michael Sebbagh et al.   CURRENT BIOLOGY

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

(2008) Jingzong Qi et al.   EMBO JOURNAL

STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7

(2008) Julia Dorfman et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL