Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

(2015) Juliane Zemdegs et al.   BRITISH JOURNAL OF PHARMACOLOGY

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

(2015) L. Palamiuc et al.   EMBO Molecular Medicine

Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: a prospective observational study

(2015) Johannes Dorst et al.   JOURNAL OF NEUROLOGY

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Eating behavior in frontotemporal dementia

(2015) Rebekah M. Ahmed et al.   NEUROLOGY

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

(2015) E. T. Cirulli et al.   SCIENCE

Defining the genetic connection linking amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD)

(2015) Serena Lattante et al.   TRENDS IN GENETICS

Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling

(2015) Jvalini T. Dwarkasing et al.   Journal of Cachexia Sarcopenia and Muscle

Effect of Presymptomatic Body Mass Index and Consumption of Fat and Alcohol on Amyotrophic Lateral Sclerosis

(2015) Mark H. B. Huisman et al.   JAMA Neurology

Dissection of genetic factors associated with amyotrophic lateral sclerosis

(2014) Claire S. Leblond et al.   EXPERIMENTAL NEUROLOGY

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

(2014) Maria A. Lim et al.   HUMAN MOLECULAR GENETICS

PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding

(2014) Lihong Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial

(2014) Anne-Marie Wills et al.   LANCET

Neurobiology of food intake in health and disease

(2014) Gregory J. Morton et al.   NATURE REVIEWS NEUROSCIENCE

Systemic metabolism in frontotemporal dementia

(2014) R. M. Ahmed et al.   NEUROLOGY

Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways

(2014) Jiamei Lian et al.   PSYCHONEUROENDOCRINOLOGY

Quantifying the Eating Abnormalities in Frontotemporal Dementia

(2014) Rebekah M. Ahmed et al.   JAMA Neurology

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons

(2013) Jong-Woo Sohn et al.   CELL

Lifetime physical activity and the risk of amyotrophic lateral sclerosis

(2013) M. H. B. Huisman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: The EPIC cohort

(2013) V. Gallo et al.   NEUROLOGY

Adipose Tissue Distribution Predicts Survival in Amyotrophic Lateral Sclerosis

(2013) Eva Lindauer et al.   PLoS One

Degeneration of serotonergic neurons in amyotrophic lateral sclerosis: a link to spasticity

(2012) Christel Dentel et al.   BRAIN

Alterations to Melanocortinergic, GABAergic and Cannabinoid Neurotransmission Associated with Olanzapine-Induced Weight Gain

(2012) Katrina Weston-Green et al.   PLoS One

A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis

(2012) Luc Dupuis et al.   PLoS One

Convergent Evidence from Mouse and Human Studies Suggests the Involvement of Zinc Finger Protein 326 Gene in Antidepressant Treatment Response

(2012) Ying-Jay Liou et al.   PLoS One

Premorbid body mass index and risk of amyotrophic lateral sclerosis

(2012) Éilis J. O'Reilly et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study: Table 1

(2011) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Central melanocortin receptor agonist reduces hepatic lipogenic gene expression in streptozotocin-induced diabetic mice

(2011) Arnold Leckstrom et al.   LIFE SCIENCES

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

(2011) Sabrina Paganoni et al.   MUSCLE & NERVE

Brain PPAR-γ promotes obesity and is required for the insulin–sensitizing effect of thiazolidinediones

(2011) Min Lu et al.   NATURE MEDICINE

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance

(2011) Ralph A. DeFronzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired glucose tolerance in patients with amyotrophic lateral sclerosis

(2010) Pierre-Francois Pradat et al.   Amyotrophic Lateral Sclerosis

Eating and hypothalamus changes in behavioral-variant frontotemporal dementia

(2010) Olivier Piguet et al.   ANNALS OF NEUROLOGY

Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis

(2010) J. Dorst et al.   JOURNAL OF NEUROLOGY

Alteration of nutritional status at diagnosis is a prognostic factor for survival of amyotrophic lateral sclerosis patients

(2010) B. Marin et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Melanocortin signaling in the CNS directly regulates circulating cholesterol

(2010) Diego Perez-Tilve et al.   NATURE NEUROSCIENCE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypermetabolism in ALS patients: an early and persistent phenomenon

(2009) C. Bouteloup et al.   JOURNAL OF NEUROLOGY

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors

(2009) Shona L. Kirk et al.   PSYCHOPHARMACOLOGY

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

(2008) L. Dupuis et al.   NEUROLOGY

5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis

(2008) Yong Xu et al.   NEURON

Serotonin 5-HT2CReceptor Agonist Promotes Hypophagia via Downstream Activation of Melanocortin 4 Receptors

(2007) Daniel D. Lam et al.   ENDOCRINOLOGY