Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer’s disease model mice

A role for cyclooxygenase-1 in β-amyloid-induced neuroinflammation

(2016) Eduardo Candelario-Jalil   Aging-US

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease

(2015) Leticia M. Toledo-Sherman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

(2014) Jenny U. Johansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling

(2014) N. S. Woodling et al.   JOURNAL OF NEUROSCIENCE

Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia

(2013) J. U. Johansson et al.   JOURNAL OF NEUROSCIENCE

Differential stem- and progenitor-cell trafficking by prostaglandin E2

(2013) Jonathan Hoggatt et al.   NATURE

Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care

(2013) Ludwig Trillo et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

(2013) Wei Wu et al.   PLoS One

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Inflammatory prostaglandin E2signaling in a mouse model of Alzheimer disease

(2012) Ju Shi et al.   ANNALS OF NEUROLOGY

FoxO6 regulates memory consolidation and synaptic function

(2012) D. A. M. Salih et al.   GENES & DEVELOPMENT

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission

(2012) Wei Xu et al.   NEURON

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

(2012) L. Pilotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

(2012) A. T. van der Goot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators

(2011) Eduard Dolušić et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synaptic and Extrasynaptic NMDA Receptors Differentially Modulate Neuronal Cyclooxygenase-2 Function, Lipid Peroxidation, and Neuroprotection

(2011) D. T. Stark et al.   JOURNAL OF NEUROSCIENCE

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer's disease

(2011) Sergey Kalinin et al.   NEUROBIOLOGY OF AGING

Pumilio-2 Function in the Mouse Nervous System

(2011) Henrike Siemen et al.   PLoS One

Kynurenine and its metabolites in Alzheimer's disease patients

(2010) E Gulaj et al.   Advances in Medical Sciences

Suppressed Accumulation of Cerebral Amyloid β Peptides in Aged Transgenic Alzheimer’s Disease Mice by Transplantation with Wild-Type or Prostaglandin E2 Receptor Subtype 2-Null Bone Marrow

(2010) C. Dirk Keene et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease

(2010) Brandy L. Wilkinson et al.   NEUROBIOLOGY OF AGING

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Neurodegenerative Diseases Target Large-Scale Human Brain Networks

(2009) William W. Seeley et al.   NEURON

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

(2008) Linda A. Kotilinek et al.   BRAIN

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

(2008) R. Minkeviciene et al.   JOURNAL OF NEUROCHEMISTRY

Enkephalin Elevations Contribute to Neuronal and Behavioral Impairments in a Transgenic Mouse Model of Alzheimer's Disease

(2008) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

COX-2 oxidative metabolism of endocannabinoids augments hippocampal synaptic plasticity

(2008) Hongwei Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY