A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

(2018) Satyaprakash Nayak et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts

(2018) Mary Courtney Moore et al.   DIABETES

Clinical Evaluation of MK-2640: An Insulin Analog with Glucose-Responsive Properties

(2018) Alexander W. Krug et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Model-Based Meta-Analysis of 24 Antihyperglycemic Drugs for Type 2 Diabetes: Comparison of Treatment Effects at Therapeutic Doses

(2018) Alan Maloney et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Glucose uptake saturation explains glucose kinetics profiles measured by different tests

(2016) Roberto Bizzotto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Euglycaemic glucose clamp: what it can and cannot do, and how to do it

(2016) Tim Heise et al.   DIABETES OBESITY & METABOLISM

Impact of the mode of protraction of basal insulin therapies on their pharmacokinetic and pharmacodynamic properties and resulting clinical outcomes

(2016) Tim Heise et al.   DIABETES OBESITY & METABOLISM

Pursuit of a perfect insulin

(2016) Alexander N. Zaykov et al.   NATURE REVIEWS DRUG DISCOVERY

Early Clinical Detection of Pharmacologic Response in Insulin Action in a Nondiabetic Insulin-Resistant Population

(2015) Sudha S. Shankar et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Insulin resistance in patients with type 1 diabetes assessed by glucose clamp studies: systematic review and meta-analysis

(2015) E. Donga et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Smart approaches to glucose-responsive drug delivery

(2015) Matthew J. Webber et al.   JOURNAL OF DRUG TARGETING

Insulin resistance in type 1 diabetes mellitus

(2015) Kirti Kaul et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

(2015) Jicheng Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

(2015) Danny Hung-Chieh Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New forms of insulin and insulin therapies for the treatment of type 2 diabetes

(2015) Avivit Cahn et al.   Lancet Diabetes & Endocrinology

The University of Virginia/Padova Type 1 Diabetes Simulator Matches the Glucose Traces of a Clinical Trial

(2014) Roberto Visentin et al.   Diabetes Technology & Therapeutics

Managing diabetes with nanomedicine: challenges and opportunities

(2014) Omid Veiseh et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoglycaemia in diabetes mellitus: epidemiology and clinical implications

(2014) Brian M. Frier   Nature Reviews Endocrinology

Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society

(2013) E. R. Seaquist et al.   DIABETES CARE

Basal insulin analogues in the management of diabetes mellitus: what progress have we made?

(2013) David R. Owens et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Severe Hypoglycemia Predicts Mortality in Diabetes

(2012) P. E. Cryer   DIABETES CARE

Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps

(2012) C. S. Tam et al.   DIABETES CARE

The pharmacokinetics and pharmacodynamics of rapid-acting insulin analogues and their clinical consequences

(2012) P. D. Home   DIABETES OBESITY & METABOLISM

Organization of Glucose-Responsive Systems and Their Properties

(2011) Qian Wu et al.   CHEMICAL REVIEWS

Insulin Glulisine Compared to Insulin Aspart and to Insulin Lispro Administered by Continuous Subcutaneous Insulin Infusion in Patients with Type 1 Diabetes: A Randomized Controlled Trial

(2011) Arianne C. van Bon et al.   Diabetes Technology & Therapeutics