Article
Biotechnology & Applied Microbiology
Markus Laubach, Buddhi Herath, Nathalie Bock, Sinduja Suresh, Siamak Saifzadeh, Bronwin L. Dargaville, Jacqui McGovern, Marie-Luise Wille, Dietmar W. Hutmacher, Flavia Medeiros Savi
Summary: This study explores the use of Voronoi tessellation design in 3D-printed mPCL-HA composite scaffolds for scaffold-guided bone regeneration (SGBR). The results suggest that the Voronoi design allows for slow degradation and high osteogenicity, promoting tissue regeneration and bone formation without adverse reactions. The mPCL-HA Voronoi scaffolds have the potential for further preclinical animal studies before clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Xiongcheng Xu, Long Xiao, Yanmei Xu, Jin Zhuo, Xue Yang, Li Li, Nianqi Xiao, Jing Tao, Quan Zhong, Yanfen Li, Yuling Chen, Zhibin Du, Kai Luo
Summary: The study developed a PCL/LAP scaffold with excellent bioactivity using 3D printing technology, promoting osteogenic differentiation and angiogenesis of bone marrow mesenchymal stem cells, resulting in significant enhancement of vascularized bone formation in a calvarial defect model.
REGENERATIVE BIOMATERIALS
(2021)
Article
Chemistry, Physical
Hee-Yeon Kim, Byung-Hoon Kim, Myung-Sun Kim
Summary: This study investigates the surface characterization and pre-osteoblast biological behaviors of a 3D poly(ε-caprolactone)/beta-tricalcium phosphate scaffold modified by amine plasma-polymerization. The results demonstrate that the scaffold treated with DACH plasma-polymerization exhibits the highest bioactivity, making it a promising candidate for pre-osteoblast osteoblast differentiation.
Article
Engineering, Biomedical
Justin J. Chung, Jin Yoo, Brian S. T. Sum, Siwei Li, Soojin Lee, Tae Hee Kim, Zhenlun Li, Molly M. Stevens, Theoni K. Georgiou, Youngmee Jung, Julian R. Jones
Summary: Inorganic-organic hybrid biomaterials made with star polymer and silica are successfully 3D printed as bone substitutes, showing promising mechanical properties. The hybrid scaffolds are able to promote osteoblast cell adhesion in vitro and demonstrate osteogenic and angiogenic properties in a rat model.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chen Yang, Zhiwei Zheng, Muhammad Rizwan Younis, Chenle Dong, Yahong Chen, Shan Lei, Dong-Yang Zhang, Jiayingzi Wu, Xueqing Wu, Jing Lin, Xiansong Wang, Peng Huang
Summary: A multifunctional scaffold for diabetic bone defect has been developed, with properties including osteogenesis, angiogenesis, and anti-inflammation. Enzyme functionalization and mineralization were key strategies in addressing the high risk of fractures and poor bone healing ability in diabetic patients. The scaffold showed promising outcomes in enhancing bone tissue regeneration in in vitro and in vivo studies, highlighting the potential of multifunctional scaffolds for diabetic bone regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Lei Tong, Xiaocong Pu, Quanying Liu, Xing Li, Manyu Chen, Peilei Wang, Yaping Zou, Gonggong Lu, Jie Liang, Yujiang Fan, Xingdong Zhang, Yong Sun
Summary: In this study, a chemically integrated 3D-printed bone scaffold with enhanced mechanical structure and biofunctional hydrogel was fabricated. It successfully initiated early osteogenesis and angiogenesis in vivo and achieved substantial bone reconstruction. This approach provides a new perspective for the structural design of regenerative 3D-printed bone scaffolds.
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Izabella Rajzer, Anna Kurowska, Jana Frankova, Renata Sklenarova, Anna Nikodem, Michal Dziadek, Adam Jablonski, Jaroslaw Janusz, Piotr Szczygiel, Magdalena Ziabka
Summary: In this study, composite filaments modified with bioglass and Zn-doped bioglass were developed for the production of osteochondral implants. The manufactured filaments exhibited bioactivity, strength, and flexibility. These filaments were then used to produce scaffolds, and the effect of bioglass addition on the mechanical and biological properties of the samples was investigated. The presence of a spatial microstructure within the scaffolds reduced their mechanical properties. In vitro mineralization experiments showed apatite formation on scaffolds modified with bioglass, while apatite formation was delayed on scaffolds modified with Zn-doped bioglass. Innovative 3D-printing filaments containing bioglasses were successfully applied to print bioactive scaffolds suitable for cell attachment and proliferation.
Article
Chemistry, Multidisciplinary
Chao He, Caihong Dong, Hui Hu, Luodan Yu, Yu Chen, Yongqiang Hao
Summary: A multifunctional and exquisite photosynthetic oxygen-self-generated therapeutic platform has been engineered for enhanced photodynamic therapy against OS. The study provides insight into the bacteria-enhanced PDT against OS and the following augmented osseous tissue regeneration.
Article
Orthopedics
Wen-Xiang Cheng, Yan-Zhi Liu, Xiang-Bo Meng, Zheng-Tan Zheng, Ling-Li Li, Li-Qing Ke, Ling Li, Cui-Shan Huang, Guo-Yuan Zhu, Hu-Dan Pan, Ling Qin, Xin-Luan Wang, Peng Zhang
Summary: The study demonstrates that CuB can enhance angiogenesis in vitro and promote neovascularization and bone regeneration in a rat model. CuB-incorporated scaffold showed improved mechanical properties and successfully stimulated angiogenic signaling pathways, highlighting its potential as a therapeutic agent in tissue engineering for bone repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Materials Science, Multidisciplinary
Boqing Zhang, Wenzhao Wang, Xingyu Gui, Ping Song, Haoyuan Lei, Zhengyong Li, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: The rapid development of regenerative medicine has provided new opportunities for disease treatment, but faces technical and translational barriers in clinically adopted approaches. The selection and screening efficiency of key material factors are relatively low, and the design and screening of biomaterials genomics are crucial for achieving osteoinduction and osteoconduction. The bone regeneration test chip fabricated by digital light projection enables high-throughput screening of specific biological functions in regenerative medicine.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Biomedical
Bankole I. Oladapo, S. Abolfazl Zahedi, Sikiru O. Ismail, Francis T. Omigbodun, Oluwole K. Bowoto, Mattew A. Olawumi, Musa A. Muhammad
Summary: The study aimed to enhance the adhesion between implants and surrounding tissues by incorporating PEEK with cHAp to fabricate PEEK-cHAp biocomposite, using a surface treatment strategy to create microporous architectures and investigate its mechanical and thermal strengths as well as in vitro cytotoxicity. Innovative technique was used to create porous nanostructure to promote biological integration.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Engineering, Multidisciplinary
Lin Zou, Le Hu, Panpan Pan, Solaiman Tarafder, Mingzu Du, Yusheng Geng, Gan Xu, Li Chen, Jingdi Chen, Chang H. Lee
Summary: The polycaprolactone and nano-hydroxyapatite composite is a promising material for bone scaffolds with excellent mechanical properties. In this study, a 3D printed scaffold embedded with poly (lactic-co-glycolic acid) microspheres was developed for controlled delivery of Icariin to promote bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Dentistry, Oral Surgery & Medicine
P-C Chang, Z-J Lin, H-T Luo, C-C Tu, W-C Tai, C-H Chang, Y-C Chang
Summary: Recent research has focused on developing scaffolds with intricate configurations and manipulating extracellular matrix stiffness towards osteogenesis for maxillofacial defect regeneration. The study proposed infusing a degradable RGD-functionalized alginate matrix (RAM) with osteoid-like stiffness into a rigid 3D-printed hydroxyapatite scaffold. In vitro and in vivo results showed that RAM with osteoid-like stiffness, particularly when oxidized, significantly enhanced bone marrow stem cell viability, migration, and osteogenic differentiation, ultimately promoting robust bone formation in maxillofacial regeneration.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lingfei Xiao, Minhao Wu, Feifei Yan, Yuanlong Xie, Zhibo Liu, Huayi Huang, Zhiqiang Yang, Shiyi Yao, Lin Cai
Summary: The treatment and repair of large bone defects is a major challenge in clinical settings. 3D-mineralized polycaprolactone nanofiber scaffolds with radially interconnected macrochannels and aligned nanofibers have shown significant potential in guiding cell arrangement and promoting tissue regeneration, especially for bone tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Abdalla Abdal-Ha, Stephen Hamlet, Saso Ivanovski
Article
Dentistry, Oral Surgery & Medicine
Jennifer Kraatz, Ha Hoang, Saso Ivanovski, Robert S. Ware, Leonard A. Crocombe
JOURNAL OF PERIODONTOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kelly McGowan, Caroline Acton, Saso Ivanovski, Newell W. Johnson, Robert S. Ware
Review
Polymer Science
Michal Bartnikowski, Tim R. Dargaville, Saso Ivanovski, Dietmar W. Hutmacher
PROGRESS IN POLYMER SCIENCE
(2019)
Article
Oncology
Naif Alqurashi, Saeed M. Hashimi, Faisal Alowaidi, Saso Ivanovski, Amro Farag, Ming Q. Wei
Article
Dentistry, Oral Surgery & Medicine
Stephen M. Hamlet, Ryan S. B. Lee, Ho-Jin Moon, Mohammed A. Alfarsi, Saso Ivanovski
CLINICAL ORAL IMPLANTS RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Biochemical Research Methods
F. Blaudez, S. Ivanovski, S. Hamlet, C. Vaquette
Article
Chemistry, Physical
Abdalla Abdal-hay, Karan Gulati, Tulio Fernandez-Medina, Ma Qian, Saso Ivanovski
APPLIED SURFACE SCIENCE
(2020)
Article
Dentistry, Oral Surgery & Medicine
Michael Payer, Wah Ching Tan, Jie Han, Saso Ivanovski, Nikos Mattheos, Bjarni E. Pjetursson, Longfei Zhuang, George Fokas, May C. M. Wong, Stephan Acham, Niklaus P. Lang
CLINICAL ORAL IMPLANTS RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Faustino Mercado, Stephen Hamlet, Saso Ivanovski
JOURNAL OF PERIODONTAL RESEARCH
(2020)
Article
Engineering, Biomedical
Marcin Gwiazda, Sudheesh Kumar, Wojciech Swieszkowski, Saso Ivanovski, Cedryck Vaquette
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Review
Materials Science, Biomaterials
Hasham S. Sofi, Abdalla Abdal-hay, Saso Ivanovski, Yu Shrike Zhang, Faheem A. Sheikh
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)