Journal
NANO TODAY
Volume 41, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2021.101297
Keywords
osteosarcoma; Cyanobacteria; 3D-printing; photodynamic therapy; bone regeneration
Categories
Funding
- Oebiotech Co., Ltd.
- National Key R&D Program of China [2016YFC1100600, 2016YFA0203700]
- National Natural Science Foundation of China [51672303, 81972058]
- Excellent Young Scientist Foundation of NSFC [51722211]
- Program of Shanghai Subject Chief Scientist [18XD1404300]
- Shanghai Sailing Program [19YF1453700]
- Youth Program of National Natural Science Foundation of China [51902334]
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A multifunctional and exquisite photosynthetic oxygen-self-generated therapeutic platform has been engineered for enhanced photodynamic therapy against OS. The study provides insight into the bacteria-enhanced PDT against OS and the following augmented osseous tissue regeneration.
Osteosarcoma (OS) is the most frequent bone tumor which mainly threatens children and adolescents. The current mainstream therapeutic strategies for OS are surgical resection, chemotherapy and radiotherapy. However, the critical bone defects after the surgical resection, chemotherapy resistance and adverse effects are still formidable obstacles in the OS treatment. Herein, a multifunctional and exquisite photosynthetic oxygen-self-generated therapeutic platform has been engineered by integrating the photosensitive and photosynthetic Ce-6-contained cyanobacteria onto 3D-printing CaCO3-PCL scaffolds, which has achieved the enhanced photodynamic therapy (PDT) against OS by photosynthetic oxygenation-induced tumor-hypoxia alleviation and the subsequent prompted bone regeneration by local oxygenation. Especially, mRNA sequencing (RNA-seq) was employed to further decipher the underlying mechanisms, which indicated that cell proliferation was inhibited and cell death was induced responding to the reactive oxygen species (especially the singlet oxygen) related cytotoxicity. This study provides an insightful design and efficient paradigm for the bacteria-enhanced PDT against OS and the following augmented osseous tissue regeneration. (C) 2021 Published by Elsevier Ltd.
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