Article
Materials Science, Multidisciplinary
Boqing Zhang, Wenzhao Wang, Xingyu Gui, Ping Song, Haoyuan Lei, Zhengyong Li, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: The rapid development of regenerative medicine has provided new opportunities for disease treatment, but faces technical and translational barriers in clinically adopted approaches. The selection and screening efficiency of key material factors are relatively low, and the design and screening of biomaterials genomics are crucial for achieving osteoinduction and osteoconduction. The bone regeneration test chip fabricated by digital light projection enables high-throughput screening of specific biological functions in regenerative medicine.
APPLIED MATERIALS TODAY
(2022)
Article
Engineering, Multidisciplinary
Cuidi Li, Zhenjiang Ma, Wentao Li, Tianyang Jie, Liping Zhong, Hongfang Chen, Wenhao Wang, Jinwu Wang, Wenguo Cui, Yongxiang Zhao
Summary: The study combines self-assembled vaccines with 3D-printed scaffolds to activate local antigen-specific immune responses. The results show that this method effectively recruits and activates immune cells, promoting angiogenesis and bone regeneration.
Article
Materials Science, Multidisciplinary
Haibo Xiang, Xiaoqin Dai, Wenquan Xu, Siteng Li, Xiaodong Yang, Zhuobin Huang, Ruanbing Li, Cheng Yang, Hong Chang, Yuhui Chen, Chong Wang, Shicai Fan
Summary: In this study, incorporating bifunctional LAP into tissue engineering scaffolds showed improved angiogenesis and osteogenesis, providing an efficient way to treat critical-sized bone defects.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Chong Wang, Jiahui Lai, Kai Li, Shaokui Zhu, Bingheng Lu, Jia Liu, Yujin Tang, Yen Wei
Summary: 3D printing is increasingly used to create advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths for improved bone regeneration. Customized scaffolds were produced using cryogenic 3D printing of beta-tricalcium phosphate and osteogenic peptide inks, and coated with angiogenic peptide hydrogel to enhance vascularization. The scaffolds had a hierarchically porous structure similar to human cancellous bone and showed high viability for both endothelial cells and mesenchymal stem cells. Improved in vitro migration and angiogenesis were observed for scaffolds with angiogenic peptide, while enhanced osteogenic differentiation was seen in scaffolds containing osteogenic peptide. In vivo, scaffolds with both peptides showed increased angiogenesis and new bone formation.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Jin Qi, Yili Wang, Liping Chen, Linjie Chen, Feng Wen, Lijiang Huang, Pfukwa Rueben, Chunwu Zhang, Huaqiong Li
Summary: Large size bone defects are a global health problem, and 3D printing technology is being used to prepare multifunctional scaffolds for bone reconditioning and regeneration. A study has demonstrated that a 3D-printed scaffold made with polydopamine (PDA) decoration and the sustained release of bioactive ions improved surface bioactivity and promoted better osteogenesis and angiogenesis. This finding could provide a valuable basis for custom implants in extensive bone defect repair applications.
REGENERATIVE BIOMATERIALS
(2023)
Review
Engineering, Biomedical
Weiying Lu, Yang Shi, Zhijian Xie
Summary: Three-dimensional (3D) printing technology has the potential to address the challenges of large bone defect regeneration by facilitating satisfactory revascularization. This review summarizes different designs related to angiogenesis in 3D-printed scaffolds, and proposes structural design suggestions to achieve rapid blood vessel formation.
BIO-DESIGN AND MANUFACTURING
(2023)
Review
Engineering, Biomedical
Hongjian Zhang, Chengtie Wu
Summary: Neurovascular networks play important roles in tissue and organ regeneration. Traditional scaffolds cannot meet the requirement of angiogenesis and innervation, but 3D printing provides a versatile technique to fabricate biomimetic scaffolds. This review summarizes the progress in using 3D-printed biomaterials for vascularized and innervated tissue regeneration.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Materials Science, Multidisciplinary
Bo Chen, Zhengjie Lin, Qimanguli Saiding, Yongcan Huang, Yi Sun, Xinyun Zhai, Ziyu Ning, Hai Liang, Wei Qiao, Bingsheng Yu, W. K. Kelvin Yeung, Jie Shen
Summary: The use of three-dimensional (3D) printed biocomposite scaffolds, reinforced with magnesium oxide (MgO), has shown promising results in the treatment of critical-sized bone defects (CSD). The incorporation of magnesium ions (Mg2+) in the scaffold enhances mechanical performance and cytocompatibility, leading to improved bone regeneration and repair.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Ruggero Belluomo, Azin Khodaei, Saber Amin Yavari
Summary: Bone tissue is a favorable environment for metastatic cancer cells to grow and develop tumors. Bioceramics have gained attention in bone tissue engineering and drug delivery applications. Additive manufacturing of bioceramics allows for filling irregular voids and creating patient-specific implants. This article explores the recent advances in additively manufactured bioceramics and ceramic-based composites used in the treatment and reconstruction of bone tumors.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Ainhoa Gonzalez-Pujana, Teresa Carranza, Edorta Santos-Vizcaino, Manoli Igartua, Pedro Guerrero, Rosa Maria Hernandez, Koro de la Caba
Summary: In this study, dual 3D printed and electrospun polycaprolactone (PCL) scaffolds with multiple mesh layers were successfully prepared. The scaffolds demonstrated enhanced hydrophilicity, cell adhesion and growth. Biological results indicated that the hybrid PCL scaffolds are biocompatible and capable of guiding osteogenic differentiation.
Article
Biochemistry & Molecular Biology
Tatiana I. Vinogradova, Mikhail S. Serdobintsev, Evgenia G. Korzhikova-Vlakh, Viktor A. Korzhikov-Vlakh, Alexander S. Kaftyrev, Natalya M. Blum, Natalya Yu. Semenova, Dilyara S. Esmedlyaeva, Marina E. Dyakova, Yulia A. Nashchekina, Marine Z. Dogonadze, Natalia V. Zabolotnykh, Petr K. Yablonsky
Summary: This study compared the effects of autografting and implantation with a biodegradable composite scaffold for bone-defect regeneration in a tuberculosis rabbit model. The results showed that the porous three-dimensional composite materials prepared by 3D printing could promote bone regeneration and healing. This has important implications for the treatment of tuberculosis patients.
Article
Engineering, Biomedical
Justin J. Chung, Jin Yoo, Brian S. T. Sum, Siwei Li, Soojin Lee, Tae Hee Kim, Zhenlun Li, Molly M. Stevens, Theoni K. Georgiou, Youngmee Jung, Julian R. Jones
Summary: Inorganic-organic hybrid biomaterials made with star polymer and silica are successfully 3D printed as bone substitutes, showing promising mechanical properties. The hybrid scaffolds are able to promote osteoblast cell adhesion in vitro and demonstrate osteogenic and angiogenic properties in a rat model.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Xiongcheng Xu, Long Xiao, Yanmei Xu, Jin Zhuo, Xue Yang, Li Li, Nianqi Xiao, Jing Tao, Quan Zhong, Yanfen Li, Yuling Chen, Zhibin Du, Kai Luo
Summary: The study developed a PCL/LAP scaffold with excellent bioactivity using 3D printing technology, promoting osteogenic differentiation and angiogenesis of bone marrow mesenchymal stem cells, resulting in significant enhancement of vascularized bone formation in a calvarial defect model.
REGENERATIVE BIOMATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Lijia Cheng, Shoma K. Suresh, Hongyan He, Ritu Singh Rajput, Qiyang Feng, Saravanan Ramesh, Yuzhuang Wang, Sasirekha Krishnan, Serge Ostrovidov, Gulden Camci-Unal, Murugan Ramalingam
Summary: Recent advancements in 3D printing technology show great potential in fabricating scaffolds and implants for biomedical applications, particularly in bone repair and regeneration. The integration of different living cells in 3D constructs made from conventional biomaterials can create artificial bone grafts capable of regenerating damaged tissues. Various conventional and nanomaterials have been utilized in the production of 3D-printed scaffolds for bone tissue engineering applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Yuchen Tian, Hongshi Ma, Xiaopeng Yu, Boshi Feng, Zhibo Yang, Wei Zhang, Chengtie Wu
Summary: Repairing critical-size bone defects is a challenging task in clinical practice, and early-stage vascularization is crucial for bone regeneration. This study utilized 3D printing technology to create beta-tricalcium phosphate bioceramic scaffolds with a hollow tube structure, which demonstrated superior osteogenic and angiogenic properties compared to solid scaffolds. These scaffolds have great potential for the treatment of critical-size bone defects.
BIOMEDICAL MATERIALS
(2023)